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  • T79905Akt/ROCK-IN-1；化合物 Akt/ROCK-IN-1Akt/ROCK-IN-1

    Akt/ROCK-IN-1 (B12) is a dual inhibitor targeting Akt and ROCK, exhibiting IC50 values of 0.023 nM and 1.47 nM, respectively. It possesses antitumor efficacy against neuroblastoma [1].

    价 格：￥电议型 号：T79905产 地：中国大陆

  • T79632Antileishmanial agent-21；化合物 Antileishmanial agent-21Antileishmanial agent-21

    Antileishmanial agent-21 (compound 4e) functions as an inhibitor of Leishmania pteridine reductase 1 (Lm-PTR1), employing an anti-folate mechanism. Its antileishmanial effects can be negated by folic acid and leucovorin. Additionally, it demonstrates inhibitory activity against the chloroquine-resistant Plasmodium falciparum strain RKL9, with an IC50 ranging from 0.0198 to 0.096 μM [1].

    价 格：￥电议型 号：T79632产 地：中国大陆

  • T79590Anti-neuroinflammation agent 1；化合物 Anti-neuroinflammation agent 1Anti-neuroinflammation agent 1

    Anti-neuroinflammation Agent 1 effectively modulates BV2 microglia cell polarization, shifting from an M1 to an M2 phenotype [1].

    价 格：￥电议型 号：T79590产 地：中国大陆

  • T79589Antifungal agent 71；化合物 Antifungal agent 71Antifungal agent 71

    Antifungal agent 71 (compound 6r), a trifluoromethyl pyrimidine derivative, displays potent in vitro activity against F. oxysporum, evidenced by an EC 50 value of 3.61 μg/mL [1].

    价 格：￥电议型 号：T79589产 地：中国大陆

  • T79569AChE/Aβ-IN-1；化合物 AChE/Aβ-IN-1AChE/Aβ-IN-1

    AChE/Aβ-IN-1 (compound 32) is a potent, orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 86 nM and an NMDA receptor antagonist targeting the GluN1-1b/GluN2B subunit combination with an IC50 of 3.876 μM. Additionally, it impedes Aβ aggregation, exhibits favorable blood-brain barrier permeability, offers neuroprotection, and enhances cognitive and spatial memory in rat models [1].

    价 格：￥电议型 号：T79569产 地：中国大陆

  • T79513ABCG2-IN-1；化合物 ABCG2-IN-1ABCG2-IN-1

    ABCG2-IN-1 (compound K2), an analog of Ko143, constitutes an orally active inhibitor targeting ABCG2 with an inhibitory concentration (IC50) of 0.13 μM. Demonstrating favorable oral pharmacokinetics in mice, ABCG2-IN-1 showcases promise for further research [1].

    价 格：￥电议型 号：T79513产 地：中国大陆

  • T7948HPGDS inhibitor 2化合物GSK-2894631AGSK-2894631A

    HPGDS inhibitor 2 (GSK-2894631A) is a potent, selective hematopoietic prostaglandin D synthase (h-pgds) inhibitor, IC50 = 9.9 nm.

    价 格：￥电议型 号：T7948产 地：中国大陆

  • T79466Antitumor agent-111；化合物 Antitumor agent-111Antitumor agent-111

    Antitumor Agent-111 (Compound 46), a c-Met kinase inhibitor (IC50 = 46 nM), exhibits both antitumor and antiproliferative effects. It impedes the cell cycle at the G0/G1 phase and induces apoptosis [1].

    价 格：￥电议型 号：T79466产 地：中国大陆

  • T79454Anti-NASH agent 1；化合物 Anti-NASH agent 1Anti-NASH agent 1

    Anti-NASH Agent 1 (Compound 3d), derived from Elafibranor, serves as a strong PPAR-α/δ agonist aimed at treating nonalcoholic steatohepatitis (NASH). At dosages of 3-10 mg/kg over four weeks, this compound ameliorates hyperlipidemia, liver fat degeneration, and inflammation in a methionine-choline deficiency (MCD)-induced NASH mouse model, exhibiting minimal hepatotoxicity while providing substantial hepatic protection [1].

    价 格：￥电议型 号：T79454产 地：中国大陆

  • T79392ALK/EGFR-IN-1；化合物 ALK/EGFR-IN-1ALK/EGFR-IN-1

    ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation. It demonstrates potent inhibition of ALK/EGFR mutants with IC50 values of 4.3 nM for EGFR L858R T790M in H1975 cells and 3.6 nM for EML4-ALK in BaF3 cells. This compound may be applicable in the research of non-small cell lung cancer (NSCLC) [1].

    价 格：￥电议型 号：T79392产 地：中国大陆

  • T79372A3AR agonist 1；化合物 A3AR agonist 1A3AR agonist 1

    A3AR Agonist 1 (Compound 12), with a Ki of 25.8 nM, is a potent A3 adenosine receptor (A3AR) agonist that promotes β-arrestin2 recruitment with an effective concentration (EC50) of 5.17 nM. It serves as a research tool in various pathological conditions, including inflammatory diseases, ischemia, cancer, neuropathic pain, and liver diseases [1].

    价 格：￥电议型 号：T79372产 地：中国大陆

  • T79335Antimalarial agent 31；化合物 Antimalarial agent 31Antimalarial agent 31

    Compound 31 (compound 7k) is an orally active inhibitor of Plasmodium falciparum aspartic protease, plasmepsin X (PMX), with antimalarial properties [1].

    价 格：￥电议型 号：T79335产 地：中国大陆

  • T79298Antifungal agent 61；化合物 Antifungal agent 61Antifungal agent 61

    Antifungal Agent 61 (Compound 38) is an antifungal agent that inhibits V. mali, with an EC50 value of 0.50 mg/L. This compound impedes V. mali´s growth by inducing cell deformation and contraction, diminishing intracellular mitochondrial count, thickening the cell wall, and enhancing cell membrane permeability [1].

    价 格：￥电议型 号：T79298产 地：中国大陆

  • T79249Antitumor agent-101；化合物 Antitumor agent-101Antitumor agent-101

    Antitumor agent-101 is a selective, covalent inhibitor targeting lysine methyltransferases G9a/GLP, demonstrating IC50 values of 8.5 nM for G9a and 5.5 nM for GLP. It exhibits antitumor efficacy in the PANC-1 xenograft model [1].

    价 格：￥电议型 号：T79249产 地：中国大陆

  • T79226AMPK activator 11；化合物 AMPK activator 11AMPK activator 11

    AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-activated protein kinase (AMPK) and enhancement of oxidative phosphorylation (OXPHOS) (mitochondrial metabolism). This compound demonstrates particular efficacy in inhibiting RKO xenograft growth, rendering it useful for anti-tumor and metabolic disease research [1].

    价 格：￥电议型 号：T79226产 地：中国大陆

  • T79203Anticancer agent 121；化合物 Anticancer agent 121Anticancer agent 121

    Anticancer agent 121, a human lactate dehydrogenase A (hLDHA) inhibitor, exhibits potent anticancer activities, suitable for use in anticancer research [1].

    价 格：￥电议型 号：T79203产 地：中国大陆

  • T7911Arbidol；化合物 T7911Arbidol

    Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir both suppresses virus propagation and modulates the expression of inflammatory cytokines and is used as an anti-influenza virus agent [3]. Umifenovir could effectively inhibit the fusion of virus with host cells [1] [2]. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro [2].

    价 格：￥电议型 号：T7911产 地：中国大陆

  • T79031ATR-IN-21；化合物 ATR-IN-21ATR-IN-21

    ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].

    价 格：￥电议型 号：T79031产 地：中国大陆

  • T78976Antibacterial agent 141；化合物 Antibacterial agent 141Antibacterial agent 141

    Compound B14 (Antibacterial agent 141) exhibits antibacterial activity against the plant pathogens Xoo, Xac, Psa, and Cmm, with an EC50 value of 1.28 μM. It functions by inhibiting cell membrane formation and altering cell permeability.

    价 格：￥电议型 号：T78976产 地：中国大陆

  • T78972Anticancer agent 111；化合物 Anticancer agent 111Anticancer agent 111

    Anticancer agent 111 (compound 11), exhibiting anticancer activity, serves as a potent inhibitor of cytochrome P450, particularly targeting CYP3A4 with an inhibitory concentration (IC50) of 3 μM. It is useful in cancer research [1].

    价 格：￥电议型 号：T78972产 地：中国大陆

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