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T12553PROTAC EED degrader-1;化合物 T12553PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.
价 格:¥电议型 号:T12553产 地:中国大陆
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T12552PROTAC CDK2/9 Degrader-1;化合物 T12552PROTAC CDK2/9 Degrader-1
PROTAC CDK2/9 Degrader-1 is a potent CDK2 and CDK9 dual degrader(DC50 of 62 nM and 33 nM).
价 格:¥电议型 号:T12552产 地:中国大陆
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T12551PROTAC BRD4 ligand-1;化合物PROTAC BRD4 ligand-1PROTAC BRD4 ligand-1
PROTAC BRD4 ligand-1 is a ligand for BRD4 for Protac GNE-987 and an inhibitor of BET.
价 格:¥电议型 号:T12551产 地:中国大陆
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T11975PROTAC Mcl1 degrader-1;化合物 T11975PROTAC Mcl1 degrader-1
PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 degrader-1, a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM.
价 格:¥电议型 号:T11975产 地:中国大陆
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T11292FKBP12 PROTAC dTAG-7;化合物 T11292dTAG-7;dTAG-7
FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by connecting BET bromodomains to the E3 ubiquitin ligase CRBN. Additionally, it serves as a degrader of FKBP12F36V when FKBP12F36V is expressed in-frame with a targeted protein.
价 格:¥电议型 号:T11292产 地:中国大陆
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T11291FKBP12 PROTAC dTAG-13;化合物 T11291dTAG-13;dTAG-13
FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN. FKBP12 PROTAC dTAG-13 (dTAG-13) is a PROTAC-based heterobifunctional degrader.
价 格:¥电议型 号:T11291产 地:中国大陆
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T10734CDK ligand for PROTAC;化合物 T10734CDK ligand for PROTAC
CDK ligand for PROTAC is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.
价 格:¥电议型 号:T10734产 地:中国大陆
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T10485PROTAC Bcl2 degrader-1;化合物 T10485PROTAC Bcl2 degrader-1
PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).
价 格:¥电议型 号:T10485产 地:中国大陆