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  • T1475Fesoterodine fumarate；富马酸非索罗定Toviaz|||SPM 907；Toviaz|||SPM 907|||富马酸非索罗定

    Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo into its active metabolite 5-hydroxymethyl tolterodine, which binds and inhibits muscarinic receptors on the bladder detrusor muscle, thereby preventing bladder contractions or spasms caused by acetylcholine.

    价 格：￥电议型 号：T1475产 地：中国大陆

  • T14691BMT-090605；化合物 T14691BMT-090605

    BMT-090605 is a potent, selective AAK1 inhibitor, with an IC50 of 0.6 nM. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 45 and 60 nM, respectively[1]. BMT-090605 shows antinociceptive activity.

    价 格：￥电议型 号：T14691产 地：中国大陆

  • T14690BMS 433796；化合物BMS 433796BMS-289948|||BMS-299897；BMS-289948|||BMS-299897

    BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer´s disease.

    价 格：￥电议型 号：T14690产 地：中国大陆

  • T14680BMS-906024；化合物 BMS-906024Osugacestat|||AL-101|||BM-0018；Osugacestat|||AL-101|||BM-0018

    BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-906024 prevents the activation of all four Notch receptors, and is active against Notch1, -2, -3 and -4 receptors. BMS-906024 prevents the activation of all four Notch receptors, with IC50s of 1.6, 0.7, 3.4 and 2.9 nM for Notch1, -2, -3 and -4 receptors, respectively.

    价 格：￥电议型 号：T14680产 地：中国大陆

  • T14677BMS-690514；化合物BMS-690514BMS-690514

    BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.

    价 格：￥电议型 号：T14677产 地：中国大陆

  • T14590Biotin-PEG3-alcohol；化合物 T14590(+)-Biotin-PEG3-OH；(+)-Biotin-PEG3-OH

    Biotin-PEG3-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

    价 格：￥电议型 号：T14590产 地：中国大陆

  • T14567BI605906化合物 T14567BI605906|||BI 605906|||BI-605906

    BI605906 is an inhibitor of IKKβ. When assayed at 0.1 mM ATP, the IC50 value is 380 nM.

    价 格：￥电议型 号：T14567产 地：中国大陆

  • T14546Bermoprofen；柏莫洛芬AD-1590|||AJ-1590；AD-1590|||AJ-1590

    Bermoprofen (AD-1590) is an orally active non-steroidal anti-inflammatory compound with anti-inflammatory and analgesic activity used in the study of gastric ulcers.

    价 格：￥电议型 号：T14546产 地：中国大陆

  • T14521BDP9066；化合物 BDP9066BDP9066

    BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.

    价 格：￥电议型 号：T14521产 地：中国大陆

  • T14490Talipexole dihydrochloride；盐酸他利克索Domnin|||B-HT 920 dihydrochloride；Domnin|||盐酸他利克索|||B-HT 920 dihydr

    Talipexole dihydrochloride (Domnin) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist, and 5-HT3 receptor antagonist in both rat cortical and intestinal membrane fractions with Ki values of 0.35 μM and 0.22 μM, respectively. It displays antiParkinsonian activity.

    价 格：￥电议型 号：T14490产 地：中国大陆

  • T14390L(2R,3S)-Azelaprag；化合物T14390L(2R,3S)-Azelaprag

    (2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide is an Apelin receptor agonist with an EC50 for Apelin receptors of 0.012 ?M.(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5- methylpyrimidin-2-yl)butane-2-sulfonamide is used in the treatment of heart failure, atherosclerosis, obesity, diabetes mellitus, amyotrophic lateral sclerosis, coronary artery disease, hypertension, strok

    价 格：￥电议型 号：T14390L产 地：中国大陆

  • T14390Azelaprag；化合物AzelapragAMG 986；AMG 986

    Azelaprag (AMG 986) is an effective small-molecule apelin receptor agonist. Azelaprag can be used to treat neurological diseases and cardiovascular diseases.

    价 格：￥电议型 号：T14390产 地：中国大陆

  • T14385AZD9056 hydrochloride；化合物AZD9056 hydrochlorideAZD9056 hydrochloride

    AZD9056 hydrochloride is a P2X7 inhibitor，Which plays a significant role in pain-causing diseases and inflammation.

    价 格：￥电议型 号：T14385产 地：中国大陆

  • T14379AZD5904；化合物AZD5904AZD5904

    AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO, IC50: 140 nM) which has similar potency in mouse and rat.

    价 格：￥电议型 号：T14379产 地：中国大陆

  • T14374AZD2906；化合物 T14374AZD2906

    AZD2906, a selective glucocorticoid receptor (GR) agonist, demonstrates inhibitory concentrations (IC50s) of 2.2 nM in human GR, 0.3 nM in rat peripheral blood mononuclear cells (PBMC), 41.6 nM in human whole blood, and 7.5 nM in rat whole blood, respectively[1]. Additionally, it induces an increase in micronucleated immature erythrocytes within rat bone marrow.

    价 格：￥电议型 号：T14374产 地：中国大陆

  • T14327AS1949490；化合物AS1949490AS1949490

    AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes[1][2]. AS1949490 is a potent and selective SHIP-2 (SH2 domain-containing inositol 5′ phosphatase 2) inhibitor, with an IC50 of 620 nM.

    价 格：￥电议型 号：T14327产 地：中国大陆

  • T14298Rimiducid；AP1903Rimiducid

    Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affinity. Rimiducid is a dimerizer agent that acts by cross-linking the FKBP domains. It dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis.

    价 格：￥电议型 号：T14298产 地：中国大陆

  • T14290Anipamil；阿尼帕米Anipamil

    Anipamil is a long-acting blocker of calcium channel,and for the treatment of cardiovascular disease.

    价 格：￥电议型 号：T14290产 地：中国大陆

  • T14190Alniditan；化合物 T14190Alnitidan；Alnitidan

    Alniditan is a receptors agonist of 5-HT1B/1D in HEK 293 cells (IC50: 1.7 and 1.3 nM). For 5-HT1B/1D receptors, the pKi values are 8.96 and 9.40, respectively.

    价 格：￥电议型 号：T14190产 地：中国大陆

  • T14130Adomeglivant；阿度格列凡LY2409021；LY2409021

    Adomeglivant (LY2409021) is a potent and selective glucagon receptor antagonist. Which is used in clinical trial for type 2 diabetes mellitus.

    价 格：￥电议型 号：T14130产 地：中国大陆

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