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T36991Monascuspiloin;MonascuspiloinMonascuspiloin
Monascuspiloin is a fungal metabolite that has been found inM. pilosusM93-fermented rice.1It induces endoplasmic reticulum stress and autophagy in PC3 prostate cancer cells. Monascuspiloin (15-45 μM) decreases viability of PC3 cells and has an additive effect on the reduction in viability of PC3 cells induced by irradiation when used at a concentration of 25 μM. It induces intratumor apoptosis and autophagy and reduces tumor growth in a PC3 mouse xenograft model when administered at doses of 40
价 格:¥电议型 号:T36991产 地:中国大陆
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T3678Entrectinib;恩曲替尼RXDX-101|||NMS-E628;RXDX-101|||恩曲替尼|||NMS-E628
Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectinib blocks proliferation of ALK-dependent cell lines, including those with C1156Y or L1196M resistance mutations, and inhibits ALK‐dependent signaling. It has been shown to inhibit the growth of a non-small cell lung Y cell line bearing an EML4-ALK rearrangement. In mice bearing va
价 格:¥电议型 号:T3678产 地:中国大陆
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T36360Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2;Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2
Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9. Upon cleavage by MMP-1 or MMP-9, N-methylanthranilic acid (Nma) is unquenched and its fluorescence can be used to quantify MMP activity. Nma displays excitation/emission spectra of 340/440 nm, respectively.
价 格:¥电议型 号:T36360产 地:中国大陆
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T36207Methylspinazarin;MethylspinazarinMethylspinazarin
Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg/ml).1 It is selective for COMT over tyrosine hydroxylase, DOPA decarboxylase, and dopamine-β-hydroxylase at 100 μg/ml. Methylspinazarin decreases blood pressure in spontaneously hypertensive rats when administered at a dose of 50 mg/kg.
价 格:¥电议型 号:T36207产 地:中国大陆
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T35626AMP-Deoxynojirimycin;化合物 AMP-DeoxynojirimycinAMP-DNM;AMP-DNM
AMP-Deoxynojirimycin (AMP-DNM) is a potent inhibitor of ceramide glucosyltransferase and GCase 2.AMP-Deoxynojirimycin is a potent inhibitor of GlcCer biosynthesis and is used in the study of Parkinson´s and diabetes.
价 格:¥电议型 号:T35626产 地:中国大陆
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T35616Migrastatin;MigrastatinMigrastatin
Migrastatin is a bacterial metabolite that has been found inStreptomyceswith antimuscarinic and anticancer activities.1,2It binds to M1-5muscarinic acetylcholine receptors (Kis = >200, 200, 31, 43, and >200 μM, respectively) and inhibits calcium mobilization induced by carbamoylcholine in SK-N-SH cells (IC50= 28 μM), as well as in primary rat bladder smooth muscle cells.1Migrastatin inhibits the migration of EC17 esophageal cancer cells in a wound healing assay (IC50= 10 μg/ml) and 4T1 mouse mam
价 格:¥电议型 号:T35616产 地:中国大陆
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T34624Setileuton;化合物SetileutonMK0633|||MK 0633|||MK-0633;MK0633|||MK 0633|||MK-0633
Setileuton (MK0633) is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis.
价 格:¥电议型 号:T34624产 地:中国大陆
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T33701NM-3;NM-3(异香豆素)NM-3|||isocoumarin|||NM 3|||Isocoumarin NM-3|||NM3;NM-3|||isocoumarin|||NM 3|||Isocou
NM-3 is an orally available anti-angiogenic inhibitor with anti-tumour activity.NM-3 is used as a radiation modulator in vitro and in vivo.NM-3 inhibits vascular endothelial growth factor (VEGF), thereby inhibiting the proliferation of endothelial cells. This inhibits the proliferation of endothelial cells. NM-3 is associated with a mechanism of apoptosis induction by reactive oxygen species.
价 格:¥电议型 号:T33701产 地:中国大陆
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T33513MSBN;化合物MSBNMSBN
MSBN is a highly selective fluorescent probe for mercaptans that can selectively image mercaptans in living cells and specifically label protein mercaptans by switching on the signal to identify various reversible protein mercaptans modifications.
价 格:¥电议型 号:T33513产 地:中国大陆
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T33463Mnm5s2U;化合物 T33463mnm-5s2U|||mnm 5s2U;mnm-5s2U|||mnm 5s2U
Mnm5s2U is a hypermodified nucleoside.
价 格:¥电议型 号:T33463产 地:中国大陆
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T33296Merodantoin;化合物MerodantoinMerodantoin
Merodantoin is an apoptosis inducer and triggers cell apoptosis associated with ROS-dependent autophagy. Merodantoin targets cancer cells expressing KRAS mutations involved in Akt-dependent ROS production.
价 格:¥电议型 号:T33296产 地:中国大陆
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T32451L 644257;化合物 T32451L-644257|||6-Coham|||Nmanchol|||L644257;L-644257|||6-Coham|||Nmanchol|||L644257
L 644257 is a synthetic glycolipid for study liposomes in vivo.
价 格:¥电议型 号:T32451产 地:中国大陆
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T31594EA-230;化合物 T31594EA 230|||NMPF-46|||NMPF46|||NMPF 46;EA 230|||NMPF-46|||NMPF46|||NMPF 46
Ea-230 is an immunomodulator that may be used in the treatment of renal failure.
价 格:¥电议型 号:T31594产 地:中国大陆
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T3134(Z)-Mirin;化合物MirinMirin;Mirin
(Z)-Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity.
价 格:¥电议型 号:T3134产 地:中国大陆
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T2S0663Humantenmine;胡蔓藤碱甲Humantenmine
1. Humantenmine is a toxic compound isolated from Gelsemium elegans Benth . 2. Humantenmine and koumine may inhibit several CYP450 enzyme activities.
价 格:¥电议型 号:T2S0663产 地:中国大陆
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T29095Valtorcitabine dihydrochloride;化合物 T29095LDC-300|||NM 147 monoVal-L-dC|||LDC300|||NM-147|||LDC 300||
Valtorcitabine dihydrochloride, a DNA polymerase inhibitor, is used potentially for the treatment of HBV infection.
价 格:¥电议型 号:T29095产 地:中国大陆
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T29094Valopicitabine dihydrochloride;化合物 T29094NMC283|||Valopicitabine HCl|||NM-283|||Valopicitabine|||NMC
Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.
价 格:¥电议型 号:T29094产 地:中国大陆
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T28296Parogrelil hydrochloride;化合物 T28296INDI-702|||NM-702|||NT-702|||NM702|||INDI702;INDI-702|||NM-702|||
Parogrelil is a phosphodiesterase (PDE3/PDE5A) inhibitor potentially for the treatment of intermittent. Parogrelil suppress the asthmatic response in guinea pigs, with both bronchodilating and anti-inflammatory effects. Parogrelil improves reduced walking distance and lowered hindlimb plantar surface temperature in a rat experimental intermittent claudication model.
价 格:¥电议型 号:T28296产 地:中国大陆
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T28179NMK-TD-100;化合物 T28179NMK-TD 100|||NMK-TD100;NMK-TD 100|||NMK-TD100
NMK-TD-100 is a microtubule modulating agent with anti-proliferative activity by disrupting microtubule functions through tubulin binding. NMK-TD-100 blocks mitosis and induces apoptosis in HeLa cells by binding to tubulin. Polymerization of tissue purified tubulin into microtubules was inhibited by NMK-TD-100 with an IC50 value of 17.5±0.35 ?M.
价 格:¥电议型 号:T28179产 地:中国大陆