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  • T70164LASSBio-1829 HCl；化合物 LASSBio-1829 HClLASSBio-1829 HCl

    LASSBio-1829 HCl is an orally active IKK2 inhibitor.

    价 格：￥电议型 号：T70164产 地：中国大陆

  • T70074SB1-F-21；化合物 SB1-F-21SB1-F-21

    SB1-F-21 is an UCHL1 inhibitor.

    价 格：￥电议型 号：T70074产 地：中国大陆

  • T69947SB1-F-78；化合物 SB1-F-78SB1-F-78

    SB1-F-78 is an USP30 inhibitor.

    价 格：￥电议型 号：T69947产 地：中国大陆

  • T69888SB02024；化合物 SB02024SB02024

    SB02024 is a VPS34 inhibitor. SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist. SB02024 blocked autophagy in vitro and reduced xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7, in vivo. Vps34 inhibitor significantly potentiated cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro in monolayer cultures and when grown as multicellular spheroids. Our data suggests that inhibition of autophagy significantly improves sensitivity

    价 格：￥电议型 号：T69888产 地：中国大陆

  • T69860PSB-15160；化合物PSB-15160PSB-15160

    PSB-15160 is a compound that inhibits the growth of MCF7 (breast), NCI-H460 (lung) and SF-268 (NCS) cells in the treatment of estrogen-dependent tumours.

    价 格：￥电议型 号：T69860产 地：中国大陆

  • T69824PSB-17365；化合物 PSB-17365PSB-17365

    PSB-17365 is a potent GPR84 agonist. PSB-17365 exhibits EC50 values vs. GPR84 of 2.5nM in a cAMP accumulation assay, and 100nM in a β-arrestin 2 recruitment assay. No direct binding affinities are provided. PSB-17365 is selective for GPR84 compared to other free fatty acid receptors (FFAR1 and FFAR4). GPR84, a Gi protein-coupled receptor that is activated by medium-chain (hydroxy)fatty acids, appears to play an important role in inflammation, immunity, and cancer.

    价 格：￥电议型 号：T69824产 地：中国大陆

  • T69815SB-284851-BT；化合物 SB-284851-BTSB-284851-BT

    SB-284851-BT is a chemical compound that serves as an inhibitor of BRD4, p38α, and BRDT, exhibiting varying degrees of affinity and inhibition for each. Specifically, it inhibits BRD4-BD1 with an IC50 value of 1.7 ?M, p38α with a Kd of 0.47 nM, BRDT (1) with an IC50 value of 18 ?M, and BRD4 (1) with an IC50 value of 3.7 ?M. By targeting p38α, SB-284851-BT effectively reduces IL-8 production and, through inhibiting BRD4, down-regulates both the c-Myc and NF-κB gene pathways, crucial in cancer pat

    价 格：￥电议型 号：T69815产 地：中国大陆

  • T6977SB-366791；化合物SB366791SB366791；SB366791

    SB-366791 is a new and selective cinnamide TRPV1 antagonist.

    价 格：￥电议型 号：T6977产 地：中国大陆

  • T6976SB 239063；化合物SB239063SB239063；SB239063

    SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.

    价 格：￥电议型 号：T6976产 地：中国大陆

  • T69675PSB-1901 free base；化合物 PSB-1901 free basePSB-1901 free base

    PSB-1901 is a potent A2B Adenosine Receptor Antagonist with Picomolar Potency (Ki 0.0835 nM, KB 0.0598 nM, human A2BAR) with >10 000-fold selectivity versus all other AR subtypes. PSB-1901 was similarly potent and selective at the mouse A2BAR, making it a promising tool for preclinical studies.

    价 格：￥电议型 号：T69675产 地：中国大陆

  • T69612PSB-KD477；化合物 PSB-KD477PSB-KD477

    PSB-KD477 is an Agonist of the Cannabinoid-Activated Orphan G-Protein-Coupled Receptor GPR18. PSB-KD477 displayed significantly higher potency and efficacy than THC, determined in a GPR18-dependent β-arrestin recruitment assay, and were found to be selective versus the CB-sensitive receptors CB1, CB2, and GPR55. Structure-activity relationships were steep, and indole substitution was crucial for biological activity. These first selective agonists, which are structurally distinct from the lipidic

    价 格：￥电议型 号：T69612产 地：中国大陆

  • T68908PSB-10211；化合物 PSB-10211PSB-10211

    PSB-10211 is a potent competitive antagonist and positive modulator of the P2X2 receptor.

    价 格：￥电议型 号：T68908产 地：中国大陆

  • T68805PSB-1584；化合物 PSB-1584PSB-1584

    PSB-1584 is a Potent Agonist of the Orphan G Protein-Coupled Receptor 84 (GPR84). GPR84, a Gi protein-coupled receptor that is activated by medium-chain (hydroxy)fatty acids, appears to play an important role in inflammation, immunity, and cancer.

    价 格：￥电议型 号：T68805产 地：中国大陆

  • T68470ASB-16165；化合物 ASB-16165ASB-16165

    ASB-16165 is a phosphodiesterase 7A inhibitor that impairs proliferation of keratinocytes in vitro and in vivo. Inhibitors of PDE7A including ASB16165 might be useful for the treatment of psoriasis.

    价 格：￥电议型 号：T68470产 地：中国大陆

  • T68296SB1578；化合物 SB1578SB1578

    SB1578, also known as ONX-0805, is a novel, orally bioavailable JAK2 inhibitor with specificity for JAK2 within the JAK family and also potent activity against FLT3 and c-Fms. SB1578 blocks the activation of these kinases and their downstream signaling in pertinent cells, leading to inhibition of pathological cellular responses. The biochemical and cellular activities of SB1578 translate into its high efficacy in two rodent models of arthritis.

    价 格：￥电议型 号：T68296产 地：中国大陆

  • T6825Eltrombopag Olamine；艾曲波帕乙醇胺盐Promacta Olamine|||Revolade|||Eltrombopag diethanolamine salt|||SB497115

    Eltrombopag Olamine (Eltrombopag diethanolamine salt) is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an in

    价 格：￥电议型 号：T6825产 地：中国大陆

  • T68135L1(Rac)-Sabcomeline；(Rac)-沙可美林(Rac)-SB-202026；(Rac)-SB-202026

    (Rac)-Sabcomeline ((Rac)-SB-202026) is an M1/M4 muscarinic agonist used in the study of neurologic disorders such as schizophrenia.

    价 格：￥电议型 号：T68135L1产 地：中国大陆

  • T68135sabcomeline；化合物 sabcomelineSB-202026|||SB-202026 ; Memric|||Memric；SB-202026|||SB-202026 ; Memric|

    Sabcomeline, a potent and functionally selective partial agonist at muscarinic M1 receptors, enhances cognition and is utilized in Alzheimer´s disease research [1] [2].

    价 格：￥电议型 号：T68135产 地：中国大陆

  • T6791BPTES；化合物BPTESBPTES

    BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.

    价 格：￥电议型 号：T6791产 地：中国大陆

  • T67787Adafosbuvir PM；化合物Adafosbuvir PMAL-335 PM；AL-335 PM

    Adafosbuvir PM (AL-335 PM) is a small molecule NS5B inhibitor that can be used to study chronic hepatitis C.

    价 格：￥电议型 号：T67787产 地：中国大陆

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