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T80434Heteropodatoxin-2;化合物 Heteropodatoxin-2Heteropodatoxin-2
Heteropodatoxin-2, a 30-amino acid peptide, inhibits the Kv4.2 current in Xenopus laevis oocytes through a voltage-dependent mechanism, exhibiting reduced blocking at more positive potentials [1].
价 格:¥电议型 号:T80434产 地:中国大陆
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T80424Phoenixin-20 TFA;化合物 Phoenixin-20 TFAPNX-20 TFA;PNX-20 TFA
Phoenixin-20 (TFA) (PNX-20 (TFA)) is a bioactive peptide that exerts hormone-like effects in vertebrates, stimulating hypothalamo-pituitary-gonadal hormones and regulating mammalian reproductive processes. Additionally, it enhances neuronal mitochondrial biogenesis through the CREB-PGC-1α pathway and exhibits anxiolytic properties [1] [2] [3].
价 格:¥电议型 号:T80424产 地:中国大陆
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T80423Phoenixin-20;化合物 Phoenixin-20PNX-20;PNX-20
Phoenixin-20 (PNX-20) is a vertebrate bioactive peptide exhibiting hormone-like actions, stimulating the hypothalamo-pituitary-gonadal axis to regulate mammalian reproduction. It enhances neuronal mitochondrial biogenesis through the CREB-PGC-1α pathway and possesses an anxiolytic effect [1] [2] [3].
价 格:¥电议型 号:T80423产 地:中国大陆
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T80338RVG;化合物 RVGRabies Virus Glycoprotein-29|||RVG29|||RDP;Rabies Virus Glycoprotein-29|||RVG29|||RDP
RVG29, a peptide originating from Rabies Virus Glycoprotein, specifically targets the α-7 subunit of nicotinic acetylcholine receptors (AchR) on neuronal cells, thereby facilitating the transport of Mycobacterium tuberculosis antigens to antigen-presenting cells [1].
价 格:¥电议型 号:T80338产 地:中国大陆
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T8022Methyl 2-furoate;2-糠酸甲酯Methyl furan-2-carboxylate;2-糠酸甲酯|||Methyl furan-2-carboxylate
Methyl 2-furoate (Methyl furan-2-carboxylate) is a natural product that found in cocoa and cocoa products
价 格:¥电议型 号:T8022产 地:中国大陆
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T80082Hepcidin-25 (human) (acetate);化合物 Hepcidin-25 (human) (acetate)Hepcidin-25 (human) (acetate)
Hepcidin-25 (human) acetate is a modulator of iron metabolism that demonstrates anti-inflammatory and antibacterial effects through the modulation of iron-mediated oxidant injury [1].
价 格:¥电议型 号:T80082产 地:中国大陆
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T79917FAP-IN-2;化合物 FAP-IN-2FAP-IN-2
FAP-IN-2 is a 99mTc-labeled, isonitrile-containing derivative of a fibroblast activation protein (FAPI) inhibitor suitable for tumor imaging [1].
价 格:¥电议型 号:T79917产 地:中国大陆
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T79885HSD17B13-IN-2;化合物 HSD17B13-IN-2HSD17B13-IN-2
HSD17B13-IN-2 (compound 1) serves as a potent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13) with demonstrable activity in cellular experiments [1].
价 格:¥电议型 号:T79885产 地:中国大陆
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T79881CDK7-IN-25;化合物 CDK7-IN-25CDK7-IN-25
CDK7-IN-25 (CY-16-1) is a potent CDK7 inhibitor with an IC50 value of less than 1nM, utilized in cancer research [1].
价 格:¥电议型 号:T79881产 地:中国大陆
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T79821DGKα-IN-2;化合物 DGKα-IN-2DGKα-IN-2
DGKα-IN-2 (example 48), a potent DGKα inhibitor with an IC50 of 0.9 nM, exhibits potential for cancer and immunological research by significantly augmenting the anti-tumor efficacy of anti-PD-1 therapy through the amplification of T cell proliferation and function.
价 格:¥电议型 号:T79821产 地:中国大陆
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T79812BTK-IN-27;化合物 BTK-IN-27BTK-IN-27
BTK-IN-27 (example 8), a potent BTK inhibitor with an IC50 of 0.2 nM, demonstrates anti-proliferative effects in TMD8 cells with an IC50 of less than 5 nM. It is suitable for the research of various conditions including cancer, lymphoma, leukemia, and immunological diseases [1].
价 格:¥电议型 号:T79812产 地:中国大陆
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T79810Porcn-IN-2;化合物 Porcn-IN-2Porcn-IN-2
Porcn-IN-2 (Example 107) is a potent Wnt pathway inhibitor, exhibiting an IC50 of 0.05 nM. It has applications in cancer research, including sarcoma, melanoma, skin cancer, hematological tumors, lymphoma, carcinoma, and leukemia [1].
价 格:¥电议型 号:T79810产 地:中国大陆
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T79800pan-KRAS-IN-2;化合物 pan-KRAS-IN-2pan-KRAS-IN-2
Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of ≤10 nM against KRAS wild type and its mutants (G12D, G12C, G12V, G12S, G12A, Q61H), while showing significantly reduced inhibition, with an IC50 >10 μM, for the KRAS G13D mutant [1].
价 格:¥电议型 号:T79800产 地:中国大陆
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T79798PHD-IN-2;化合物 PHD-IN-2PHD-IN-2
PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 of less than 2.5 μM. It is applicable for research purposes across various medical fields, including cardiovascular, metabolic, hematological, pulmonary, kidney, liver, and wound healing disorders, as well as cancer [1].
价 格:¥电议型 号:T79798产 地:中国大陆
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T79792αvβ1 integrin-IN-2;化合物 αvβ1 integrin-IN-2αvβ1 integrin-IN-2
αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively. Additionally, this compound inhibits a range of other integrins, with IC50 values of 380 nM (ανβ3), 280 nM (ανβ5), 230 nM (ανβ6), and 87 nM (ανβ8) as determined by the SPRA assay [1].
价 格:¥电议型 号:T79792产 地:中国大陆
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T79771HDAC6-IN-22;化合物 HDAC6-IN-22HDAC6-IN-22
HDAC6-IN-22 (compound 30), an HDAC6 inhibitor, exhibits an IC50 of 4.63 nM and demonstrates antiproliferative effects against multiple myeloma both in vitro and in vivo. It induces cell cycle arrest in the G2 phase and promotes apoptosis via the mitochondrial pathway [1].
价 格:¥电议型 号:T79771产 地:中国大陆
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T79769HDAC6-IN-23;化合物 HDAC6-IN-23HDAC6-IN-23
HDAC6-IN-23 (compound 9), an orally active inhibitor of HDAC6 [1], displays selective enzymatic inhibition.
价 格:¥电议型 号:T79769产 地:中国大陆
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T79761MAO-B-IN-25;化合物 MAO-B-IN-25MAO-B-IN-25
MAO-B-IN-25 (compound 92) is a selective inhibitor of monoamine oxidase B (MAO-B), exhibiting inhibitory half-maximal inhibitory concentrations (IC50) of 240 nM for MAO-B and 0.5 nM for MAO-A [1].
价 格:¥电议型 号:T79761产 地:中国大陆
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T79745IDH2R140Q-IN-2;IDH2R140Q 抑制剂1IDH2R140Q-IN-2
IDH2R140Q-IN-2 is an orally active and potent IDH2R140Q inhibitor with an IC50 of 29 nM.IDH2R140Q-IN-2 possesses potential antitumour activity, reducing D2HG production in TF-1 cell lines carrying the IDH2R140Q mutation (IC50 of 10 nM) and inhibiting tumour tissue D2HG levels.IDH2R140Q-IN-2 is suitable for the study of acute myeloid leukaemia (AML).
价 格:¥电议型 号:T79745产 地:中国大陆
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T79739CYP51/PD-L1-IN-2;化合物 CYP51/PD-L1-IN-2CYP51/PD-L1-IN-2
CYP51/PD-L1-IN-2 (compound L20), a quinazoline with antifungal properties, is a potent dual inhibitor targeting both CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.017 μM). The compound promotes early apoptosis in the fungal cell cycle, markedly diminishes intracellular proteins IL-2, NLRP3, and NF-κBp65, causes mitochondrial damage and ROS build-up, culminating in fungal cell lysis and death [1].
价 格:¥电议型 号:T79739产 地:中国大陆