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T83000Antitumor agent-89;化合物 Antitumor agent-89Antitumor agent-89
Antitumor agent-89 (Compd OTS-5), a naturally occurring compound, exhibits weak inhibitory activity against fMLP-induced superoxide generation [1].
价 格:¥电议型 号:T83000产 地:中国大陆
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T75078Antitumor agent-86;化合物 Antitumor agent-86Antitumor agent-86
Antitumor agent-86 (compound 5a) demonstrates efficacy against MCF-7 breast cancer cells, manifesting an inhibitory concentration (IC 50) of 2.62 ?M. It promotes apoptosis and cell cycle arrest, exhibiting antineoplastic effects through the disruption of RAS/PI3K/Akt/JNK signaling pathways [1].
价 格:¥电议型 号:T75078产 地:中国大陆
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T72572Antitumor agent-85;化合物 Antitumor agent-85Antitumor agent-85
Antitumor agent-85, a G-quadruplex (G4)-ligand, stabilizes various G4-DNA structures and possesses potent anti-tumor properties.
价 格:¥电议型 号:T72572产 地:中国大陆
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T72571Antitumor agent-84;化合物 Antitumor agent-84Antitumor agent-84
Antitumor Agent-84, a G-quadruplex (G4)-ligand, stabilizes various G4-DNA structures, demonstrating highly effective antitumor properties.
价 格:¥电议型 号:T72571产 地:中国大陆
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T72570Antitumor agent-83;化合物 Antitumor agent-83Antitumor agent-83
Antitumor agent-83 acts as a BAX pro-apoptotic protein activator, significantly inhibiting tumor cell proliferation and mediating cell apoptosis through BAX´s conformational activation. It also impedes the A549 cell cycle, demonstrating robust metabolic stability and an in vitro CYPs spectrum.
价 格:¥电议型 号:T72570产 地:中国大陆
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T72561Antitumor agent-82;化合物 Antitumor agent-82Antitumor agent-82
Antitumor Agent-82 is a potent anti-tumor compound that exhibits anti-proliferative activity and induces cell autophagy through the ATG5/ATG7 signaling pathway.
价 格:¥电议型 号:T72561产 地:中国大陆
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T72560Antitumor agent-81;化合物 Antitumor agent-81Antitumor agent-81
Antitumor agent-81, a P62-RNF168 agonist with low cytotoxicity, enhances the P62-RNF168 interaction, leading to decreased RNF168-mediated H2A ubiquitination and impaired homologous recombination-mediated DNA repair. Additionally, it exhibits dose-dependent inhibition of xenograft tumor growth in mice.
价 格:¥电议型 号:T72560产 地:中国大陆
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T72552Antitumor agent-88;化合物 Antitumor agent-88Antitumor agent-88
Antitumor agent-88, a competitive inhibitor of CYP1A1 (K i: 1.4 μM), demonstrates significant antimitotic activity by arresting cells in the G2/M phase and disrupting the microtubule network and cytoskeleton in CYP1A1-expressing breast cancer cells.
价 格:¥电议型 号:T72552产 地:中国大陆
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T72551Antitumor agent-87;化合物 Antitumor agent-87Antitumor agent-87
Antitumor agent-87 is a potent compound with antitumoral activity, demonstrating a high affinity for CYP1A1, evidenced by a K i value of 0.23 ?M. It exhibits antiproliferative effects and induces cell cycle arrest at the G2/M phase, thereby showing its effectiveness as an antitumor agent.
价 格:¥电议型 号:T72551产 地:中国大陆
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T72506Antioxidant agent-8;化合物 Antioxidant agent-8Antioxidant agent-8
Antioxidant agent-8 is an orally active compound that inhibits the deposition of Aβ 1-42 by preventing fibril aggregation (IC 50 =11.15 ?M) and aiding in fibril disaggregation (IC 50 =6.87 ?M). Moreover, it effectively counters Cu2+-induced Aβ 1-42 fibril aggregation and disaggregation, exhibiting lower IC 50 values of 3.69 ?M and 3.35 ?M, respectively. This compound also possesses antioxidant and anti-inflammatory activities, demonstrates biosafety and blood-brain barrier permeability, and offe
价 格:¥电议型 号:T72506产 地:中国大陆
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T72414Antimicrobial agent-8;化合物 Antimicrobial agent-8Antimicrobial agent-8
Antimicrobial Agent-8 exhibits a high level of antimicrobial efficacy, demonstrating a minimum inhibitory concentration (MIC) range of 2-8 μg/mL against both Gram-negative and Gram-positive bacteria. Furthermore, this compound also possesses anti-inflammatory properties, effectively combating lipopolysaccharide-induced inflammation.
价 格:¥电议型 号:T72414产 地:中国大陆
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T72263Antituberculosis agent-8;化合物 Antituberculosis agent-8Antituberculosis agent-8
Antituberculosis agent-8 is an antitubercular compound effective against M. tuberculosis H37Rv, demonstrating a minimum inhibitory concentration (MIC) of 3.53 μM (1.6 μg/mL). Additionally, it exhibits potent antifungal properties against A. niger, with an MIC of 62.50 μM.
价 格:¥电议型 号:T72263产 地:中国大陆
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T62012Antiproliferative agent-8;化合物 Antiproliferative agent-8Antiproliferative agent-8
Antiproliferative agent-8 (Compound 5a) is an anti-cancer compoundwith antiproliferative activity. Antiproliferative agent-8 can significantly increase the P53 levels.
价 格:¥电议型 号:T62012产 地:中国大陆
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T61221Antiparasitic agent-8;化合物 Antiparasitic agent-8Antiparasitic agent-8
Antiparasitic agent-8 (Compound 9) exhibits potent antiparasitic activity against Hymenolepis nana, while demonstrating low levels of cytotoxicity [1].
价 格:¥电议型 号:T61221产 地:中国大陆
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T60638Antileishmanial agent-8;化合物 Antileishmanial agent-8Antileishmanial agent-8
Antileishmanial agent-8 (compound 18) shows potent and selective activity against Leishmania donovani ( L. donovani ) (IC50 = 5.64 μM) with relatively low cytotoxicity in L-6 cells (IC 50 =73.9 μM) [1].
价 格:¥电议型 号:T60638产 地:中国大陆