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T17905(S,R,S)-AHPC-PEG1-OTs；化合物 T17905VH032-PEG1-OTs|||VHL Ligand-Linker Conjugates 2|||E3 ligase Ligand-L
(S,R,S)-AHPC-PEG1-OTs is a chemically synthesized conjugate, functioning as an ligase ligand-linker for E3 ligase. It incorporates the VHL ligand derived from (S,R,S)-AHPC and a 1-unit PEG linker. This synthesized compound is commonly employed in PROTAC technology.
价 格：￥电议型 号：T17905产 地：中国大陆
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T17904Pomalidomide-PEG1-C2-N3；化合物 T17904E3 ligase Ligand-Linker Conjugates 50|||Cereblon Ligand-Linker Con
Pomalidomide-PEG1-C2-N3 is a compound that has been synthesized as a conjugate of an E3 ligase ligand-linker. This compound incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, which are commonly used in PROTAC technology. Utilizing Pomalidomide-PEG1-C2-N3, it is possible to design a selective CDK6 PROTAC degrader known as CP-10. CP-10 effectively induces the degradation of CDK6, displaying a DC50 value of 2.1 nM[1].
价 格：￥电议型 号：T17904产 地：中国大陆
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T17903Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH；化合物 T17903E3 ligase Ligand-Linker Conjugates 49|||Cereblo
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a chemically synthesized compound, designed as an E3 ligase ligand-linker conjugate, integrating the cereblon ligand derived from Pomalidomide and a linker employed in PROTAC technology. This compound serves to facilitate targeted protein degradation through the modulation of E3 ligase activity, enabling the selective elimination of specific proteins of interest.
价 格：￥电议型 号：T17903产 地：中国大陆
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T17902Nutlin-C1-amido-PEG4-C2-N3；化合物 T17902E3 ligase Ligand-Linker Conjugates 48|||MDM2 Ligand-Linker Conj
Nutlin-C1-amido-PEG4-C2-N3 is a novel compound that functions as a ligand-linker conjugate for the E3 ligase. It is a synthesized molecule incorporating the MDM2 ligand derived from Nutlin 3, and a 4-unit PEG linker. This compound is specifically designed for utilization in PROTAC technology.
价 格：￥电议型 号：T17902产 地：中国大陆
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T17901cIAP1 Ligand-Linker Conjugates 10；化合物 T17901E3 ligase Ligand-Linker Conjugates 47；E3 ligase Ligand-L
cIAP1 Ligand-Linker Conjugates 10 comprise of an IAP ligand and a PROTAC linker, which facilitates the design of SNIPERs. These conjugates incorporate an IAP ligand that interacts with the E3 ubiquitin ligase, and a PROTAC linker. SNIPERs can be developed using cIAP1 Ligand-Linker Conjugates 10.
价 格：￥电议型 号：T17901产 地：中国大陆
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T17900cIAP1 Ligand-Linker Conjugates 8；化合物 T17900E3 ligase Ligand-Linker Conjugates 46；E3 ligase Ligand-Li
cIAP1 Ligand-Linker Conjugates 8 comprises an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is specifically utilized for the purpose of SNIPER design[1].
价 格：￥电议型 号：T17900产 地：中国大陆
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T1790Fosaprepitant dimeglumine；福沙吡坦二甲葡胺L785298|||MK-0517|||Fosaprepitant dimeglumine salt；福沙匹坦二甲葡胺|||L785
Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent binds selectively to the human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS). This inhibits receptor binding of the endogenous substance P and prevents substance P-induced emesis.
价 格：￥电议型 号：T1790产 地：中国大陆
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T17890cIAP1 Ligand-Linker Conjugates 2 Hydrochloride；化合物 T17890E3 ligase Ligand-Linker Conjugates 37 Hydro
cIAP1 Ligand-Linker Conjugates 2 Hydrochloride is a chemical compound that combines an IAP ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is utilized in the creation of SNIPERs[1].
价 格：￥电议型 号：T17890产 地：中国大陆
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T1786Daclatasvir dihydrochloride；盐酸达拉他韦BMS-790052 dihydrochloride；BMS-790052 dihydrochloride|||盐酸达拉他韦
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is an orally available antiviral agent that inhibits the NS5A region of the hepatitis C virus (HCV) and is used in combination with other oral antiviral agents to treat chronic hepatitis C. Elevations in serum enzyme levels during daclatasvir therapy are uncommon, and it has yet to be convincingly implicated in cases of clinically apparent liver injury with jaundice.
价 格：￥电议型 号：T1786产 地：中国大陆
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T17790DBCO-PEG3-oxyamine；化合物 T17790DBCO-PEG3-oxyamine
DBCO-PEG3-oxyamine is a non-cleavable 3-unit polyethylene glycol linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].
价 格：￥电议型 号：T17790产 地：中国大陆
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T1772MDK83190；化合物Apoptosis Activator 2Apoptosis Activator 2；Apoptosis Activator 2
MDK83190 (Apoptosis Activator 2) is a potent apoptosis activator, induceing caspase-3 activation, PARP cleavage, and DNA fragmentation .
价 格：￥电议型 号：T1772产 地：中国大陆
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T17690Boc-Val-Ala-PAB-PNP；化合物 T17690Boc Val Ala PAB PNP|||Boc-Val-Ala-PAB-PNP|||BocValAlaPABPNP；Boc Val Al
Boc-Val-Ala-PAB-PNP is an ADC linker employed for the synthesis of antibody-drug conjugates (ADCs)[1]. This cleavable compound efficiently facilitates the attachment of drugs to antibodies, allowing for targeted delivery and release of therapeutic agents within the body, making it an important component in ADC development.
价 格：￥电议型 号：T17690产 地：中国大陆
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T17590Biotin-PEG6-azide；生物素-六聚乙二醇-叠氮Biotin-PEG6-N3；Biotin-PEG6-N3|||生物素-六聚乙二醇-叠氮
Biotin-PEG6-azide (Biotin-PEG6-N3) is a biotin-labeled, PEG-based PROTAC linker that can be used in PROTAC synthesis.
价 格：￥电议型 号：T17590产 地：中国大陆
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T1755LY2090314；化合物LY2090314LY2090314
LY2090314, an effective GSK-3α/β inhibitor (IC50: 1.5 nM/0.9 nM), may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, and Pancreatic Cancer.
价 格：￥电议型 号：T1755产 地：中国大陆
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T17490Azido-PEG16-Boc；化合物 T17490Azido-PEG16-Boc
Azido-PEG16-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T17490产 地：中国大陆
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T17390Amine-PEG-amine (MW 2000)；化合物 T17390Amine-PEG-amine (MW 2000)
Amine-PEG-amine (MW 2000) is a polyethylene glycol (PEG) derivative that functions as a linker for PROTAC synthesis. PROTACs are small molecules used for targeted protein degradation [1].
价 格：￥电议型 号：T17390产 地：中国大陆
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T17284Zardaverine；扎达维林BY 290|||B 84290；BY 290|||B 84290
Zardaverine (BY 290) is an orally available, selective and potent PDE3/4 inhibitor with bronchodilator activity and anti-hepatocarcinogenic activity.Zardaverine´s action in platelets is mediated by PDE III isoenzymes and can be used in studies of acute renal failure and chronic airflow obstruction.
价 格：￥电议型 号：T17284产 地：中国大陆
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T17273YM-254890；化合物 T17273YM-254890
YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y1 signal transduction pathway (IC50: below 0.6 μM). YM-254890 is a selective Gαq/11 protein inhibitor. YM-254890 displays no inhibition of other G protein subtypes.
价 格：￥电议型 号：T17273产 地：中国大陆
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T17264Xenalamine；联苯酰胺苯酸Xenazoic acid|||CV58903；Xenazoic acid|||联苯酰胺苯酸|||CV58903
Xenalamine is a synthetic compound of antiviral.
价 格：￥电议型 号：T17264产 地：中国大陆
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T17263XEN907；化合物 T17263XEN907
XEN907 is a novel spiro oxindole NaV1.7 blocker. XEN907 also inhibits hNaV1.7 (IC50: 3 nM).
价 格：￥电议型 号：T17263产 地：中国大陆
