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T41159NCT 501 hydrochloride;NCT 501 hydrochlorideNCT 501 hydrochloride
NCT 501 hydrochloride is a potent and selective ALDH1A1 inhibitor (IC50 = 40 nM). Exhibits >1000-fold selectivity for ALDH1A1 over ALDH3A1, ALDH1B1, ALDH2, HPGD and HSD17β4. Also selective over a panel of 168 GPCRs. Blood-brain barrier permeable.
价 格:¥电议型 号:T41159产 地:中国大陆
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T40654Avatrombopag hydrochloride;Avatrombopag hydrochlorideAKR-501 hydrochloride|||YM477hydrochloride|||E5
Avatrombopag hydrochloride (AKR-501) is an orally active, nonpeptide agonist of the thrombopoietin (TPO) receptor with an EC 50 of 3.3 nM. It effectively mimics the biological activities of TPO, stimulating platelet production by activating the intracellular signaling system and facilitating the generation of platelets and megakaryocytes from hemopoietic precursor cells. Additionally, Avatrombopag hydrochloride serves as a substrate for cytochrome P450 (CYP) 2C9 and CYP3A.
价 格:¥电议型 号:T40654产 地:中国大陆
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T40501Erucifoline;ErucifolineErucifoline
Erucifoline, a pyrrolizidine alkaloid, is present in the aerial components of Senecio aquaticus.
价 格:¥电议型 号:T40501产 地:中国大陆
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T39927Zeteletinib hemiadipateZeteletinib hemiadipateBOS-172738 hemiadipate|||DS-5010hemiadipate|||Zeteleti
Zeteletinib hemiadipate (BOS-172738; DS-5010) is an orally active compound that functions as a selective inhibitor of RET kinase. It exhibits nanomolar potency against RET and a 300-fold selectivity towards VEGFR2. Notably, Zeteletinib hemiadipate demonstrates exceptional effectiveness against various forms of RET, including the wild type, RET V804M/L gatekeeper mutants, and the oncogenic RET mutation M918T. Additionally, Zeteletinib hemiadipate exerts potent antitumor effects.
价 格:¥电议型 号:T39927产 地:中国大陆
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T3987Lotamilast;化合物LotamilastE6005|||RVT-501;E6005|||RVT-501
Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.
价 格:¥电议型 号:T3987产 地:中国大陆
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T39501Anticancer agent 7;Anticancer agent 7Anticancer agent 7
Anticancer agent 7 (Example 5) is an anti-cancer agent that exhibits potent anticancer activity against H1650 lung cancer cells, with an IC50 value of 5 μM.
价 格:¥电议型 号:T39501产 地:中国大陆
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T39485NCT-501 hydrochloride;NCT-501 hydrochlorideNCT-501 hydrochloride
NCT-501 hydrochloride is a highly potent and selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), which is based on theophylline. It effectively inhibits hALDH1A1 with an IC50 value of 40 nM, exhibiting superior selectivity towards hALDH1A1 compared to other ALDH isozymes and dehydrogenases such as hALDH1B1, hALDH3A1, and hALDH2 (with IC50 values exceeding 57 μM).
价 格:¥电议型 号:T39485产 地:中国大陆
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T38501Fmoc-Phe-Lys(Trt)-PAB;Fmoc-Phe-Lys(Trt)-PABFmoc-Phe-Lys(Trt)-PAB
Fmoc-Phe-Lys(Trt)-PAB is a cleavable linker for antibody-drug conjugates (ADCs) synthesis.
价 格:¥电议型 号:T38501产 地:中国大陆
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T37501Ethoxyacetic acid;乙氧基乙酸Ethoxyacetic acid
Ethoxyacetic acid is an endogenous metabolite of ethylene glycol monoethyl ether acetate.
价 格:¥电议型 号:T37501产 地:中国大陆
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T36501CYPMPO;CYPMPORR 071;RR 071
CYPMPO is a free radical spin trap with excellent trapping capabilities toward hydroxyl and superoxide radicals in biological and chemical systems. Decay of the superoxide adduct of CYPMPO proceeds in an apparent first order fashion with half-lives of 15 and 51 minutes in a UV-illuminated hydrogen peroxide solution and a hypoxanthine/xanthine oxidase system, respectively. CYPMPO traps superoxide radicals generated by bovine neutrophils as effectively as DEPMPO.[1] The high melting point (126°C),
价 格:¥电议型 号:T36501产 地:中国大陆
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T3625Bempedoic acid;化合物ETC1002ETC1002|||ESP-55016|||ETC 1002|||ETC-1002;ETC1002|||ESP-55016|||ETC 1002|||
Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic acid(ETC1002) is absorbed rapidly in the small intestine and enters the liver through cell surface receptors different from those transporters that selectively take up statins. Bempedoic acid(ETC1002) is a regulator of lipid and carbohydrate metabolism.
价 格:¥电议型 号:T3625产 地:中国大陆
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T3619VU0357017 hydrochloride;盐酸 VU 0357017ML071 hydrochloride|||CID-25010775|||VU 0357017 hydrochloride;M
VU0357017 hydrochloride (ML071 hydrochloride) is highly selective M1 agonists act at an allosteric site to activate the receptor (EC50: 477 ± 172 nM; Pec50: 6.37 ± 0.15).
价 格:¥电议型 号:T3619产 地:中国大陆
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T355015,6-trans-Vitamin D3;5,6-反式维生素 D35,6-trans-Colecalciferol|||5,6-trans-Cholecalciferol|||Cholecalcife
5,6-trans-Vitamin D3(5,6-trans-Cholecalciferol) is an isoform of Vitamin D3, which is converted from Vitamin D3 on the skin surface after light exposure.
价 格:¥电议型 号:T35501产 地:中国大陆
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T35113WAY 150138;化合物 T35113WAY150138|||WAY-150138;WAY150138|||WAY-150138
WAY 150138 inhibits the herpes simplex virus.
价 格:¥电议型 号:T35113产 地:中国大陆
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T35016Valeramide, N-(5-(p-aminophenoxy)pentyl)-5-phenyl-;化合物 T35016Valeramide, N-(5-(p-aminophenoxy)pentyl
Valeramide, N-(5-(p-aminophenoxy)pentyl)-5-phenyl- is a bioactive chemical.
价 格:¥电议型 号:T35016产 地:中国大陆
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T35014Valdice;化合物 T35014Valdice
Valdice is a village and municipality in Ji?ín District in the Hradec Králové Region of the Czech Republic.
价 格:¥电议型 号:T35014产 地:中国大陆
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T35013Valconazole;化合物 T35013Valconazole
Valconazole is a bioactive chemical.
价 格:¥电议型 号:T35013产 地:中国大陆