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  • T71231VMY-1-101；化合物 VMY-1-101VMY-1-101

    VMY-1-101 is a synthesized fluorescent CDK inhibitor. VMY-1-101 demonstrates potent CDK inhibitory activity, enhanced induction of G2/M arrest and modest apoptosis as compared to purvalanol B.

    价 格：￥电议型 号：T71231产 地：中国大陆

  • T71230VMY-1-103；化合物 VMY-1-103VMY-1-103

    VMY-1-103 is a potent CDK inhibitor, is also a novel dansylated analog of purvalanol B, was shown to inhibit cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B. VMY-1-103 , but not purvalanol B, significantly decreased the proportion of cells in S phase and increased the proportion of cells in G(2)/M. VMY-1-103 increased the sub G(1) fraction of apoptotic cells, induced PARP and caspase-3 cleavage and increased the levels of the Death

    价 格：￥电议型 号：T71230产 地：中国大陆

  • T7123AMG-47a；化合物AMG-47aAMG-47a

    AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.

    价 格：￥电议型 号：T7123产 地：中国大陆

  • T71123RG 12915；化合物 RG 12915RG 12915

    RG 12915 is a potent, selective 5-HT3 receptor antagonist developed for the treatment of emesis and nausea associated with cancer chemotherapy.

    价 格：￥电议型 号：T71123产 地：中国大陆

  • T70686HJC-0123；化合物 HJC-0123HJC-0123

    Downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER)-negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy.

    价 格：￥电议型 号：T70686产 地：中国大陆

  • T70624S 12340；化合物 S 12340S 12340

    S 12340 is a potent inhibitor of the oxidative modification of low-density lipoprotein.

    价 格：￥电议型 号：T70624产 地：中国大陆

  • T70510CVS-1123；化合物 CVS-1123CVS-1123

    CVS-1123 is a direct thrombin inhibitor, preventing occlusive arterial and venous thrombosis in a canine model of vascular injury.

    价 格：￥电议型 号：T70510产 地：中国大陆

  • T70431TX-1123；化合物 TX-1123TX-1123

    TX-1123 is a potent inhibitor of protein tyrosine kinase (PTK), specifically targeting Src, eEF2-K, PKA, and EGFR-K/PKC. Additionally, it acts as a cyclo-oxygenase (COX) inhibitor, displaying IC50 values of 1.16 μM for COX2 and 15.7 μM for COX1, indicating a higher affinity towards COX2. With low mitochondrial toxicity, TX-1123 is beneficial for cancer research applications.

    价 格：￥电议型 号：T70431产 地：中国大陆

  • T70173NY0123；化合物 NY0123NY0123

    NY0123 is an active EPAC antagonist with low micromolar inhibitory activity.

    价 格：￥电议型 号：T70173产 地：中国大陆

  • T70134L-778123 Dihydrochloride；化合物 L-778123 DihydrochlorideL-778123 Dihydrochloride

    L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.

    价 格：￥电议型 号：T70134产 地：中国大陆

  • T70123N-5984 Hydrochloride；化合物 N-5984 HydrochlorideN-5984 Hydrochloride

    N-5984 Hydrochloride is a beta3-AR agonist.

    价 格：￥电议型 号：T70123产 地：中国大陆

  • T6S2123Ginkgolic Acid；银杏酸Romanicardic acid|||Ginkgolic acid I|||Ginkgolic acid (15:1)|||Ginkgolic acid C15:

    Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.

    价 格：￥电议型 号：T6S2123产 地：中国大陆

  • T69230AZD-1236；化合物 AZD-1236AZD-1236

    AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12 (IC50 = 4.5 and 6.1nM, respectively), with >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other members of the enzyme family. AZD1236 activity is approximately 20 to 50-fold lower at the rat, mouse, and guinea pig orthologues. In acute models of lung injury, AZD1236 inhibited the haemorrhage and inflammation induced by instillation of human MMP-12 into rat lungs by ~80% at 0.81mg/kg, and also abolished

    价 格：￥电议型 号：T69230产 地：中国大陆

  • T6920ON123300；化合物ON123300ON123300

    ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).

    价 格：￥电议型 号：T6920产 地：中国大陆

  • T69123NSC-2488；化合物 NSC-2488NSC-2488

    NSC-2488 is a novel Rho-Kinase-II Inhibitor with Vasodilatory Activity.

    价 格：￥电议型 号：T69123产 地：中国大陆

  • T69045ON012380；化合物 ON012380ON012380

    ON012380 is a non-ATP-competitive Bcr-Abl inhibitor, potently inhibiting imatinib-resistant Bcr-Abl mutants such as T315I.

    价 格：￥电议型 号：T69045产 地：中国大陆

  • T68730AVE1231；化合物 AVE1231AVE1231

    AVE1231 is a TASK-1 channel blocker that inhibits TASK-1 and can be used in the study of atrial fibrillation.

    价 格：￥电议型 号：T68730产 地：中国大陆

  • T68655PAN12314；化合物 PAN12314PAN12314

    PAN12314, also known as Compound 5a, is a 5-HT4R partial agonists that displayed cognition-enhancing properties in animal models. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

    价 格：￥电议型 号：T68655产 地：中国大陆

  • T68615RMI-12330A；化合物 RMI-12330ARMI-12330A

    RMI-12330A is an adenyl cyclase inhibitor.

    价 格：￥电议型 号：T68615产 地：中国大陆

  • T68457GSK812397；化合物 GSK812397GSK812397

    GSK812397 is a potent entry inhibitor of X4-tropic strains of HIV-1, as demonstrated in multiple in vitro cellular assays. GSK812397 is a noncompetitive antagonist of the CXCR4 receptor, with GSK812397 producing a concentration-dependent decrease in both an SDF-1-mediated chemotaxis and intracellular calcium release (IC50s were 0.34+/-0.01 nM and 2.41+/-0.50 nM, respectively). GSK812397 is effective against a broad range of X4- and X4R5-utilizing clinical isolates. The potency and efficacy of GS

    价 格：￥电议型 号：T68457产 地：中国大陆

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