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  • T35804C16 Lactosylceramide (d18:1/16:0)；C16 Lactosylceramide (d18:1/16:0)C16 Lactosylceramide (d18:1/16:0)

    C16 Lactosylceramide is an endogenous bioactive sphingolipid. It forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Plasma levels of C16 lactosylceramide are elevated in insulin-resistant cattle. C16 Lactosylceramide is also upregulated in a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder.

    价 格：￥电议型 号：T35804产 地：中国大陆

  • T35803C14 Ceramide (d18:1/14:0)；十四酰鞘氨醇Cer(d18:1/14:0)|||N-Myristoyl-D-sphingosine；Cer(d18:1/14:0)|||N-Myri

    C14 Ceramide (d18:1/14:0) is an endogenous ceramide produced by ceramide synthetase 6, which can be used for Parkinson´s research.

    价 格：￥电议型 号：T35803产 地：中国大陆

  • T35802ML-345；ML-345ML-345

    Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. [1] In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer´s disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM. [2]

    价 格：￥电议型 号：T35802产 地：中国大陆

  • T35801ML-262；ML-262ML-262

    ML-262 is an inhibitor of hepatic lipid droplet formation (IC50 = 6.4 nM in murine AML-12 cells), which is associated with non-alcoholic fatty liver disease. ML-262 does not induce cytotoxicity (up to 33 μM) or inhibit fatty acid uptake (up to 50 μM).

    价 格：￥电议型 号：T35801产 地：中国大陆

  • T35800MD001MD001MD-001|||MD001

    MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ.1 It binds to PPARα and PPARγ (Kds = 9.55 and 0.14 μM, respectively) but does not bind to PPARβ/δ at concentrations up to 500 μM. It increases transcriptional activity of PPARα and PPARγ in a cell-based luciferase reporter assay when used at a concentration of 10 μM. MD001 (10 μM) increases expression of PPARα, PPARγ, and retinoid X receptor (RXR), as well as PPARα and PPARγ target genes, in HepG2 cells. It

    价 格：￥电议型 号：T35800产 地：中国大陆

  • T3580FIPI；化合物FIPI5-Fluoro-2-indolyl deschlorohalopemide；5-Fluoro-2-indolyl deschlorohalopemide

    FIPI (5-Fluoro-2-indolyl deschlorohalopemide) is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM); prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis.

    价 格：￥电议型 号：T3580产 地：中国大陆

  • T35758Butyrolactone V；Butyrolactone VButyrolactone V

    Butyrolactone V is a fungal metabolite that has been found in A. terreus and has antiprotozoal, antioxidant, and anticancer activities.1,2,3 It is active against the P. falciparum strain K1 (IC50 = 7.9 μg/ml) and L. amazonensis promastigotes (IC50 = 23.7 μM).2,1 Butyrolactone V (227 and 454.1 μM) is also active against adult S. mansoni worms.1 It scavenges 2,2-diphenyl-1-picrylhydrazyl and ABTS radicals with IC50 values of 20.7 and 3.7 μM, respectively, in cell-free assays.3 Butyrolactone V also

    价 格：￥电议型 号：T35758产 地：中国大陆

  • T35589Geranyl pyrophosphate triammonium；Geranyl Pyrophosphate (triammonium salt)Geranyl pyrophosphate tria

    Geranyl pyrophosphate is an intermediate in the mevalonate pathway. It is formed from dimethylallyl pyrophosphate and isopentenyl pyrophosphate by geranyl pyrophosphate synthase. Geranyl pyrophosphate is used in the biosynthesis of farnesyl pyrophosphate , geranylgeranyl pyrophosphate , cholesterol, terpenes, and terpenoids.

    价 格：￥电议型 号：T35589产 地：中国大陆

  • T35588Ganglioside GM3 Mixture (sodium salt)；Ganglioside GM3 Mixture (sodium salt)Ganglioside GM3 Mixture (

    Ganglioside GM3 is a monosialoganglioside that demonstrates antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation. It suppresses angiogenesis and reduces proliferation and migration of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 20 μM via inhibition of VEGFR2 and Akt phosphorylation. Ganglioside GM3 induces dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functi

    价 格：￥电议型 号：T35588产 地：中国大陆

  • T35587Ganglioside GD1a mixture (sodium salt)；Ganglioside GD1a mixture (sodium salt)Ganglioside B1；Ganglios

    Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver. [1] It can be shed from the surface of tumor cells into the microenvironment where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis. Ganglioside GD1a (20 μM) also increases endothelial cell proliferation. Furthermore, ganglioside GD1a has been shown to act as a functional coreceptor for toll-like receptor 2 (T

    价 格：￥电议型 号：T35587产 地：中国大陆

  • T35586I-SAP；I-SAPI-SAP

    I-SAP is a high affinity TP receptor antagonist. At physiologic pH, I-SAP produces platelet shape change, but not aggregation, with an EC50 value of 9.7 nM. I-SAP binds to human platelets with the maximum binding obtained between pH 6.5 and pH 7.4. In washed human platelets, the Kd for I-SAP is 468 pM at pH 7.4 and 490 pM at pH 6.5.

    价 格：￥电议型 号：T35586产 地：中国大陆

  • T35585I-BOPI-BOPI BOP|||IBOP

    I-BOP is an agonist (KD=0.61 nM) at the thromboxane A2 receptor (TP). I-BOP promotes cell proliferation by activating the PI3K pathway in vascular smooth muscle.

    价 格：￥电议型 号：T35585产 地：中国大陆

  • T35584Hydroxydehydro Nifedipine Carboxylate；Hydroxydehydro Nifedipine CarboxylateHydroxydehydro Nifedipine

    Hydroxydehydro nifedipine carboxylate is a metabolite of nifedipine .1

    价 格：￥电议型 号：T35584产 地：中国大陆

  • T35583Hirudin (54-65; non-sulfated) (trifluoroacetate salt)；Hirudin (54-65; non-sulfated) (trifluoroacetat

    Hirudin (54-65; non-sulfated) is a desulfated peptide fragment of hirudin, an anticoagulant produced byH. medicinalis.1It inhibits fibrin clot formation induced by isolated bovine thrombin with an IC50value of 3.7 μM.2

    价 格：￥电议型 号：T35583产 地：中国大陆

  • T35582H-Arg-Gly-Asp-Cys-OH (trifluoroacetate salt)；H-Arg-Gly-Asp-Cys-OH (trifluoroacetate salt)H-Arg-Gly-A

    H-Arg-Gly-Asp-Cys-OH is a tetrapeptide that contains the arginine-glycine-aspartate (RGD) motif, a sequence that acts as a recognition site for various adhesion proteins.1It inhibits the binding of fibrinogen to endothelial cells and ADP-stimulated platelets with IC50values of 320 and 35 μM, respectively.2Implantation of titanium rods coated with H-Arg-Gly-Asp-Cys-OH increases bone formation in rat femurs.3H-Arg-Gly-Asp-Cys-OH has been conjugated to polyethylenimine to improve gene transfection

    价 格：￥电议型 号：T35582产 地：中国大陆

  • T35581PrazobindPrazobindPrazobind

    Prazobind is a prazosinoid substance that blocks insulin stimulation of IP1 (inositol phosphate) accumulation and is an effective α1 adrenoceptor blocker.

    价 格：￥电议型 号：T35581产 地：中国大陆

  • T35580POV-PC；POV-PCPOV-PC

    Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. 1-(Palmitoyl)-2-(5-oxovaleroyl)-phosphatidylcholine, or POV-PC, is one of the oxLDL species derived from 2-arachidonoyl or eicosapentanoyl phospholipids. POV-PC conf

    价 格：￥电议型 号：T35580产 地：中国大陆

  • T3558EBE-A22；化合物EBE-A22PD153035 Analog 63；PD153035 Analog 63

    EBE-A22 (PD153035 Analog 63) is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive.

    价 格：￥电议型 号：T3558产 地：中国大陆

  • T35558KAAD-CyclopamineCyclopamine-KAADKAAD Cyclopamine|||KAADCyclopamine

    Cyclopamine-KAAD is a potent inhibitor of hedgehog signaling with an IC50 value of 20 nM in a Shh-LIGHT2 assay. It blocks binding of BODIPY-cyclopamine to cells expressing Smoothened (Smo) in a dose-dependent manner. Cyclopamine-KAAD is cell-permeable and binds to SmoA1 to promote its exit from the endoplasmic reticulum. It inhibits the invasion and migration (45.9 and 43.3% inhibition, respectively) of Bel-7402 hepatocarcinoma cells and decreases the expression of nuclear glioma-associated onco

    价 格：￥电议型 号：T35558产 地：中国大陆

  • T35458(R)-nitro-Blebbistatin；(R)-nitro-Blebbistatin(R)-nitro-Blebbistatin

    (R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin , which is the inactive form of (-)-blebbistatin . Prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. The addition of a nitro group stabilizes the molecule to circumvent its degradation by prolonged blue light exposure. (R)-nitro-Blebbistatin has the same stereoche

    价 格：￥电议型 号：T35458产 地：中国大陆

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