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T10214A7132;化合物A7132A7132
A7132 is an antibacterial agent and possesses broad and potent antibacterial activity.
价 格:¥电议型 号:T10214产 地:中国大陆
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T10213A-437203;化合物A-437203ABT-925|||A37203|||Lu201640;ABT-925|||A37203|||Lu201640
A-437203 (Lu201640) is A kind of based on 1 h - pyrimidin - 2 - one sca ? old, selective, new powerful d3 receptor antagonist, on D2, d3, and D4 receptor, Ki value 71, respectively 1.6 and 6220 nM.
价 格:¥电议型 号:T10213产 地:中国大陆
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T10210A-9758;化合物 T10210A-9758
A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis.
价 格:¥电议型 号:T10210产 地:中国大陆
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T10209A-887826;化合物 T10209A-887826
A-887826 is a selective, orally bioavailable, and voltage-dependent Na(v1.8) channel blocker (IC50: 11 nM). It attenuates neuropathic tactile allodynia in vivo.
价 格:¥电议型 号:T10209产 地:中国大陆
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T10207A 438079;化合物A 438079A 438079
A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
价 格:¥电议型 号:T10207产 地:中国大陆
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T10204A-317491 sodium salt hydrate;化合物 T10204A-317491 sodium salt hydrate (475205-49-3 free base);A-317491
A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors.
价 格:¥电议型 号:T10204产 地:中国大陆
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T10202A 1070722;化合物A 1070722A 1070722
A 1070722 is a potent and selective GSK-3 inhibitor, shows high affinity GSK-3α(Ki = 0.6 nM) and GSK-3β(Ki = 0.6 nM). It can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain.
价 格:¥电议型 号:T10202产 地:中国大陆
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T10199GNF-PF-3777;化合物GNF-PF-37778-Nitrotryptanthrin;8-Nitrotryptanthrin
GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
价 格:¥电议型 号:T10199产 地:中国大陆
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T101978,?9-?Epoxy-?3-?isobutyryloxy-?10-?(2-?methylbutanoyl)?thymol;8,9-环氧-3-异丁酰-10-(2-甲基丁酰) 百里草酚8-9-epoxy
8,9-Epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol is a chemical composition of essential oils from Telekia speciosa. It also shows marked antipro-liferative activity against human cancer cell lines in vitro.
价 格:¥电议型 号:T10197产 地:中国大陆
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T101967α-Hydroxy-4-cholesten-3-one;化合物 T101967α-Hydroxy-4-cholesten-3-one
7α-Hydroxy-4-cholesten-3-one is an intermediate in the synthesis of bile acids from cholesterol. It is a PXR agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss and other diseases associated with defective bile acid biosynthesis.It is the physiological substrate for CYP8B1.
价 格:¥电议型 号:T10196产 地:中国大陆
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T101957-O-Geranylscopoletin;化合物 T101957-Geranyloxy-6-methoxycoumarin;7-Geranyloxy-6-methoxycoumarin
7-O-Geranylscopoletin is a natural coumarin from the root of Atalantia monophylla. Various parts of this plant have been used for folk medicine for several purposes such as the treatment of chronic rheumatism, antispasmodic, paralysis, hemiplegia, and stimulant.
价 格:¥电议型 号:T10195产 地:中国大陆
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T101947-Methylguanine;化合物 T101947-Methylguanine
7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents and used as a probe of DNA–protein interactions and a key component of the DNA sequencing method.
价 格:¥电议型 号:T10194产 地:中国大陆
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T10191L7-Chlorokynurenic acid;7-氯犬尿酸7-chloro-4-hydroxy-2-carboxyquinoline|||7-CKA;7-chloro-4-hydroxy-2-carb
7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.
价 格:¥电议型 号:T10191L产 地:中国大陆
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T101917-Chlorokynurenic acid sodium salt化合物 T101917-CKA sodium salt
7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the NMDA receptor (IC50: 0.56 μM). It is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles (Ki: 0.59 μM).
价 格:¥电议型 号:T10191产 地:中国大陆
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T101907-BIA;化合物7-BIA7-BIA
7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with anti-addictive properties and can be used in the study of neuropathic pain.
价 格:¥电议型 号:T10190产 地:中国大陆
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T101897-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene;化合物 T101897-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifen
7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is a liver receptor homolog-1 (LRH-1) antagonist (IC50: 3.1 μM).
价 格:¥电议型 号:T10189产 地:中国大陆
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T101886RK73;化合物6RK736RK73
6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 ?M). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 ?M).
价 格:¥电议型 号:T10188产 地:中国大陆
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T101795β-?Dutasteride;化合物 T101795β-?Dutasteride
5β-Dutasteride is the S configuration of Dutasteride. It is a potent inhibitor of both 5 alpha-reductase isozymes.
价 格:¥电议型 号:T10179产 地:中国大陆
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T10177(5Z,2E)-CU-3;化合物(5Z,2E)-CU-3(5Z,2E)-CU-3
(5Z,2E)-CU-3 is a potent and selective inhibitor of DGKα isozyme with an IC50 value of 0.6 μM and inhibition of DGKα by competing ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 is selective, targeting the catalytic region of DGKα, but does not act on the regulatory region. (5Z,2E)-CU-3 has antitumor and immunogenic effects, promoting apoptosis of cancer cells and activation of T cells.
价 格:¥电议型 号:T10177产 地:中国大陆
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T10176TRPV antagonist 1;化合物 T10176TRPV antagonist 1
TRPV antagonist 1 is an antagonist of transient receptor potential vanilloid (TRPV; IC50 < 250 nM).
价 格:¥电议型 号:T10176产 地:中国大陆