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上海陶术生物科技有限公司 主营产品:生物试剂,实验服务等

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  • T14390L(2R,3S)-Azelaprag;化合物T14390L(2R,3S)-Azelaprag

    (2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide is an Apelin receptor agonist with an EC50 for Apelin receptors of 0.012 ?M.(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5- methylpyrimidin-2-yl)butane-2-sulfonamide is used in the treatment of heart failure, atherosclerosis, obesity, diabetes mellitus, amyotrophic lateral sclerosis, coronary artery disease, hypertension, strok

    价 格:¥电议型 号:T14390L产 地:中国大陆

  • T14390Azelaprag;化合物AzelapragAMG 986;AMG 986

    Azelaprag (AMG 986) is an effective small-molecule apelin receptor agonist. Azelaprag can be used to treat neurological diseases and cardiovascular diseases.

    价 格:¥电议型 号:T14390产 地:中国大陆

  • T1439Lacidipine拉西地平SN-305|||拉西地平|||GX-1048|||GR-43659X

    Lacidipine (SN-305) is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does not lead to reflex tachycardia. It displays specificity in the vascular smooth muscle, where it acts as an antihypertensive agent to dilate peripheral arterioles and reduce blood pressure.

    价 格:¥电议型 号:T1439产 地:中国大陆

  • T14389AZD 9272;化合物AZD 9272AZD 9272

    AZD 9272 is a brain-permeable mGluR5 antagonist for the study of gastroesophageal reflux.

    价 格:¥电议型 号:T14389产 地:中国大陆

  • T14388AZD 4017;化合物AZD 4017AZD 4017

    AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).

    价 格:¥电议型 号:T14388产 地:中国大陆

  • T14387AZD9898;化合物AZD9898AZD9898

    AZD9898 is an inhibitor of leukotriene-C4 synthetase with an IC50 of 0.28 nM. AZD9898 can be used in studies about asthma. AZD9898 mitigates the GABA binding and hepatic toxicity signal.

    价 格:¥电议型 号:T14387产 地:中国大陆

  • T14386AZD9567;化合物AZD9567Mizacorat;Mizacorat

    AZD9567 is a potent and orally active and selective non-steroidal glucocorticoid receptor modulator (SGRM) with an IC50 value of 3.8 nM.It has demonstrated excellent efficacy in the Streptococcus cell wall (SCW) reactivation model of joint inflammation.

    价 格:¥电议型 号:T14386产 地:中国大陆

  • T14385AZD9056 hydrochloride;化合物AZD9056 hydrochlorideAZD9056 hydrochloride

    AZD9056 hydrochloride is a P2X7 inhibitor,Which plays a significant role in pain-causing diseases and inflammation.

    价 格:¥电议型 号:T14385产 地:中国大陆

  • T14384AZD8797;化合物KAND567KAN-0440567|||KAND567;KAN-0440567|||KAND567

    AZD8797 (KAND567) is an orally available, selective and potent human CX3CR1-converting antagonist with inhibitory effects on CX3CR1 and CXCR2, and potentially protects against SARS-CoV-2-induced neuronal damage, preventing worsening of nociceptive sensitization and microglial activation in a migraine model of rats following seizures.

    价 格:¥电议型 号:T14384产 地:中国大陆

  • T14383AZD8329;化合物 T14383AZD8329

    AZD8329 is a selectable and potent inhibitor of human recombinant 11β-HSD1 and isolated human adipocyte 11?-HSD1 and is an inhibitor of rat 11β-HSD1 (IC50 - 89nM) and dog recombinant 11β-HSD1. AZD8329 has a higher affinity for 11β-HSD1 than human recombinant 11β-HSD2 and 17 AZD8329 has the ability to reduce the activity of 11β-HSD1 in adipose tissue and liver samples.

    价 格:¥电议型 号:T14383产 地:中国大陆

  • T14382AZD7687;化合物 T14382AZD7687

    AZD7687 is a potent and selective DGAT1 inhibitor with an IC50 value of 80 nM (hDGAT1). IC50 value: 80 nM [1] Target: DGAT1 in vitro: Plasma AZD7687 exposure was measured repeatedly. AZD7687 markedly reduced postprandial TAG excursion with a steep concentration-effect relationship [2]. Postprandial serum TAG excursion was measured during 8 h after a standardized mixed meal with fat energy content of 60% (SMM 60%; five cohorts, 1-20 mg), before (baseline) and after dosing, to assess effects on gu

    价 格:¥电议型 号:T14382产 地:中国大陆

  • T14381AZD7624;化合物AZD7624AZD-7624;AZD-7624

    AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.

    价 格:¥电议型 号:T14381产 地:中国大陆

  • T14380AZD7507;化合物CS-2850AZD7507

    AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity.

    价 格:¥电议型 号:T14380产 地:中国大陆

  • T1438Butoconazole nitrate;硝酸布康唑RS 35887;RS 35887|||硝酸布康唑

    Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate (RS 35887) interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition. This alters cell permeability and leads to growth inhibition. Butoconazole nitrate is active against many dermatophytes and yeasts. It also contains antibacterial effects against some gra

    价 格:¥电议型 号:T1438产 地:中国大陆

  • T14379AZD5904;化合物AZD5904AZD5904

    AZD5904 is a potent and irreversible inhibitor of human Myeloperoxidase (MPO, IC50: 140 nM) which has similar potency in mouse and rat.

    价 格:¥电议型 号:T14379产 地:中国大陆

  • T14378LAZD5582 acetate (1258392-53-8 free base);化合物AZD5582 acetateAZD5582 acetate (1258392-53-8 free base)

    AZD5582 acetate is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis.

    价 格:¥电议型 号:T14378L产 地:中国大陆

  • T14378AZD5582;化合物AZD5582AZD5582

    AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis.

    价 格:¥电议型 号:T14378产 地:中国大陆

  • T14377AZD5423;化合物AZD5423AZD5423

    AZD5423 is an inhaled, potent, selective, and non-steroidal modulator of glucocorticoid receptor (GR) and it effectively reduces allergen-induced responses in subjects with mild allergic asthma.

    价 格:¥电议型 号:T14377产 地:中国大陆

  • T14376AZD4320;化合物AZD4320AZD4320

    AZD4320 is an inhibitor of BH3-mimicking dual BCL2/BCLxL. For KPUM-MS3, KPUM-UH1, and STR-428 cells, the IC50s values are 26 nM, 17 nM, and 170 nM , respectively.

    价 格:¥电议型 号:T14376产 地:中国大陆

  • T14375AZD3988;化合物 AZD3988AZD3988

    AZD3988 is an orally active and highly potent inhibitor of diacylglycerol acyltransferase-1 (DGAT-1) for the study of diabetes and obesity.

    价 格:¥电议型 号:T14375产 地:中国大陆

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