Product Description

The theoretical basis of FBDD is to ｓelect favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect ａnd manage. In addition, fragments have smaller molecular weights, relatively higher solubility, ａnd easier structural optimization. The potential of over-the-counter medicine is higher. In recent years, covalent chemical probes have become an important tool for drug discovery. A large number of successful applications in the evaluation of protein druggability, especially the successful application of Cys residues, bring hope for the discovery ａnd synthesis of new covalently modified compounds. To this end, we designed a cysteine-specific covalent library. The electrophilic "warhead" of the fragments is acrylamide or chloroacetamide (25% ａnd 75% of the library, respectively). These functional groups were chosen to construct the library because they are in the "best position" for reactivity ａnd show selectivity in chemical proteomics screening.
 

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品牌介绍：
TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化域科学家的研究提供业的产品和服务。TargetMol品牌的客户群分布于40多个国家和地区，已发展成为全球大的化合物库和小分子化合物研究供应商。