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T62646Pparδ agonist 5；化合物 Pparδ agonist 5Pparδ agonist 5
Pparδ agonist 5 is a selective, orally active PPARδ agonist with an EC50 of 0.335 μM and better selectivity than GW0742. Pparδ agonist 5 has a beneficial effect on the improvement of bone density and microarchitecture in vivo.
价 格：￥电议型 号：T62646产 地：中国大陆
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T61646EGFR-IN-52；化合物 EGFR-IN-52EGFR-IN-52
EGFR-IN-52 (Compound 4) is a highly effective inhibitor of the epidermal growth factor receptor (EGFR). It exhibits IC50 values of 0.358, 86.02, and 432.67 μM against EGFR, EGFR L858R-TK, and EGFR T790M-TK, respectively. Additionally, EGFR-IN-52 demonstrates potent cytotoxic effects on cancer cell lines and triggers apoptosis [1].
价 格：￥电议型 号：T61646产 地：中国大陆
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T61527GSK2646264；化合物 GSK2646264GSK2646264
GSK2646264 (Compound 44) is a highly effective and specific inhibitor of spleen tyrosine kinase (SYK) with a pIC50 of 7.1. In addition to targeting SYK, GSK2646264 also inhibits several other kinases, including LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B, and Aurora A, with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3, respectively. Notably, GSK2646264 demonstrates skin penetrability, reaching both the epidermis and dermis [1].
价 格：￥电议型 号：T61527产 地：中国大陆
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T60646PCSK9 modulator-3；化合物 PCSK9 modulator-3PCSK9 modulator-3
PCSK9 modulator-3 (Compound 13) is a potent PCSK9 modulator with an EC 50 value of 2.46 nM that has the potential in the hyperlipidemia research. PCSK9 is a recently proved target for lowering low-density lipoprotein cholesterol (LDL-C) [1].
价 格：￥电议型 号：T60646产 地：中国大陆
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T5646Cinnamic acid；肉桂酸3-Phenylacrylic acid|||β-Phenylacrylic acid；3-Phenylacrylic acid|||β-Phenylacrylic
Cinnamic acid (β-Phenylacrylic acid) has potential use in cancer intervention,The concentration causing a 50% reduction of cell proliferation (IC50) ranged from 1 to 4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.
价 格：￥电议型 号：T5646产 地：中国大陆
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T4654(±)-Ibipinabant；化合物SLV319(±)-BMS6462|||SLV319|||(±)-SLV319；(±)-BMS6462|||SLV319|||(±)-SLV319
(±)-Ibipinabant ((±)-SLV319) has been used in trials studying the treatment of Obesity and Obesity and Type 2 Diabetes.
价 格：￥电议型 号：T4654产 地：中国大陆
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T4646TA-02；化合物TA-02TA-02
TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.
价 格：￥电议型 号：T4646产 地：中国大陆
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T4186AC-264613；化合物AC264613AC264613；AC264613
AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613(AC264613) suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages. AC-264613(AC264613) activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 30 to 100 nM.
价 格：￥电议型 号：T4186产 地：中国大陆
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T4132BPTU；化合物BPTUBMS-646786；BMS-646786
BPTU (BMS-646786) is an allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). Non-nucleotide ligand. Binds receptor outside of the helical bundle. Blocks inhibition of spontaneous contraction of rat and mouse colon induced by electrical field stimulation, nicotine and P2Y agonists. Antithrombotic; reduces platelet aggregation.
价 格：￥电议型 号：T4132产 地：中国大陆
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T41197Phalloidin-Janelia Fluor?646；Phalloidin-Janelia Fluor?646Phalloidin-Janelia Fluor?646|||Phalloidin-J
Phalloidin-Janelia Fluor?646 is a red fluorescent F-actin probe. Phalloidin-Janelia Fluor?646 is composed of the F-actin probe, Phalloidin, conjugated to Janelia Fluor?646. It is suitable for use in confocal and super-resolution microscopy techniques such as dSTORM. Excitation/emission maximum λ = 646/664 nm.
价 格：￥电议型 号：T41197产 地：中国大陆
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T41153BOP-JF646；BOP-JF646BOP-JF646；BOP-JF646
BOP-JF646 is a fluorescent dual α9β1/α4β1 integrin inhibitor. Comprises BOP conjugated to Janelia Fluor?646. Fluorogenic: fluoresces only once bound to integrins, enabling hassle-free no-wash experiments. Bright and photostable, enabling live cell tracking of integrin receptors over long time-course experiments. Excitation maximum = 655 nm; emission maximum = 672 nm.
价 格：￥电议型 号：T41153产 地：中国大陆
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T40646Lipoteichoic acid；脂磷壁酸Lipoteichoic acid
Lipoteichoic acid, a polymer of Staphylococcus aureus cell wall, activates the complement system by inducing C3 and inhibiting CD55, and reduces fat deposition via the IGF-1 pathway.
价 格：￥电议型 号：T40646产 地：中国大陆
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T39646Atinvicitinib；AtinvicitinibAtinvicitinib
Atinvicitinib, a pyrazole compound, exhibits promise for investigating atopic dermatitis.
价 格：￥电议型 号：T39646产 地：中国大陆
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T39504PA Janelia Fluor? 646, SE；PA Janelia Fluor? 646, SEPA-JF646-NHS；PA-JF646-NHS
PA Janelia Fluor 646, SE (PA-JF646-NHS), a photoactivatable fluorescent dye, is an NHS ester for coupling to primary amine groups. PA-JF646-NHS is non-fluorescent until activated at 365 nm. NHS ester can be converted to relevant substrate for use in self-labeling tag systems, e.g.HaloTag and SNAP-tag . PA-JF646-NHS is used for single molecule tracking and super resolution microscopy in live cells, specifically live cell sptPALM and fixed cell PALM. (λ Excitation/emission ~650/664 nm).
价 格：￥电议型 号：T39504产 地：中国大陆
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T38646GKT136901 hydrochloride；GKT136901 hydrochlorideGKT136901 hydrochloride；GKT136901 hydrochloride
GKT136901 hydrochloride is a powerful, selective, and orally active inhibitor of NADPH oxidase (NOX1/4). It exhibits K i values of 160 nM and 165 nM against NOX1 and NOX4, respectively. Additionally, GKT136901 hydrochloride demonstrates selectivity and direct scavenging ability towards peroxynitrite. This compound finds utility in studying diabetic nephropathy, stroke, neurodegeneration, and possesses anti-inflammatory properties.
价 格：￥电议型 号：T38646产 地：中国大陆
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T37646HB007；HB007HB007
HB007 is a potent degrader of small ubiquitin-related modifier 1 (SUMO1). It mediates the ubiquitination and subsequent degradation of SUMO1, leading to a decrease in tumor growth in vivo. HB007 is a valuable tool for investigating brain, breast, colon, and lung cancers[1][2].
价 格：￥电议型 号：T37646产 地：中国大陆
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T36646Trastuzumab deruxtecan；德曲妥珠单抗DS-8201a|||VRN-101099|||DS 8201|||T-DXd；DS-8201a|||VRN-101099|||DS 8201
Trastuzumab deruxtecan (T-DXd) is an antibody-activated molecule coupling (ADC) with anticancer and antitumour activity.Trastuzumab deruxtecan has been shown to have an ameliorative effect in HER2-positive breast and gastric cancers.
价 格：￥电议型 号：T36646产 地：中国大陆
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T36469Atrazine Mercapturate；Atrazine MercapturateAtrazine Mercapturate
Atrazine mercapturate is a major, glutathione-derived metabolite of atrazine , an herbicide that is effective in controlling a broad range of weeds. Atrazine has been reported to cause cancer in certain laboratory animals, have diverse effects on the reproductive system in animals and humans, and disrupt the normal function of the endocrine system. Atrazine mercapturate is readily measured in urine samples.
价 格：￥电议型 号：T36469产 地：中国大陆
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T36468ARN14988ARN14988ARN14988|||ARN-14988
ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 μM, respectively).
价 格：￥电议型 号：T36468产 地：中国大陆
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T36467Chrysomycin A；Chrysomycin AChrysomycin A
Chrysomycin A is an antibiotic that can be derived from Streptomyces. Chrysomycin A, Chrysomycin A inhibits cancer cell proliferation, migration, and invasion through the Akt/GSK-3β/β-catenin signaling pathway. Exhibits antitumor antituberculosis and MRSA activity.
价 格：￥电议型 号：T36467产 地：中国大陆
