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T6202DAPT；化合物DAPTLY-374973|||GSI-IX；LY-374973|||GSI-IX
DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis.
价 格：￥电议型 号：T6202产 地：中国大陆
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T61601TLR7/8 antagonist 2；化合物 TLR7/8 antagonist 2TLR7/8 antagonist 2
TLR7/8 antagonist 2 (Compound 15) is a highly potent and orally active agonist of TLR7/8, exhibiting IC50 values of 4.9 and 0.6 nM for TLR7 and TLR8, respectively. Its strong affinity for these receptors makes it a promising candidate for the treatment and investigation of autoimmune diseases, including lupus erythematosus, which is associated with inappropriate activation of TLR7 and TLR8. Consequently, TLR7/8 antagonist 2 represents a valuable tool for research in the field of autoimmune disea
价 格：￥电议型 号：T61601产 地：中国大陆
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T60977TL8-506；化合物 TL8-506TL8-506
TL8-506 can be used in autoimmune diseases and tuberculosis research which is a specific agonist of TLR8 (EC 50 = 30 nM) [1].
价 格：￥电议型 号：T60977产 地：中国大陆
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T60894TLR7/8 agonist 4；化合物 TLR7/8 agonist 4TLR7/8 agonist 4
TLR7/8 agonist 4 (compound 41) is a potent agonist of TLR7/8 with anti-cancer activity [1].
价 格：￥电议型 号：T60894产 地：中国大陆
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T60688MKI-1；化合物MKI-1MASTL Kinase Inhibitor-1；MASTL Kinase Inhibitor-1
MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, IC50= 9.9 μM). MKI-1 exerts radiosensitizer and antitumor activities through PP2A activation in breast cancer.
价 格：￥电议型 号：T60688产 地：中国大陆
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T60565(2R,5S)-Ritlecitinib；化合物 (2R,5S)-Ritlecitinib(2R,5S)-Ritlecitinib
(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective inhibitor of JAK3 with IC 50 of 144.8 nM[1].
价 格：￥电议型 号：T60565产 地：中国大陆
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T6023Nutlin-3a；化合物Nutlin-3a(-)-Nutlin-3|||Nutlin-3a chiral|||(?)-Nutlin-3；(-)-Nutlin-3|||Nutlin-3a chiral
Nutlin-3a ((?)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein.
价 格：￥电议型 号：T6023产 地：中国大陆
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T6007Birinapant比瑞那帕TL32711|||比瑞那帕
Birinapant (TL32711) is a synthetic small molecule that is both a peptidomimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.
价 格：￥电议型 号：T6007产 地：中国大陆
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T5862Ezatiostat TFA；化合物Ezatiostat TFATER199(free base)|||Ezatiostat TFA (free base)|||Ezatiostat|||TLK199
Ezatiostat TFA (TLK199) is a liposomal small-molecule glutathione analog inhibitor of glutathione S-transferase (GST) P1-1 with hematopoiesis-stimulating activity.
价 格：￥电议型 号：T5862产 地：中国大陆
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T5561TLR7/8 agonist 1 dihydrochloride；二盐酸TLR7/8 agonist 1TLR7/8 agonist-5d；TLR7/8 agonist-5d|||二盐酸TLR7/8
TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities.
价 格：￥电议型 号：T5561产 地：中国大陆
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T5382Ritlecitinib；化合物PF-06651600PF-06651600；PF-06651600
Ritlecitinib (PF-06651600) is a potent JAK3-selective inhibitor (IC50: 33.1 nM).
价 格：￥电议型 号：T5382产 地：中国大陆
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T5097Ezatiostat；化合物EzatiostatTER199(free base)|||TLK199；TER199(free base)|||TLK199
Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.
价 格：￥电议型 号：T5097产 地：中国大陆
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T4265AZD4635；化合物AZD4635HTL1071；HTL1071
AZD4635 (HTL1071) is a new-type adenosine 2A receptor (A2AR) inhibitor(Ki=1.7 nM).
价 格：￥电议型 号：T4265产 地：中国大陆
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T4258TLR7 agonist 2；化合物TLR7-agonist-1TLR7-agonist-1|||TLR7-IN-1；TLR7-agonist-1|||TLR7-IN-1
TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
价 格：￥电议型 号：T4258产 地：中国大陆
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T4231MD2-IN-1；化合物MD2-IN-1inhibit|||MD2-IN-1|||Inhibitor|||MD2IN1|||Toll-like Receptor (TLR)|||MD-2-IN-1||
MD2-IN-1 is a Myeloid differentiation protein 2 (MD2) inhibitor with a KD of 189 ?μM for the recombinant human MD2 (rhMD2).
价 格：￥电议型 号：T4231产 地：中国大陆
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T41234LY 379268 disodium salt；LY 379268 disodium saltLY 379268 disodium salt
LY 379268 disodium salt is a sodium salt of LY 379268, a highly selective group II mGlu receptor agonist.
价 格：￥电议型 号：T41234产 地：中国大陆
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T40891ADTL-SA1215；ADTL-SA1215ADTL-SA1215；ADTL-SA1215
ADTL-SA1215 is a novel, highly selective small-molecule compound that acts as a specific activator of SIRT3, a protein known to play a crucial role in modulating autophagy. This compound holds great potential in the treatment of triple-negative breast cancer, as it effectively targets the molecular pathways associated with this subtype of cancer.
价 格：￥电议型 号：T40891产 地：中国大陆
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T40040TLR8 agonist 2 hydrochloride；TLR8 agonist 2 hydrochlorideTLR8 agonist 2 hydrochloride
TLR8 agonist 2 hydrochloride is a highly potent and selective agonist for human TLR8, exhibiting an EC50 of 3 nM. However, its activity towards human TLR7 is considerably weaker, with an EC50 of 33.33 μM.
价 格：￥电议型 号：T40040产 地：中国大陆
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T40039TLR8 agonist 2TLR8 agonist 2TLR8 agonist 2
TLR8 agonist 2 is a highly effective and specific compound that activates TLR8, possessing an EC 50 of 3 nM in human TLR8. Notably, TLR8 agonist 2 demonstrates lower activity towards human TLR7, with an EC 50 of 33.33 μM.
价 格：￥电议型 号：T40039产 地：中国大陆
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T39970TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride；TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochlorideT
TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride (compound 9) is a drug-linker conjugate used in antibody-drug conjugates (ADCs) with high efficacy against tumors. It consists of TLR7/8 agonist 4, a potent TLR7/8 agonist, linked to the ADC linker hydroxy-PEG10-acid which can be cleaved.
价 格：￥电议型 号：T39970产 地：中国大陆
