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  • T5677SAR125884 hydrochlorid (1116743-46-4(free base))；化合物SAR125884 hydrochloridSAR125884 hydrochlorid (11

    SAR125844 is a potent and selective MET kinase inhibitor with a favorable preclinical toxicity profile,(IC50=4.2 nM).

    价 格：￥电议型 号：T5677产 地：中国大陆

  • T5116Iprodione；异菌脲Iprodione

    Iprodione is a fungicide. Iprodione is also used in cannabis testing kits as a component of pesticide mixes.

    价 格：￥电议型 号：T5116产 地：中国大陆

  • T41169P21d hydrochloride；P21d hydrochlorideP21d hydrochloride

    P21d hydrochloride is a potent and selective breast tumor Ki nase (Brk) inhibitor (IC50 = 30 nM). Exhibits >650-fold selectively for Brk over Aurora B Ki nase and Lck. Downregulates SNAIL protein, restores E-cadherin expression and suppresses migration in breast cancer cells. Also activein vivoand orally bioavailable.

    价 格：￥电议型 号：T41169产 地：中国大陆

  • T41168SJF 0661；SJF 0661SJF 0661

    SJF 0661 is the negative control for SJF 0628. Binds BRAF without inducing degradation.

    价 格：￥电议型 号：T41168产 地：中国大陆

  • T41167CG 858-Neg；CG 858-NegCG 858-Neg

    Negative control for CG 858

    价 格：￥电议型 号：T41167产 地：中国大陆

  • T41166NVS PAK1 C；NVS PAK1 CNVS PAK1 C

    NVS PAK1 C is a negative control of NVS PAK1 1, a potent and selective PAK1 inhibitor.

    价 格：￥电议型 号：T41166产 地：中国大陆

  • T41165ETP 45835 dihydrochloride；ETP 45835 dihydrochlorideETP 45835 dihydrochloride

    ETP 45835 dihydrochloride is a Mnk2 and Mnk1 inhibitor (IC50 values are 575 and 646 nM respectively). Exhibits selectivity against a panel of 24 protein Ki nases, including those upstream of Mnk1/2.

    价 格：￥电议型 号：T41165产 地：中国大陆

  • T41164FC 11；FC 11FC 11

    FC 11 is a highly potent focal adhesion Ki nase (FAK) PROTAC?Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide. The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells.

    价 格：￥电议型 号：T41164产 地：中国大陆

  • T41163ZNL 02-096；化合物ZNL 02-096Pomalidomide-C3-adavosertib；Pomalidomide-C3-adavosertib

    ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL 02-096 induces degradation of Wee1 and accumulation of DNA damage in MOLT-4 cells in vitro, In vitro in MOLT-4 cells, ZNL 02-096 induced Wee1 degradation, accumulation of DNA damage, cell cycle arrest in G2/M phase and apoptosis.ZNL 02-096 showed anti-proliferative effects in 300

    价 格：￥电议型 号：T41163产 地：中国大陆

  • T41162ZLN 024 hydrochloride；化合物ZLN 024 hydrochlorideZLN 024 hydrochloride

    ZLN 024 hydrochloride is an AMPK allosteric activator and stimulates the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).

    价 格：￥电议型 号：T41162产 地：中国大陆

  • T41160Lalistat 2；化合物Lalistat 2Lalistat 2

    Lalistat 2 is a selective inhibitor of lysosomal acid lipase with IC50 of 152 nM and exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).

    价 格：￥电议型 号：T41160产 地：中国大陆

  • T4116S-Adenosyl-DL-Methionine；S-腺苷蛋氨酸Ademetionine|||S-ADENOSYL-L-METHIONINE；Ademetionine|||S-腺苷蛋氨酸|||S-AD

    S-Adenosyl-DL-Methionine (Ademetionine) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases. SAM reportedly ameliorates depression, pain associated with osteoarthritis and fibromyalgia, and liver toxicity.

    价 格：￥电议型 号：T4116产 地：中国大陆

  • T41116FV-100；化合物FV-100Valnivudine HCl；Valnivudine HCl

    FV-100 (Valnivudine HCl) is a potent, selective and orally active anti-vaxx-zoster agent.FV-100 is the API for CF-1743.FV-100 exhibits very low toxicity in vivo.FV-100 is a potent, selective and orally active anti-vaxx-zoster agent.FV-100 is the API for CF-1743.FV-100 exhibits very low toxicity in vivo.

    价 格：￥电议型 号：T41116产 地：中国大陆

  • T41061Histone H3 (116-136), C116-136；Histone H3 (116-136), C116-136Histone H3 (116-136), C116-136；Histone

    Histone H3 (116-136), C116-136 is a peptide consisting of amino acids 116 to 136, which spans the C-terminus of histone H3.

    价 格：￥电议型 号：T41061产 地：中国大陆

  • T40116IL-17A inhibitor 2；IL-17A inhibitor 2IL-17A inhibitor 2

    IL-17A inhibitor 2 is an IL-17A inhibitor for treating psoriasis, rheumatoid arthritis, and multiple sclerosis.

    价 格：￥电议型 号：T40116产 地：中国大陆

  • T40111LBMS-1166-N-piperidine-CO-N-piperazine dihydrochloride；化合物T40111LBMS-1166-N-piperidine-CO-N-piperazin

    BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride is a resorcinol di-Ph ether scaffold-based programmed cell death-1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitor that inhibits the PD-1/PD-L1 interaction with an IC50 of 39.2 nM.BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride contains the target protein PD-1/PD-L1 ligand and PROTAC linker.BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used to synthesize PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydro

    价 格：￥电议型 号：T40111L产 地：中国大陆

  • T40111BMS-1166-N-piperidine-CO-N-piperazine；BMS-1166-N-piperidine-CO-N-piperazineBMS-1166-N-piperidine-CO-

    BMS-1166-N-piperidine-CO-N-piperazine is a chemical compound that contains a PD-1/PD-L1 immune checkpoint ligand and a PROTAC linker. It can be utilized in the synthesis of PROTAC PD-1/PD-L1 degrader-1, which effectively inhibits the PD-1/PD-L1 interaction, demonstrating an IC50 value of 39.2 nM.

    价 格：￥电议型 号：T40111产 地：中国大陆

  • T40110BMS-1166-N-piperidine-COOH；BMS-1166-N-piperidine-COOHBMS-1166-N-piperidine-COOH

    BMS-1166-N-piperidine-COOH is a chemical compound that functions as the BMS-1166-based moiety. It binds to the E3 ligase ligand through a linker, leading to the formation of PROTAC PD-1/PD-L1 degrader-1, which facilitates the degradation of PD-1/PD-L1. BMS-1166 demonstrates potent inhibition of PD-1/PD-L1 interaction, with an IC 50 of 1.4 nM. By antagonizing the inhibitory effect of the PD-1/PD-L1 immune checkpoint on T cell activation, BMS-1166 promotes T cell activation.

    价 格：￥电议型 号：T40110产 地：中国大陆

  • T39800S2116；S2116S2116

    S2116 is a powerful inhibitor of lysine-specific demethylase 1 (LSD1), and it is a derivative of N-alkylated tranylcypromine (TCP). S2116 exhibits its inhibitory effects by increasing H3K9 methylation and inducing reciprocal H3K27 deacetylation at super-enhancer regions. In TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells, S2116 triggers apoptosis by repressing the transcription of NOTCH3 and TAL1 genes. Furthermore, S2116 demonstrates significant growth retardation of T-ALL cells

    价 格：￥电议型 号：T39800产 地：中国大陆

  • T39116Ruzinurad；RuzinuradRuzinurad

    Ruzinurad (WO2020088641, compound I) is a potent URAT1 inhibitor, exhibiting high selectivity. This compound shows great promise for investigating hyperuricemia.

    价 格：￥电议型 号：T39116产 地：中国大陆

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