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  • T11323Frakefamide TFA (188196-22-7 free base)；化合物 T11323Frakefamide TFA；Frakefamide TFA

    Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system. Frakefamide TFA is a potent analgesic that acts as a peripheral active μ-selective receptor agonist.

    价 格：￥电议型 号：T11323产 地：中国大陆

  • T11296Flosulide；化合物 T11296ZK 38997|||CGP 28238；ZK 38997|||CGP 28238

    Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.

    价 格：￥电议型 号：T11296产 地：中国大陆

  • T11196Enazadrem；依那扎群Enazadrem

    Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.

    价 格：￥电议型 号：T11196产 地：中国大陆

  • T11154LEG01377 2HCl；EG01377二盐酸盐EG01377 2HCl(2227996-00-9 Free base)；EG01377 2HCl(2227996-00-9 Free base)

    EG01377 2HCl is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1) with a Kd value of 1.32 μM and an IC50 value of 609 nM for both EG01377 2HCl against NRP1-a1 and NRP1-b1.EG01377 exhibits anti-angiogenic, antimigratory and antitumor activities.

    价 格：￥电议型 号：T11154L产 地：中国大陆

  • T11096DRI-C21045；化合物DRI-C21045DRI-C21045

    Dri-c21045 showed concentration-dependent inhibition of NF-kB activation and all CD40L induced by B cell proliferation with IC50 of 17.1 μM and 4.5 μM, respectively. Dri-c21045 is an effective selective inhibitor of CD40-CD40L synergistic stimulator protein-protein interaction (PPI) with IC50 of 0.17 μM.

    价 格：￥电议型 号：T11096产 地：中国大陆

  • T11095DREADD agonist 21 dihydrochloride；化合物 T11095DREADD agonist 21 dihydrochloride (56296-18-5 free base)

    DREADD agonist 21 dihydrochloride is a potent human muscarinic acetylcholine M3 receptors ( hM3Dq ) agonist with EC 50 of 1.7 nM [1].

    价 格：￥电议型 号：T11095产 地：中国大陆

  • T10996Deramciclane；化合物 T10996EGIS-3886；EGIS-3886

    Deramciclane has high affinity for 5-HT2A and 5-HT2C receptors. It acts as an antagonist in both receptor subtypes and has inverse agonist properties for 5-HT2C receptors, but no direct stimulant agonists.

    价 格：￥电议型 号：T10996产 地：中国大陆

  • T10969DC1SMe；化合物 T10969DC1SMe

    DC1 is an ADC cytotoxin, similar to the small groove-binding DNA alkylating agent CC-1065. DC1 can be used to synthesize antibody-drug conjugates targeted to the treatment of cancer. DC1Sme is a DC1 derivative with IC50 values of Ramos, Namalwa, HL60 / s and COLO 205 cancer cells of 22pm, 10pm, 32pm and 250pm, respectively.

    价 格：￥电议型 号：T10969产 地：中国大陆

  • T10968DC0-NH2；化合物 T10968DC0-NH2

    The cytotoxicity of DC0-NH2 is 1000 times that of commonly used anti-cancer drugs (such as doxorubicin). It is the effect part of ADC. It is a simplified simulation of DC1 and has better stability. DC0-NH2 can bind to the small groove of DNA, and then adenine residue is alkylated by its propabenzindole (CBI) component.

    价 格：￥电议型 号：T10968产 地：中国大陆

  • T10967DC_C66；化合物 T10967DC_C66

    DC_C66 DC_C66 has good selectivity for CARM1, PRMT1 (IC50 = 21μM), PRMT6 (IC50 = 47μM) and PRMT5. It is a cell-permeable, selective co-activator related arginine methyltransferase 1 (CARM1) inhibitor with IC50 of 1.8 μM.

    价 格：￥电议型 号：T10967产 地：中国大陆

  • T10966DC-5163；化合物 T10966DC-5163

    DC-5163 is a potent inhibitor of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with IC50 of 176.3 nM and Kd of 3.192 μM. DC-5163 selectively inhibits cancer cell proliferation and induces apoptosis, and partially inhibits the glycolysis pathway.

    价 格：￥电议型 号：T10966产 地：中国大陆

  • T10965DBPR112；化合物DBPR112DBPR112

    DBPR112 is an orally active furanopyrimidine-based EGFR inhibitor with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively. DBPR112 can occupy the ATP-binding site. DBPR112 has significant antitumor efficacy.

    价 格：￥电议型 号：T10965产 地：中国大陆

  • T10964LDB1976 dihydrochloride；DB1976盐酸盐DB1976 hydrochloride|||DB1976 2HCl；DB1976 hydrochloride|||DB1976 2HC

    DB1976 dihydrochloride (DB1976 2HCl) , a transcription factor PU.1 inhibitor with potential anti-inflammatory activity, slowed down inflammation and fibrosis and improved glucose homeostasis and dyslipidemia in mice in in vivo experiments.DB1976 dihydrochloride promotes apoptosis and may be used in studies of metabolic dysfunction and non-alcoholic steatohepatitis.

    价 格：￥电议型 号：T10964L产 地：中国大陆

  • T10964DB1976；化合物DB1976DB1976

    DB1976 is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, KD of 12 nM) in vitro. DB1976 has Apoptosis-inducing effect.

    价 格：￥电议型 号：T10964产 地：中国大陆

  • T10963Dazopride；达佐必利AHR-5531；达佐必利|||AHR-5531

    Dazopride is an antiemetic agent.

    价 格：￥电议型 号：T10963产 地：中国大陆

  • T10961Darenzepine；达仑西平Darenzepine

    Darenzepine is a muscarinic receptor inhibitor.

    价 格：￥电议型 号：T10961产 地：中国大陆

  • T10960LDarbufelone mesylate；达布非龙甲磺酸盐CI-1004 mesylate；CI-1004 mesylate

    Darbufelone mesylate (CI-1004 mesylate) inhibited PGF2α and LTB4 in cells. Darbufelone mesylate inhibited PGHS-2 with IC50 value of 0.19 μM and PGHS-1 with IC50 value of 20 μM.

    价 格：￥电议型 号：T10960L产 地：中国大陆

  • T10960Darbufelone；达布非酮CI-1004；达布非酮|||CI-1004

    Darbufelone (CI-1004) is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 μM for PGHS-2 and PGHS-1.

    价 格：￥电议型 号：T10960产 地：中国大陆

  • T1096Milrinone；米力农Win 47203；Win 47203|||米力农

    Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.

    价 格：￥电议型 号：T1096产 地：中国大陆

  • T10896LCSRM617 hydrochloride；盐酸CSRM617CSRM617 hydrochloride(787504-88-5 Free base)；CSRM617 hydrochloride(78

    CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 ( OC2, a master regulator of androgen receptor) with a K d of 7.43 uM in SPR assays, directly binds to OC2-HOX domain. CSRM617 hydrochloride induces apoptosis through the appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the mouse model of prostate cancer [1]

    价 格：￥电议型 号：T10896L产 地：中国大陆

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