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T4674SB297006;化合物SB 297006SB 297006;SB 297006
SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells. It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg).
价 格:¥电议型 号:T4674产 地:中国大陆
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T4524SBC-110736;化合物SBC-110736SBC110736;SBC110736
SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor
价 格:¥电议型 号:T4524产 地:中国大陆
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T4516Sitsirikine;化合物 T4516Sitsirikine
Sitsirikine is a natural product from Catharanthus roseus.
价 格:¥电议型 号:T4516产 地:中国大陆
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T4424SLV-2436;化合物SLV2436SEL-201|||SLV 2436|||SEL201-88;SEL-201|||SLV 2436|||SEL201-88
SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM).
价 格:¥电议型 号:T4424产 地:中国大陆
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T4263BAY 61-3606;化合物BAY 61-3606Syk inhibitor IV;2-[[7-(3,4-二甲氧基苯基)咪唑并[1,2-C]嘧啶-5-基]氨基]-3-吡啶甲酰胺|||Syk inhi
BAY 61-3606 (Syk inhibitor IV) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
价 格:¥电议型 号:T4263产 地:中国大陆
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T41257SJ6986;化合物SJ6986SJ6986
SJ6986 is a potent, selective and orally active GSPT1/2 degrader. SJ6986 degrades GSPT1 with a DC 50 of 2.1 nM (D max 99%) [1].
价 格:¥电议型 号:T41257产 地:中国大陆
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T41256SP-96;化合物SP-96SP-96
SP-96 is a highly effective and selective inhibitor of Aurora B with an IC50 of 0.316 nM. SP-96 shows selective growth inhibition in NCI60 screening, including MDA-MD-468 (GI50=107 nM). SP-96 can be used in triple negative breast cancer studies.
价 格:¥电议型 号:T41256产 地:中国大陆
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T40121SHP2-D26;SHP2-D26SHP2-D26;SHP2-D26
SHP2-D26 is a highly potent and effective SHP2 degrader. Its mechanism of action involves the induction of SHP2 degradation through binding to VHL-1 and SHP2 proteins. Additionally, the degradation of SHP2 induced by SHP2-D26 is dependent on neddylation and proteasome activity.
价 格:¥电议型 号:T40121产 地:中国大陆
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T39800S2116;S2116S2116
S2116 is a powerful inhibitor of lysine-specific demethylase 1 (LSD1), and it is a derivative of N-alkylated tranylcypromine (TCP). S2116 exhibits its inhibitory effects by increasing H3K9 methylation and inducing reciprocal H3K27 deacetylation at super-enhancer regions. In TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells, S2116 triggers apoptosis by repressing the transcription of NOTCH3 and TAL1 genes. Furthermore, S2116 demonstrates significant growth retardation of T-ALL cells
价 格:¥电议型 号:T39800产 地:中国大陆
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T37191Mu-6S-Palm-β-Glc;化合物 Mu-6S-Palm-β-GlcMu-6S-Palm-β-Glc
Mu-6S-Palm-β-Glc is a fluorogenic substrate of palmitoyl-protein thioesterase (PPT, also known as CLN1), a lysosomal hydrolase that removes long-chain fatty acyl groups from modified cysteine residues in proteins. Mu-6S-Palm-β-Glc is cleaved by PPT/CLN1 to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM
价 格:¥电议型 号:T37191产 地:中国大陆
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T35674StRIP16;StRIP16StRIP16
Rab8a GTPase-binding stapled peptide (Kd = 12.7 μM). Cell permeable; localizes to the endomembrane system.
价 格:¥电议型 号:T35674产 地:中国大陆
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T34756Sydnogluton;化合物 T34756Sydnocarb - glutamic acid;Sydnocarb - glutamic acid
Sydnogluton, as a combination of sydnocarb and glutamic acid, can exert psychostimulating, thermogenic, and actoprotective effects.
价 格:¥电议型 号:T34756产 地:中国大陆
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T34726Strinoline;化合物 T34726Strinolinum|||Strinolina;Strinolinum|||Strinolina
Strinoline is a bioactive chemical.
价 格:¥电议型 号:T34726产 地:中国大陆
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T34709ST-1006;化合物ST-1006ST 1006;ST 1006
ST-1006 is a potent histamine H4 receptor agonist (pKi: 7.94).ST-1006 has anti-inflammatory effects.ST-1006 is a potent inducer of basophil migration and induces basophil migration.ST-1006 is a potent inducer of basophil migration. ST-1006 has anti-inflammatory and anti-pruritic effects.
价 格:¥电议型 号:T34709产 地:中国大陆
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T34706SRI-29132;化合物 T34706SRI29132|||SRI 29132|||TPZ-11|||TPZ 11|||TPZ11;SRI29132|||SRI 29132|||TPZ-11|||T
SRI-29132 is potent; highly permeant of the blood-brain barrier; and selective for LRRK2 kinase activity, therefore effective in attenuating pro-inflammatory responses in macrophages and in rescuing neurite retraction phenotypes in neurons.
价 格:¥电议型 号:T34706产 地:中国大陆
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T34686Sonoflora 1;化合物 T34686SF 1|||SF-1|||Sonoflora1|||Sonoflora-1|||SF1;SF 1|||SF-1|||Sonoflora1|||Sonofl
Sonoflora 1, also known as SF1, a PDT photosensitivizer. Chemically, SF1 is an analog of chlorophyll in that its macrocycle backbone is porphyrin-based and the center of the porphyrin ring consists of a metal ion. Preclinical studies showed that SF1 had very high sonodynamic as well as photodynamic activity. The clinically tested results demonstrated positive therapeutic effects for treating patients with advanced refractory breast cancers that had failed to respond to conventional chemotherapy.
价 格:¥电议型 号:T34686产 地:中国大陆
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T34666SNAP-8719;化合物 T34666SNAP8719;SNAP8719
SNAP-8719 is a selective antagonist of α1D-AR. SNAP-8719 showed better selectivity for α1D-AR and lower binding affinity for the 5-HT1A receptor.
价 格:¥电议型 号:T34666产 地:中国大陆
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T34636S-Hydroxyethylhomocysteine;化合物 T34636S-Hydroxyethylhomocysteine
S-Hydroxyethylhomocysteine is a bioactive chemical.
价 格:¥电议型 号:T34636产 地:中国大陆
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T34606Selenohomolysine;化合物 T34606Selenohomolysine
Selenohomolysine is a selenium-containing amino acid.
价 格:¥电议型 号:T34606产 地:中国大陆
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T34586Scillirubroside;化合物 T34586Scillirubroside
Scillirubroside is a tetraploid.
价 格:¥电议型 号:T34586产 地:中国大陆