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  • T64377AGI-41998 tautomers；AGI-41998互变异构体AGI-41998 tautomers

    AGI-41998 tautomers is a tautomerism of pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]-. pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]- is a S-adenosylmethionine synthase isoform type-2 inhibitor, IC50= 0.022μM.

    价 格：￥电议型 号：T64377产 地：中国大陆

  • T64199PI3KC2α-IN-3；化合物 PI3KC2α-IN-3PI3KC2α-IN-3

    PI3KC2α-IN-3 is a highly selective and potent PI3KC2α inhibitor with an IC50 value of 126 nM. PI3KC2α-IN-3 interacts with the ATP binding site of PI3KC2α and impairs endocytic membrane kinetics and membrane remodelling. PI3KC2α-IN-3 can be used to study thrombosis, diabetes and cancer.

    价 格：￥电议型 号：T64199产 地：中国大陆

  • T63199Dalpiciclib hydrochloride；化合物 Dalpiciclib hydrochlorideDalpiciclib hydrochloride

    Dalpiciclib (SHR-6390) hydrochloride is a highly selective, orally active CDK4/6 inhibitor with IC50 values of 12.4 nM and 9.9 nM, respectively, and is capable of acting as an antitumor agent in breast and esophageal squamous cell carcinomas.

    价 格：￥电议型 号：T63199产 地：中国大陆

  • T62199Talnetant hydrochloride；化合物 Talnetant hydrochlorideTalnetant hydrochloride

    Talnetant (SB 223412) hydrochloride is a selective NK3 receptor antagonist that acts in hNK-3-CHO cells (Ki: 1.4 nM). Talnetant hydrochloride is 100 times more selective for the hNK-3 receptor than the hNK-2 receptor and has no affinity for hNK-1 at a concentration of 100 μM.

    价 格：￥电议型 号：T62199产 地：中国大陆

  • T61999Quinine hydrobromide；化合物 Quinine hydrobromideQuinine hydrobromide

    Quinidine is a potent, orally active, selective inhibitor of cytochrome P450db. Quinidine hydrobromide is a K + channel blocker (IC 50= 19.9 μM). Quinidine hydrobromide shows antiarrhythmic activity. Quinidine hydrobromide can be used for malaria research.

    价 格：￥电议型 号：T61999产 地：中国大陆

  • T61998UGM-IN-3；化合物 UGM-IN-3UGM-IN-3

    UGM-IN-3 (compound 10a) is a inhibitor of UDP-galactopyranose mutase (UGM) with a Kd of 66 μM. UGM-IN-3 inhibits the growth of Mycobacterium tuberculosis (MIC= 6.2 μg/mL).

    价 格：￥电议型 号：T61998产 地：中国大陆

  • T61996Antiproliferative agent-6；化合物 Antiproliferative agent-6Antiproliferative agent-6

    Antiproliferative agent-6 (compound 8a) is a potent antitumor compound. Antiproliferative agent-6 shows antiproliferative activity. Antiproliferative agent-6 inhibits cancer cell lines HCT116, MCF-7, H460 and non-tumor aneuploid immortal keratinocyte HaCaT cells with GI 50 s of 0.5 μM, 2 μM, 0.7 μM and 3.5 μM, respectively.

    价 格：￥电议型 号：T61996产 地：中国大陆

  • T61995Y-29794；化合物 Y-29794Y-29794

    Y-29794 (Compound 2) is a potent, covalent inhibitor of prolyl oligopeptidase (POP) (Ki= 0.95 nM). Y-29794 has research value in neurodegenerative diseases and cancer.

    价 格：￥电议型 号：T61995产 地：中国大陆

  • T61994AChE/BChE-IN-8；化合物 AChE/BChE-IN-8AChE/BChE-IN-8

    AChE/BChE-IN-8 (Compound 5a) is an uncompetitive AChE and mixed BChE inhibitor. AChE/BChE-IN-8 shows Ki of 0.788 μM and 2.364 μM against Electrophorus electricus AChE (EeAChE) and equine BChE (eqBChE), respectively. AChE/BChE-IN-8 has blood-brain barrier permeability and low cytotoxicity.

    价 格：￥电议型 号：T61994产 地：中国大陆

  • T61993SW-034538；化合物 SW-034538SW-034538

    SW-034538 is a TAO2 inhibitor (IC 50= 300 nM).

    价 格：￥电议型 号：T61993产 地：中国大陆

  • T61992SIK1 activator 1；化合物 SIK1 activator 1SIK1 activator 1

    SIK1 activator 1 can enhances the SIK1 phosphorylation and ameliorated the hyperglyceamia of type 2 diabetic mice. SIK1 activator 1 exhibited remarkable inhibitory activity on hepatic gluconeogenesis.

    价 格：￥电议型 号：T61992产 地：中国大陆

  • T61991HTT-D3；化合物 HTT-D3HTT-D3

    HTT-D3 is a potent and orally active huntingtin (HTT) splicing modulator. HTT-D3 can lead to HTT mRNA degradation and reduction of HTT levels. HTT-D3 reduces p-glycoprotein (P-gp) efflux, and has research value in Huntington´s disease.

    价 格：￥电议型 号：T61991产 地：中国大陆

  • T61990Topoisomerase I/II inhibitor 3；化合物 Topoisomerase I/II inhibitor 3Topoisomerase I/II inhibitor 3

    Topoisomerase I/II inhibitor 3 (compound 7) is a potent dual inhibitor of topoisomerase I (Topo I) and II (Topo II) . By inhibiting PI3K /Akt/mTOR signaling pathway, Topoisomerase I/II inhibitor 3 can inhibit cell proliferation, invasion and migration, and induce apoptosis . Topoisomerase I/II inhibitor 3 has research value in liver cancer.

    价 格：￥电议型 号：T61990产 地：中国大陆

  • T6199Ribociclib；瑞博西尼LEE011；瑞博西尼|||LEE011

    Ribociclib (LEE011) is a cell cycle protein-dependent kinase CDK4/6 inhibitor (IC50 = 10/39 nM) with specific and oral activity. Ribociclib has antitumor activity that blocks the cell cycle and inhibits tumor cell proliferation.

    价 格：￥电议型 号：T6199产 地：中国大陆

  • T60199NCRW0005-F05；化合物NCRW0005-F05NCRW0005-F05

    NCRW0005-F05 is a potent agonist of orphan G-protein coupled receptor GPR139 with an IC 50 value of 0.21 μM. NCRW0005-F05 can be used to research diabetes, obesity and Parkinson´s disease [1].

    价 格：￥电议型 号：T60199产 地：中国大陆

  • T5862Ezatiostat TFA；化合物Ezatiostat TFATER199(free base)|||Ezatiostat TFA (free base)|||Ezatiostat|||TLK199

    Ezatiostat TFA (TLK199) is a liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity.

    价 格：￥电议型 号：T5862产 地：中国大陆

  • T5199COH000；化合物COH000COH000

    COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).

    价 格：￥电议型 号：T5199产 地：中国大陆

  • T5097Ezatiostat；化合物EzatiostatTER199(free base)|||TLK199；TER199(free base)|||TLK199

    Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.

    价 格：￥电议型 号：T5097产 地：中国大陆

  • T4S1999Valepotriate；戊曲酯/缬草素Valtrate；戊曲酯/缬草素|||Valtrate

    Valepotriate (Valtrate) fraction can have sedative effects and affect behavioral parameters related to recognition memory. Valepotriates, a new class of cytotoxic and antitumor agents, they are very potent cytotoxic agents for the HTC hepatoma cells. Valepotriates may have a potential anxiolytic effect on the psychic symptoms of anxiety.

    价 格：￥电议型 号：T4S1999产 地：中国大陆

  • T4S1990Carvacrol香芹酚香荆芥酚|||Karvakrol|||O-Thymol|||cymophenol|||香芹酚

    1. Carvacrol (O-Thymol) presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. Carvacrol presents antidepressant effects, seems to be dependent on its interaction with the dopaminergic system, but not with the serotonergic and noradrenergic systems.

    价 格：￥电议型 号：T4S1990产 地：中国大陆

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