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  • T61687Steroid sulfatase-IN-1；化合物 Steroid sulfatase-IN-1Steroid sulfatase-IN-1

    Steroid sulfatase-IN-1 is a highly potent and orally active inhibitor of the enzyme Steroid sulfatase, with an impressive IC50 value of 1.71 μM. This compound exhibits notable antitumor activity, achieving a TGI (tumor growth inhibition) of 51% in vivo. Therefore, Steroid sulfatase-IN-1 holds great promise in the field of breast cancer research [1].

    价 格：￥电议型 号：T61687产 地：中国大陆

  • T61663SBI-581；化合物 SBI-581SBI-581

    SBI-581 is an orally active, potent selective inhibitor of serine-threonine kinase TAO3, with an IC 50 of 42 nM. It effectively promotes the accumulation of TKS5α at RAB11-positive vesicles and inhibits the formation of invadopodia. Additionally, SBI-581 exhibits reasonable pharmacokinetics in mice when administered via IP injection, demonstrating significant antitumor activity [1].

    价 格：￥电议型 号：T61663产 地：中国大陆

  • T61605SK3 Channel-IN-1；化合物 SK3 Channel-IN-1SK3 Channel-IN-1

    SK3 Channel-IN-1 (compound 7a) is a powerful and selective modulator of the SK3 channel. It demonstrates significant efficacy in inhibiting breast cancer MDA-MB-435 cell migration while maintaining low cytotoxicity in other cell lines. Furthermore, SK3 Channel-IN-1 exhibits the ability to modulate ion channel activity in cancer cells [1].

    价 格：￥电议型 号：T61605产 地：中国大陆

  • T61255SDH-IN-1；化合物 SDH-IN-1SDH-IN-1

    SDH-IN-1 (compound 4i) is a potent succinate dehydrogenase (SDH) inhibitor, exhibiting an IC 50 value of 4.53 μM. This compound displays strong antifungal properties, particularly against S. sclerotiorum, with an EC 50 value of 0.14 mg/L [1].

    价 格：￥电议型 号：T61255产 地：中国大陆

  • T61133SSAO/VAP-1 inhibitor 1；化合物 SSAO/VAP-1 inhibitor 1SSAO/VAP-1 inhibitor 1

    SSAO/VAP-1 Inhibitor 1 is a potent compound aimed at inhibiting SSAO/VAP-1, a protein involved in facilitating the translocation of Glucose Transport 4 (GLUT 4) to the cell membrane in adipocytes, thus playing a crucial role in glucose regulation. Additionally, in endothelial cells, this enzyme is responsible for mediating the adherence and infiltration of leukocytes, contributing to inflammatory responses. Given these mechanisms, SSAO/VAP-1 Inhibitor 1 holds considerable potential for research

    价 格：￥电议型 号：T61133产 地：中国大陆

  • T61112SLF1081851；化合物SLF1081851SLF1081851

    SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM.

    价 格：￥电议型 号：T61112产 地：中国大陆

  • T61033S07-2001；化合物 S07-2001S07-2001

    S07-2001 enhances Doxorubicin against cancer cells activity, which can be used as a chemotherapeutic potentiator for cancer drug resistance. S07-2001 is a potent and selective inhibitor of aldo-keto reductase 1C3 (AKR1C3) with an IC 50 value of 2.08 μM [1].

    价 格：￥电议型 号：T61033产 地：中国大陆

  • T61030STAT3-IN-11；STAT3 抑制剂 11STAT3-IN-11

    STAT3-IN-11 is a selective STAT3 inhibitor with inhibitory effects on phosphorylation of the STAT3pTyr705 site and phosphorylation of Survivin.STAT3-IN-11 promotes apoptosis in cancer cells and is a candidate compound for the treatment of cancer.

    价 格：￥电议型 号：T61030产 地：中国大陆

  • T60946SLK/STK10-IN-1；化合物 SLK/STK10-IN-1SLK/STK10-IN-1

    SLK/STK10-IN-1 is a potent and selective SLK and STK10 inhibitor with nanomolar effect.

    价 格：￥电议型 号：T60946产 地：中国大陆

  • T60861SARS-CoV-2 nsp3-IN-1；化合物 SARS-CoV-2 nsp3-IN-1SARS-CoV-2 nsp3-IN-1

    SARS-CoV-2 nsp3-IN-1 (Compound 15c) shows significant selectivity for coronavirus macrodomains, especially SARS-CoV-2 Mac1. SARS-CoV-2 nsp3-IN-1 can inhibit Mac1 ADP-ribosylhydrolase activity that is an inhibitor of Mac1 (IC50 = 6.1 μM) [1].

    价 格：￥电议型 号：T60861产 地：中国大陆

  • T60839SLMP53-1；化合物 SLMP53-1SLMP53-1

    SLMP53-1 is a p53 activator with anti-tumor activity, inhibits wt and mutp53, activates reprogramming of glucose metabolism in xenografted human tumor tissues, and interferes with angiogenesis and migration. SLMP53-1 inhibits tumor cell growth and can be used to study human rectal cancer.

    价 格：￥电议型 号：T60839产 地：中国大陆

  • T60686SARS-CoV-2 Mpro-IN-1；化合物 SARS-CoV-2 Mpro-IN-1SARS-CoV-2 Mpro-IN-1

    SARS-CoV-2 Mpro-IN-1 (compound 16b-3) is a potent, selective and irreversible SARS-CoV-2 main protease (Mpro) inhibitor (IC 50 = 116 nM) [1].

    价 格：￥电议型 号：T60686产 地：中国大陆

  • T60644SJ000063181；化合物SJ000063181SJ000063181

    SJ000063181 is a potent activator of BMP signaling, exhibiting an EC50 of ≤1 μM. It serves as a valuable chemical probe for BMP signaling analysis, owing to its ability to penetrate zebrafish embryos.

    价 格：￥电议型 号：T60644产 地：中国大陆

  • T60639SLEC-11；化合物 SLEC-11SLEC-11

    SLEC-11 emerged as a synthetic lethal(SL) lead in E-cadherin-deficient cells which has potential for the treatment of gastric cancer.

    价 格：￥电议型 号：T60639产 地：中国大陆

  • T60554Schnurri-3 inhibitor-1；化合物Schnurri-3抑制剂-1Schnurri-3 inhibitor-1

    Schnurri-3 inhibitor-1 is a potent inhibitor of schnurri-3, an essential regulator of adult bone formation. Schnurri-3 inhibitor-1 can inhibit Shn3 with EF1alpha promoter in Shn3FFL (osteoblast cell line, AC50= 2.09 μM). Schnurri-3 inhibitor-1 has research value in osteoporosis.

    价 格：￥电议型 号：T60554产 地：中国大陆

  • T60150(1S,2R)-Alicapistat；化合物T60150(1S,2R)-Alicapistat

    (1S,2R)-Alicapistat ((1S,2R)-ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, with promising implications for Alzheimer´s disease (AD) therapy [1]. This compound effectively addresses the metabolic liability associated with carbonyl reduction, while demonstrating potent inhibition of calpain 1 with an IC50 value of 395 nM [2].

    价 格：￥电议型 号：T60150产 地：中国大陆

  • T60077SCP1-IN-1；化合物SCP1-IN-1SCP1-IN-1

    SCP1-IN-1 (compound SH T-62) is a potent and selective covalent inhibitor against SCP1. SCP1-IN-1 promotes REST degradation and reduces transcriptional activity. In some glioblastoma cells, the high level of REST protein drives tumor growth. SCP1-IN-1 has the potential for the research of glioblastoma whose growth is driven by REST transcription activity [1].

    价 格：￥电议型 号：T60077产 地：中国大陆

  • T60029SOS1-IN-11；化合物 SOS1-IN-11SOS1-IN-11

    SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).

    价 格：￥电议型 号：T60029产 地：中国大陆

  • T5831Selective PI3Kδ Inhibitor 1；化合物Selective PI3Kδ Inhibitor 1Selective PI3Kδ Inhibitor 1

    Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).

    价 格：￥电议型 号：T5831产 地：中国大陆

  • T5194SPHINX31；化合物SPHINX31SPHINX31

    SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50: 5.9 nM).

    价 格：￥电议型 号：T5194产 地：中国大陆

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