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  • T20939Bimatoprost acid17-phenyl trinor PGF2α；17-phenyl trinor Prostaglandin F2α

    Bimatoprost acid is a metabolically stable analog of PGF2α and has a potential antagonistic activity for the FP receptor. It has a relative potency of 756% compared to PGF2α for binding to the FP receptor on ovine luteal cells.

    价 格：￥电议型 号：T20939产 地：中国大陆

  • T3799617-phenyl trinor Prostaglandin E2 ethyl amide；17-phenyl trinor Prostaglandin E2 ethyl amide17-phenyl

    17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively). 17-phenyl trinor PGE2 causes contraction of guinea pig ileum at a concentration of 11 μM and is 4.4 times more potent than PGE2 as an antifertility agent in hamsters. Modification of the C-1 carboxyl group to an ethyl amide serves to inc

    价 格：￥电议型 号：T37996产 地：中国大陆

  • T3794817-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α；17-trifluoromethylphenyl-13,14-dihyd

    A number of 17-phenyl trinor prostaglandin F2α(17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.1,2,3Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.417-trifluoromethylphenyl-13,14-dihydro trinor PGF2αbears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As a

    价 格：￥电议型 号：T37948产 地：中国大陆

  • T3794717-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester；17-trifluoromethylphenyl trinor Prost

    Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 17-trifluoromethylphenyl trinor PGF2α is an analog of PGF2α that shares the meta-trifluoromethyl group of travoprost with the 17-phenyl trinor modification of latanoprost. It is anticipated to be a potent and selective agonist of the FP receptor, with potential applications in glaucoma and luteolysis. 17-trifluoromethylphenyl trinor PGF2α methyl ester is a lipophil

    价 格：￥电议型 号：T37947产 地：中国大陆

  • T3794617-trifluoromethylphenyl trinor Prostaglandin F2α；17-trifluoromethylphenyl trinor Prostaglandin F2α1

    A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists. 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trin

    价 格：￥电议型 号：T37946产 地：中国大陆

  • T37945Bimatoprost methyl ester；化合物 Bimatoprost methyl ester17-phenyl trinor Prostaglandin F2α methyl ester

    Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Bimatoprost methyl ester is a lipophilic analog of 17-phenyl trinor PGF2α, a potent agonist for the FP receptor. 17-phenyl trinor PGF2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α. Esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid.

    价 格：￥电议型 号：T37945产 地：中国大陆

  • T3794417-phenyl trinor Prostaglandin F2α methyl amide；17-phenyl trinor Prostaglandin F2α methyl amide17-ph

    17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor, binding with a relative potency of 756% compared to that of PGF2α. The ethyl amide of 17-phenyl trinor PGF2α bimatoprost has been approved for use as an ocular hypotensive drug. 17-phenyl trinor PGF2α methyl amide is an analog of bimatoprost. Its biological and toxicological properties have not been evaluated.

    价 格：￥电议型 号：T37944产 地：中国大陆

  • T3794317-phenyl trinor Prostaglandin F2α isopropyl ester；17-phenyl trinor Prostaglandin F2α isopropyl este

    17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost. This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP r

    价 格：￥电议型 号：T37943产 地：中国大陆

  • T3794217-phenyl trinor Prostaglandin F2α dimethyl amide；17-phenyl trinor Prostaglandin F2α dimethyl amide1

    17-phenyl trinor Prostaglandin F2αdimethyl amide is an isomer of 17-phenyl trinor prostaglandin F2αethyl amide.

    价 格：￥电议型 号：T37942产 地：中国大陆

  • T3794117-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide；17-phenyl trinor Prostaglandin F2α cyclo

    Prostaglandin F2α (PGF2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis. 17-phenyl trinor PGF2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α. It is produced in vivo by the hydrolysis of 17-phenyl trinor PGF2α ethyl amide. 17-phenyl trinor PGF2α ethyl amide is used to reduce intraocular pressure related to glaucoma. 17-phenyl trinor PGF2α cyclopropyl methyl amide is a lipophilic analog of 17-phenyl trinor PGF

    价 格：￥电议型 号：T37941产 地：中国大陆

  • T3794017-phenyl trinor Prostaglandin F2α cyclopropyl amide；17-phenyl trinor Prostaglandin F2α cyclopropyl

    17-phenyl trinor Prostaglandin F2α cyclopropyl amide (17-phenyl trinor PGF2α cyclopropyl amide) is a novel analog of 17-phenyl trinor PGF2α ethyl amide. There are no published reports on the biological activity of 17-phenyl trinor PGF2α cyclopropyl amide.

    价 格：￥电议型 号：T37940产 地：中国大陆

  • T37939N-Desethyl Bimatoprost；化合物 N-Desethyl Bimatoprost17-phenyl trinor Prostaglandin F2α amide；17-phenyl

    N-Desethyl Bimatoprost (17-phenyl trinor PGF2α amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs. Although it has been claimed that PG amides are not converted to the free acids in vivo, studies have shown that bovine and human corneal tissue converts the amides of various PGs to the free acids

    价 格：￥电议型 号：T37939产 地：中国大陆

  • T3793817-phenoxy trinor Prostaglandin F2α ethyl amide；17-phenoxy trinor Prostaglandin F2α ethyl amide17-ph

    Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. Both 17-phenyl trinor PGF2α and 16-phenoxy tetranor PGF2α are metabolically stable analogs of PGF2α and potent agonists for the FP receptor. 17-phenoxy trinor PGF2α ethyl amide is a lipophilic analog of 17-phenoxy trinor PGF2α . Ethyl amides of PGs serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid.

    价 格：￥电议型 号：T37938产 地：中国大陆

  • T3793415-keto-17-phenyl trinor Prostaglandin F2α；15-keto-17-phenyl trinor Prostaglandin F2α15-keto-17-phen

    Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compo

    价 格：￥电议型 号：T37934产 地：中国大陆

  • T3793015(R)-17-phenyl trinor Prostaglandin F2α；15(R)-17-phenyl trinor Prostaglandin F2α15(R)-17-phenyl tri

    17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2α ethyl amide. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 μg/cornea/24 hours. The free acid, 17-ph

    价 格：￥电议型 号：T37930产 地：中国大陆

  • T3777717-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide；17-trifluoromethylphenyl trinor Prosta

    Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 17-trifluoromethylphenyl trinor Prostaglandin F2α (17-trifluoromethylphenyl trinor PGF2α) is an analog of PGF2α that shares the meta-trifluoromethyl group of travoprost with the 17-phenyl trinor modification of latanoprost. It is anticipated to be a potent and selective agonist of the FP receptor, with potential applications in glaucoma and luteolysis. 17-trifluoro

    价 格：￥电议型 号：T37777产 地：中国大陆

  • T36908Bimatoprost grenod；化合物 Bimatoprost grenod15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α；1

    Bimatoprost grenod(15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α.1It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically administered at a concentration of 0.042%. Topical administration of 15-(6-nitroxylhexanoyl)-17-phenyl trinor PGF2α(0.14%) reduces intraocular hypertension (IOP) in a rabbit model of hypertonic saline-induced transient ocular pressure. It also reduces IOP in a cynomolgus monkey mode

    价 格：￥电议型 号：T36908产 地：中国大陆

  • T3594415-keto-17-phenyl trinor Prostaglandin F2α ethyl amide；15-keto-17-phenyl trinor Prostaglandin F2α et

    Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group produces 15-keto-17-phenyl trinor PGF2α ethyl amide. 15-keto-17-phenyl trinor PGF2α ethyl amide is a potential metabolite of 17-phenyl trinor PGF2α ethyl amide when 17-phenyl trinor PGF2α ethyl amide is administered to intact animals. No pharmacologi

    价 格：￥电议型 号：T35944产 地：中国大陆

  • T30452Bimatoprost isopropyl ester；化合物 T3045217-phenyl trinor PGF2α-iPr|||17-phenyl trinor PGF2α isopropyl

    Bimatoprost isopropyl ester is an F-series prostaglandin analog, which has been approved as a hypotensive drug.

    价 格：￥电议型 号：T30452产 地：中国大陆

  • T20939Bimatoprost acid；化合物Bimatoprost acid17-phenyl trinor PGF2α|||17-phenyl trinor Prostaglandin F2α；17-p

    Bimatoprost acid (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and has a potential antagonistic activity for the FP receptor. It has a relative potency of 756% compared to PGF2α for binding to the FP receptor on ovine luteal cells.

    价 格：￥电议型 号：T20939产 地：中国大陆

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