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T18598PROTAC BRD2/BRD4 degrader-1；化合物 T18598PROTAC BRD2/BRD4 degrader-1
PROTAC BRD2/BRD4 degrader-1 (compound 15) serves as a potent, selective degrader of BET proteins BRD4 and BRD2, achieving rapid, reversible, and unexpectedly selective elimination of BRD4 and BRD2 compared to BRD3. Its efficacy in suppressing solid tumors manifest with minimal cytotoxic effects. This compound comprises a BET inhibitor, a connecting linker, and thalidomide as the ligand for cereblon (CRBN)/cullin 4A[1].
价 格：￥电议型 号：T18598产 地：中国大陆
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T17728PROTAC CDK9 degrader-2；化合物 T17728PROTAC CDK9 degrader-2
PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].
价 格：￥电议型 号：T17728产 地：中国大陆
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T16667PROTAC Sirt2 Degrader-1；化合物 T16667PROTAC Sirt2 Degrader-1
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1].
价 格：￥电议型 号：T16667产 地：中国大陆
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T13850PROTAC BET degrader-3；化合物 T13850PROTAC BET degrader-3
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.
价 格：￥电议型 号：T13850产 地：中国大陆
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T13849PROTAC BET Degrader-1；化合物 T13849PROTAC BET Degrader-1
PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.
价 格：￥电议型 号：T13849产 地：中国大陆
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T13847PROTAC SGK3 degrader-1；PROTAC SGK3 降解剂1SGK3-PROTAC1；SGK3-PROTAC1
PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, which induces degradation of endogenous SGK3.PROTAC SGK3 degrader-1 inhibits GDC0941-induced proliferation of cancer cells.CAS ??5017-88-83-4
价 格：￥电议型 号：T13847产 地：中国大陆
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T13846PROTAC RIPK degrader-2；化合物 T13846PROTAC RIPK degrader-2
PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.
价 格：￥电议型 号：T13846产 地：中国大陆
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T13845PROTAC PARP1 degrader；化合物 T13845PROTAC PARP1 degrader
PROTAC PARP1 degrader is a degrader of PARP1 based on the PROTAC technology. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line (IC50 of 6.12 μM).
价 格：￥电议型 号：T13845产 地：中国大陆
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T13844PROTAC K-Ras Degrader-1；化合物 T13844PROTAC K-Ras Degrader-1
PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC.
价 格：￥电议型 号：T13844产 地：中国大陆
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T13842PROTAC IRAK4 degrader-1；化合物 T13842PROTAC IRAK4 degrader-1
PROTAC IRAK4 degrader-1 is a degrader of PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4).
价 格：￥电议型 号：T13842产 地：中国大陆
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T13840PROTAC FAK degrader 1；化合物 T13840PROTAC FAK degrader 1
PROTAC FAK degrader 1 is a selective and potent degrader of focal adhesion kinase (Fak) (IC50 of 6.5 nM).
价 格：￥电议型 号：T13840产 地：中国大陆
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T13839PROTAC ER Degrader-4；化合物 T13839PROTAC ER Degrader-4
PROTAC ER Degrader-4 is a PROATC degrader of estrogen receptor (ER)(IC50 of 0.8 nM).
价 格：￥电议型 号：T13839产 地：中国大陆
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T13838PROTAC CRABP-II Degrader-3；化合物 T13838PROTAC CRABP-II Degrader-3
PROTAC CRABP-II Degrader-3 is a potent degrader of cellular retinoic acid binding protein (CRABP-II) based on cIAp1.
价 格：￥电议型 号：T13838产 地：中国大陆
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T13837PROTAC CRABP-II Degrader-2；化合物 T13837PROTAC CRABP-II Degrader-2
PROTAC CRABP-II Degrader-2 is a potent degrader of cellular retinoic acid binding protein (CRABP-II) based on cIAp1.
价 格：￥电议型 号：T13837产 地：中国大陆
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T13836PROTAC CRABP-II Degrader-1；化合物 T13836PROTAC CRABP-II Degrader-1
PROTAC CRABP-II Degrader-1 is a potent degrader of cellular retinoic acid binding protein (CRABP-II) based on cIAp1.
价 格：￥电议型 号：T13836产 地：中国大陆
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T13835PROTAC BRD4 Degrader-3；化合物 T13835PROTAC BRD4 Degrader-3
PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4.
价 格：￥电议型 号：T13835产 地：中国大陆
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T13834PROTAC BRD4 Degrader-2；化合物 T13834PROTAC BRD4 Degrader-2
PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
价 格：￥电议型 号：T13834产 地：中国大陆
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T13833PROTAC BRD4 Degrader-1；化合物 T13833PROTAC BRD4 Degrader-1
PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).
价 格：￥电议型 号：T13833产 地：中国大陆
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T13722Homo-PROTAC pVHL30 degrader 1；化合物Homo-PROTAC pVHL30 degrader 1Homo-PROTAC pVHL30 degrader 1
Homo-PROTAC pVHL30 degrader 1 is a potent pVHL30 degrader based on PROTAC.
价 格：￥电议型 号：T13722产 地：中国大陆
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T13721Homo-PROTAC cereblon degrader 1；化合物Homo-PROTAC cereblon degrader 1Homo-PROTAC cereblon degrader 1
Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3.
价 格：￥电议型 号：T13721产 地：中国大陆
