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T79121ATR-IN-29；化合物 ATR-IN-29ATR-IN-29
ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].
价 格：￥电议型 号：T79121产 地：中国大陆
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T79116JAK-IN-28；化合物 JAK-IN-28JAK-IN-28
JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].
价 格：￥电议型 号：T79116产 地：中国大陆
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T79113BTK-IN-25；化合物 BTK-IN-25BTK-IN-25
BTK-IN-25 (compound 71) is a potent BTK inhibitor, demonstrating an IC50 of 0.77 nM against BTK(C481S) and achieving an IC50 of 1 nM in DOHH2 cells [1].
价 格：￥电议型 号：T79113产 地：中国大陆
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T79110JAK-IN-27；化合物 JAK-IN-27JAK-IN-27
JAK-IN-27, also known as compound 1, is an orally active, potent inhibitor of the JAKS family kinases, displaying inhibitory concentrations (IC50s) of 3.0 nM for TYK2, 7.7 nM for JAK1, and 629.6 nM for JAK3. Moreover, JAK-IN-27 impedes IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells with an IC50 of 23.7 nM [1].
价 格：￥电议型 号：T79110产 地：中国大陆
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T79099RET-IN-23；化合物 RET-IN-23RET-IN-23
RET-IN-23 (compound 17) is a potent, orally active inhibitor of RET, displaying IC50 values of 1.32 nM for RET-WT, 2.50 nM for RET-CCDC6, 6.54 nM for RET-V804L, 1.03 nM for RET-V804M, and 1.47 nM for RET-M918T. The compound demonstrates significant anti-tumor activity [1].
价 格：￥电议型 号：T79099产 地：中国大陆
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T79083HSP90-IN-22；化合物 HSP90-IN-22HSP90-IN-22
HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM in SKBr3 breast cancer cells.
价 格：￥电议型 号：T79083产 地：中国大陆
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T79061VMAT2-IN-2 tosylate；化合物 VMAT2-IN-2 tosylateVMAT2-IN-2 tosylate
VMAT2-IN-2 tosylate is a potent inhibitor of VMAT2 and is applicable in the research of tardive dyskinesia [1].
价 格：￥电议型 号：T79061产 地：中国大陆
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T79058ATR-IN-24；化合物 ATR-IN-24ATR-IN-24
ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].
价 格：￥电议型 号：T79058产 地：中国大陆
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T79055Hedgehog IN-2；化合物 Hedgehog IN-2Hedgehog IN-2
Hedgehog IN-2 (Compound 20) functions as an inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of <0.003 μM in C3H10T1/2 cells [1].
价 格：￥电议型 号：T79055产 地：中国大陆
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T79054TRPC3/6-IN-2；化合物 TRPC3/6-IN-2TRPC3/6-IN-2
TRPC3/6-IN-2 is a potent inhibitor of TRPC3 and TRPC6, exhibiting IC50 values of 16 nM for TRPC3 and 29.8 nM for TRPC6, respectively [1].
价 格：￥电议型 号：T79054产 地：中国大陆
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T79046CDK4-IN-2；化合物 CDK4-IN-2CDK4-IN-2
CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].
价 格：￥电议型 号：T79046产 地：中国大陆
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T79037CDK9-IN-23；化合物 CDK9-IN-23CDK9-IN-23
CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].
价 格：￥电议型 号：T79037产 地：中国大陆
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T79035PRMT5-IN-28；化合物 PRMT5-IN-28PRMT5-IN-28
PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processes including gene transcription, mRNA splicing, DNA repair, protein cellular localization, cell fate determination, and signal transduction. Dysregulated PRMT5 activity contributes to oncogenesis by promoting cancer cell proliferation, apoptosis resistance, invasion, metastasis, and impacting immune evasion [1].
价 格：￥电议型 号：T79035产 地：中国大陆
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T79033ATR-IN-22；化合物 ATR-IN-22ATR-IN-22
ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM and demonstrates anti-tumor activity in colon cancer [1].
价 格：￥电议型 号：T79033产 地：中国大陆
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T79031ATR-IN-21；化合物 ATR-IN-21ATR-IN-21
ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].
价 格：￥电议型 号：T79031产 地：中国大陆
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T79012MDM2/XIAP-IN-2；化合物 MDM2/XIAP-IN-2MDM2/XIAP-IN-2
MDM2/XIAP-IN-2 is a dual inhibitor targeting murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP). It promotes the degradation of MDM2 and impedes translation of XIAP mRNA, effectively inhibiting cancer cell proliferation. Notably, it exhibits potent activity against the acute lymphoblastic leukemia cell line EU-1, with an IC50 of 0.3 μM [1].
价 格：￥电议型 号：T79012产 地：中国大陆
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T78975IDO1-IN-22；化合物 IDO1-IN-22IDO1-IN-22
IDO1-IN-22 (Compound 3) is an inhibitor of IDO1, demonstrating potent activity with biochemical hIDO1 IC50 of 67.4 nM and HeLa hIDO1 IC50 of 17.6 nM. It exhibits excellent antitumor efficacy in an LLC xenograft model and possesses a desirable pharmacokinetic (PK) profile [1].
价 格：￥电议型 号：T78975产 地：中国大陆
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T78968TRK-IN-23；化合物 TRK-IN-23TRK-IN-23
TRK-IN-23 (compound 24b) is a potent, orally active inhibitor of TRK with IC50s of 0.5 nM for TRKA, 9 nM for TRKC, 14 nM for TRKA G595R, 4.4 nM for TRKA F589L, and 4.8 nM for TRKA G667C. It induces apoptosis in Ba/F3-TRKAG595R and Ba/F3-TRKAG667C cells [1].
价 格：￥电议型 号：T78968产 地：中国大陆
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T78960FABP4-IN-2；化合物 FABP4-IN-2FABP4-IN-2
FABP4-IN-2 (Compd 10g), a selective and orally active FABP4 inhibitor, exhibits K i values of 0.51 μM for FABP4 and 33.01 μM for FABP3, demonstrating its specificity towards FABP4. It is utilized in research investigating inflammatory diseases [1].
价 格：￥电议型 号：T78960产 地：中国大陆
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T78959ATR-IN-23；化合物 ATR-IN-23ATR-IN-23
ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility in researching DNA damage response (DDR)-deficient cancers [1].
价 格：￥电议型 号：T78959产 地：中国大陆
