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  • T78949AM841；化合物 AM841AM841

    AM841, a high-affinity electrophilic ligand, covalently interacts with a cysteine residue in helix six, thus activating the CB1 cannabinoid receptor. It diminishes forskolin-stimulated cAMP accumulation and slows gastrointestinal motility [1] [2].

    价 格：￥电议型 号：T78949产 地：中国大陆

  • T78939AChE-IN-31；化合物 AChE-IN-31AChE-IN-31

    AChE-IN-31 (compound 1), a non-competitive acetylcholinesterase (AChE) inhibitor, exhibits potential for Alzheimer´s disease research [1].

    价 格：￥电议型 号：T78939产 地：中国大陆

  • T78922ARD-2051；化合物 ARD-2051ARD-2051

    ARD-2051 is a potent, orally active proteolysis-targeting chimera degrader of the androgen receptor (AR), exhibiting DC50 values of 0.6 nM in degrading AR protein within LNCaP and VCaP prostate cancer cell lines. It holds potential for prostate cancer research applications [1].

    价 格：￥电议型 号：T78922产 地：中国大陆

  • T78838Akt/NF-κB/MAPK-IN-1；化合物 Akt/NF-κB/MAPK-IN-1Akt/NF-κB/MAPK-IN-1

    Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity. This compound exerts anti-inflammatory effects by impeding the Akt/NF-κB and MAPK signaling pathways [1].

    价 格：￥电议型 号：T78838产 地：中国大陆

  • T78763ABCB1-IN-1；化合物 ABCB1-IN-1ABCB1-IN-1

    ABCB1-IN-1 (compound 3) is a potent inhibitor of ABCB1 that promotes cell apoptosis. Featuring 1-benzylimidazole, it exhibits IC50 values of 1.26 μM for Colo205 cells and 2.21 μM for Colo320 cells, respectively [1].

    价 格：￥电议型 号：T78763产 地：中国大陆

  • T78711A011；化合物 A011A011

    A011, a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor, exhibits an IC50 of 1.0 nM and triggers apoptosis as well as G2/M phase cell cycle arrest when combined with CPT-11, displaying notable antitumor activity [1].

    价 格：￥电议型 号：T78711产 地：中国大陆

  • T78686Apoptosis inducer 11；化合物 Apoptosis inducer 11Apoptosis inducer 11

    Apoptosis Inducer 11 (compound 3u) promotes apoptosis via the mitochondrial pathway and elicits a G2/M block alongside a marked reduction in the S phase within non-Hodgkin lymphoma cell lines [1].

    价 格：￥电议型 号：T78686产 地：中国大陆

  • T78531Anti-amyloid agent-1；化合物 Anti-amyloid agent-1Anti-amyloid agent-1

    Anti-amyloid agent-1 is a potent compound that inhibits amyloid aggregation, offering a promising approach for research into the treatment of amyloidosis [1].

    价 格：￥电议型 号：T78531产 地：中国大陆

  • T78434Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA；化合物 Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (

    Mca-(endo-1α-Dap(Dnp))-TNF-α(-5 to +6) amide (human) TFA is a peptide that functions as a fluorescence resonance energy transfer (FRET)-based substrate, with its activity determined by the change in fluorescence intensity following cleavage [1].

    价 格：￥电议型 号：T78434产 地：中国大陆

  • T78284Edrecolomab；化合物 EdrecolomabCO17-1A|||Panorex；CO17-1A|||Panorex

    Edrecolomab (Panorex), a murine monoclonal antibody targeting the 17-1A cell-surface glycoprotein on epithelial tissues and various carcinomas, exhibits anti-tumor properties and is utilized in colorectal carcinoma research [1] [2].

    价 格：￥电议型 号：T78284产 地：中国大陆

  • T78277ATG-031；化合物 ATG-031ATG-031

    ATG-031 is a humanized monoclonal antibody targeting CD24 that promotes macrophage-mediated phagocytosis and induces cancer cell destruction by inhibiting the "don´t eat me" signals associated with various cancer growths. It is applicable for research into hematological malignancies and solid tumors.

    价 格：￥电议型 号：T78277产 地：中国大陆

  • T78204CYP11A1-IN-1；化合物 CYP11A1-IN-1CYP11A1-IN-1

    CYP11A1-IN-1 (compound 30) is a selective inhibitor of the enzyme CYP11A1, displaying an IC50 ranging from 201-2000 nM. It is applicable in the study of steroid receptor-mediated diseases, specifically targeting the androgen receptor for conditions like prostate cancer [1].

    价 格：￥电议型 号：T78204产 地：中国大陆

  • T78134AA74-1；化合物 AA74-1AA74-1

    AA74-1 is a potent, selective APEH inhibitor that significantly enhances T-cell proliferation by inhibiting APEH activity [1].

    价 格：￥电议型 号：T78134产 地：中国大陆

  • T77717AST 7062601；化合物ASTu00A07062601AST070；AST070

    AST 7062601 is a potent Ucp1 inducer that promotes endogenous Ucp1 expression in primary mouse brown adipocytes.AST 7062601 may be useful in the study of obesity.

    价 格：￥电议型 号：T77717产 地：中国大陆

  • T7765E1210；化合物E 1210APX001A|||E 1210；APX001A|||E 1210

    E1210 (APX001A) is broad-spectrum and orally active antifungal

    价 格：￥电议型 号：T7765产 地：中国大陆

  • T77582Anti-inflammatory agent 51；抗炎剂51Anti-inflammatory agent 51

    Anti-inflammatory agent 51 is an amide/sulfonamide derivative with anti-inflammatory and potentially anti-tumor activity and inhibition of NF-κB activation, which can be used to study acute lung injury and ulcerative colitis.

    价 格：￥电议型 号：T77582产 地：中国大陆

  • T77549Nurr1 agonist 2Nurr1激动剂2Nurr1agonist2|||Nurr1 agonist 2

    Nurr1 agonist 2 is a Nurr1 agonist with an EC50 value of 0.07 μM. Nurr1 agonist 2 increases the mRNA expression of the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2). Nurr1 agonist 2 binds to the recombinant Nurr1 ligand-binding domain (LBD) with a Kd of 0.14 μM. Nurr1 agonist 2 can be used to study parkinsonism.

    价 格：￥电议型 号：T77549产 地：中国大陆

  • T77523ALR2-IN-1；化合物ALR2-IN-1ALR2-IN-1

    ALR2-IN-1 is a potent and selective ALR2 inhibitor with an IC50 value of 1.42 μM.ALR2-IN-1 possesses both antiglycemic and antioxidant activities and can be used to study the complications of diabetes.

    价 格：￥电议型 号：T77523产 地：中国大陆

  • T7752(S,R,S)-AHPC-Me；化合物(S,R,S)-AHPC-MeVHL ligand 2|||E3 ligase Ligand 1A；VHL ligand 2|||E3 ligase Ligand

    (S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771. ARV-771 is a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.

    价 格：￥电议型 号：T7752产 地：中国大陆

  • T76910Astegolimab；艾特利单抗RG 6149|||MSTT 1041A；RG 6149|||MSTT 1041A

    Astegolimab (RG 6149) is a humanised IgG2 monoclonal antibody that targets the IL-33 receptor and inhibits IL-33 signalling. Astegolimab is used in the study of chronic obstructive pulmonary disease (COPD) and severe asthma in adults.

    价 格：￥电议型 号：T76910产 地：中国大陆

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