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T6864Ixabepilone；伊沙匹隆BMS 247550|||Ixempra|||Azaepothilone B|||BMS 247550-1；BMS 247550|||Ixempra|||Azaepot
Ixabepilone (Azaepothilone B) is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis.
价 格：￥电议型 号：T6864产 地：中国大陆
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T68266BMS-751324；化合物 BMS-751324BMS-751324
BMS-751324, a p38α MAPK inhibitor, features a carbamyl-methyl linkage precursor with esters and phosphate functional groups from hydroxyphenylacetic acid (HPA). It effectively reduces foot swelling and suppresses LPS-induced TNFα production in an arthritic rat model.
价 格：￥电议型 号：T68266产 地：中国大陆
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T68227BMS-214662 HCl；化合物 BMS-214662 HClBMS-214662 HCl
BMS-214662 is a Farnesyltransferase inhibitor , is also a nonsedating benzodiazepine derivative with potential antineoplastic activity. BMS-214662 inhibits the enzyme farnesyltransferase and the post-translational farnesylation of number of proteins involved in signal transduction, which may result in the inhibition of Ras function and apoptosis in susceptible tumor cells. This agent may reverse the malignant phenotype of H-Ras-transformed cells and has been shown to be active against tumor cell
价 格：￥电议型 号：T68227产 地：中国大陆
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T68170Xl-281；化合物 Xl-281BMS-908662；BMS-908662
Xl-281 (BMS-908662) is a BRAF inhibitor with anti-tumor activity for the study of colorectal cancer and melanoma.
价 格：￥电议型 号：T68170产 地：中国大陆
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T6789BMS582949；化合物BMS582949BMS 582949|||PS540446|||BMS-582949；BMS 582949|||PS540446|||BMS-582949
BMS-582949 is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13 nM, inhibiting both p38 kinase activity and activation of p38.
价 格：￥电议型 号：T6789产 地：中国大陆
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T67818BMS-641988；化合物BMS-641988BMS-641988
BMS-641988 is a novel nonsteroidal androgen receptor antagonist for the treatment of prostate cancer.
价 格：￥电议型 号：T67818产 地：中国大陆
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T67791BMS-903452；化合物BMS-903452BMS-903452
BMS-903452 is a potent and selective GPR119 agonist with EC50 of 14 nM. BMS-903452 is indicated for the treatment of acute and chronic rodent diabetes. GPR119 was mainly expressed in pancreatic b cells and gastrointestinal endocrine cells. GPR119 had no significant inhibitory effect on 9 different cytochrome P450 enzymes (IC50 > 40 μM), did not activate PXR (EC50>50 μM), and was not toxic to liver (HEPG2) cell lines.
价 格：￥电议型 号：T67791产 地：中国大陆
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T6735XL413 hydrochloride；化合物XL413 hydrochlorideBMS-863233 Hydrochloride|||XL413|||BMS-863233；BMS-863233 H
XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 hydrochloride also exhibits potent effect with IC 50 s of 215, 42 nM on CK2, PIM1, respectively, and an EC 50 of 118 nM on pMCM.
价 格：￥电议型 号：T6735产 地：中国大陆
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T6420BMS-707035化合物BMS707035N-[(4-氟苯基)甲基1,6-二氢-5-羟基-1-甲基-6-氧代-2-(四氢-1,1-二氧-2H-1,2-噻嗪-2-基)-4-嘧啶甲酰胺
BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.
价 格：￥电议型 号：T6420产 地：中国大陆
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T6419BMS-536924；胰岛素样生长因子-1 受体拮抗剂HY-10262|||BMS 536924|||CS-0117；HY-10262|||胰岛素样生长因子-1 受体拮抗剂|||BMS 536924|
BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.
价 格：￥电议型 号：T6419产 地：中国大陆
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T6418BMS-378806；化合物BMS378806BMS378806|||BMS-806；BMS378806|||BMS-806|||1-[(2R)-4-苯甲酰基-2-甲基-1-哌嗪基]-2-(4-甲氧基
BMS-378806 (BMS-806) selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus.
价 格：￥电议型 号：T6418产 地：中国大陆
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T64046BMS-820132；化合物 BMS-820132BMS-820132
BMS-820132 is a glucokinase activator (AC50: 29 nM).
价 格：￥电议型 号：T64046产 地：中国大陆
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T63966BMS-986141；化合物BMS-986141UDM-003183；UDM-003183
BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614 exhibits significant antithrombotic effects.
价 格：￥电议型 号：T63966产 地：中国大陆
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T63439BMS-986020 sodium；化合物 BMS-986020 sodiumBMS-986020 sodium
BMS-986020 sodium is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist that inhibits bile acids and phospholipid transport proteins, and inhibits BSEP (IC50: 4.8 μM), MRP4 (IC50: 6.2 μM) and MDR3 (IC50: 7.5 μM). BMS-986020 sodium showed potential for the study of idiopathic pulmonary fibrosis (IPF).
价 格：￥电议型 号：T63439产 地：中国大陆
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T63355BMS-309403 sodium；化合物 BMS-309403 sodiumBMS-309403 sodium
BMS-309403 sodium is a potent, orally active, selective inhibitor of the adipocyte fatty acid binding protein (FABP4, aP2), demonstrating inhibitory constants (K i ) of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. It operates by competitively binding to the fatty-acid-binding pocket of the protein, thereby impeding the attachment of endogenous fatty acids. This compound has been shown to enhance endothelial function both in apolipoprotein E-deficient mice and cultured human end
价 格：￥电议型 号：T63355产 地：中国大陆
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T6326BMS-345541；化合物BMS345541BMS-345541 free base|||IKK Inhibitor III|||BMS345541；BMS-345541 free base|||I
BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
价 格：￥电议型 号：T6326产 地：中国大陆
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T63246BMS-566419；化合物 BMS-566419BMS-566419
BMS-566419 is an acridinone-based inhibitor of inosine 5´-monophosphate dehydrogenase (IMPDH), a key enzyme for the de novo synthesis of guanosine nucleotides. BMS-566419 has clinical utility in the study of graft rejection.
价 格：￥电议型 号：T63246产 地：中国大陆
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T6297Alvespimycin hydrochloride；阿螺旋霉素盐酸盐BMS 826476|||NSC 707545|||KOS-1022|||17-DMAG hydrochloride|||Alve
Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.
价 格：￥电议型 号：T6297产 地：中国大陆
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T6267Lomitapide；洛美他派AEGR-733|||BMS-201038；AEGR-733|||洛美他派|||BMS-201038
Lomitapide (AEGR-733) is a small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring triglycerides onto apolipoprotein B (apo-B) in the assembly of very-low-density lipoprotein.
价 格：￥电议型 号：T6267产 地：中国大陆
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T62552Ozanimod hydrochloride；Ozanimod 盐酸盐BMS-986374 hydrochloride|||RPC-1063 hydrochloride；BMS-986374 hydr
Ozanimod hydrochloride (RPC-1063 hydrochloride) is an orally available, selective and potent sphingosine 1-phosphate (S1P) receptor modulator that shows high affinity for S1P1 and S1P5.Ozanimod has potential anticancer activity and can be used in the study of multiple sclerosis (MS), ulcerative multiple sclerosis (UMS), and other diseases. (MS), ulcerative colitis, coronavirus infections and myelodysplasia.
价 格：￥电议型 号：T62552产 地：中国大陆
