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T1773Afatinib Dimaleate;双马来酸盐阿法替尼BIBW2992|||Afatinib|||BIBW 2992MA2|||Afatinib (BIBW2992) Dimaleate;马来酸阿法
Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic activity.
价 格:¥电议型 号:T1773产 地:中国大陆
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T17729Cl-C6-PEG4-C3-COOH;化合物 T17729Cl-C6-PEG4-C3-COOH
Cl-C6-PEG4-C3-COOH, a PROTAC linker, is a suitable component for synthesizing chloroalkane-containing PROTACs (HaloPROTACs).
价 格:¥电议型 号:T17729产 地:中国大陆
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T17629Bis-PEG29-acid;化合物 T17629Bis-PEG29-acid
Bis-PEG29-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T17629产 地:中国大陆
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T17529BCN-PEG3-Biotin;化合物 T17529BCN-PEG3-Biotin
BCN-PEG3-Biotin is a non-cleavable three-unit PEG linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].
价 格:¥电议型 号:T17529产 地:中国大陆
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T17429Amino-PEG36-acid;化合物 T17429Amino-PEG36-acid
Amino-PEG36-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T17429产 地:中国大陆
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T173292-Bromo-2,2-dimethyl-acetamido-PEG3-acid;化合物 T173292-Bromo-2,2-dimethyl-acetamido-PEG3-acid
2-Bromo-22-dimethyl-acetamido-PEG3-acid is a polyethylene glycol (PEG) derivative commonly employed as a PEG-based PROTAC linker during PROTAC synthesis[1].
价 格:¥电议型 号:T17329产 地:中国大陆
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T17299(-)-Indolactam V;化合物 T17299Indolactam V;Indolactam V
(-)-Indolactam V is a PKC activator (Kis: 3.36 nM, 1.03 μM for η-CRD2 , γ-CRD2). (-)-Indolactam V also has the Kds are 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B). It has antitumor activity.
价 格:¥电议型 号:T17299产 地:中国大陆
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T17298Zylofuramine;化合物 T17298Zylofuramine
Zylofuramine is a stimulant of psychomotor.
价 格:¥电议型 号:T17298产 地:中国大陆
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T17297ZXH-3-26;化合物 T17297ZXH-3-26
ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM).
价 格:¥电议型 号:T17297产 地:中国大陆
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T17296Zotatifin;化合物 T17296eFT226;eFT226
Zotatifin is a potent and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM). Zotatifin effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM).
价 格:¥电议型 号:T17296产 地:中国大陆
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T17295ZM39923;化合物 T17295ZM39923
ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).
价 格:¥电议型 号:T17295产 地:中国大陆
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T17294ZL0454;化合物 T17294ZL0454
ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).
价 格:¥电议型 号:T17294产 地:中国大陆
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T17293ZL006;化合物ZL006ZL006
ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.
价 格:¥电议型 号:T17293产 地:中国大陆
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T17292ZK159222;化合物 T17292ZK159222
ZK159222 is an effective 1α,25-(OH)2D3 receptor (VDR) agonist. ZK159222 has a partial agonistic character.
价 格:¥电议型 号:T17292产 地:中国大陆
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T17291ZK 216348;化合物 T17291(+)-ZK 216348;(+)-ZK 216348
ZK 216348 also binds to Progesterone and mineralocorticoid receptors (IC50s: 20.4 nM and 79.9 nM, respectively). ZK 216348 is a nonsteroidal selective glucocorticoid receptor agonist (IC50: 20.3 nM). ZK 216348 has an anti-inflammatory activity similar to Prednisolone.
价 格:¥电议型 号:T17291产 地:中国大陆
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T17284Zardaverine;扎达维林BY 290|||B 84290;BY 290|||B 84290
Zardaverine (BY 290) is an orally available, selective and potent PDE3/4 inhibitor with bronchodilator activity and anti-hepatocarcinogenic activity.Zardaverine´s action in platelets is mediated by PDE III isoenzymes and can be used in studies of acute renal failure and chronic airflow obstruction.
价 格:¥电议型 号:T17284产 地:中国大陆
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T17246VU0529331;化合物 T17246VU0529331
VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel activator (EC50s: 5.1 μM and 5.2 μM for GIRK2 and GIRK1/2 in HEK293 cells, respectively). It is also effective on the GIRK4 homomeric channel.
价 格:¥电议型 号:T17246产 地:中国大陆
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T17229Verubulin化合物 T17229MPC 6827
Verubulin is a microtubule-disrupting agent with potent and broad-spectrum in vitro and in vivo cytotoxic activities.
价 格:¥电议型 号:T17229产 地:中国大陆
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T17129Tos-PEG3;化合物 T17129Tos-PEG3
Tos-PEG3, a PEG-based PROTAC linker, is suitable for synthesizing PROTACs and 3´-aminooxy oligonucleotide solid supports[1].
价 格:¥电议型 号:T17129产 地:中国大陆
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T17059Tetrahydrouridine;四氢尿苷NSC 112907|||NSC112907|||NSC-112907;NSC 112907|||NSC112907|||四氢尿苷|||NSC-112907
Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator. It can be used in cancer treatment to make tumor cells more sensitive to radiation therapy. THU is a competitive cytidine deaminase(CDA) inhibitor that inhibits deamination in the catabolism of cytotoxic deoxycytidine analogs such as ara-C and Gemcitabine.
价 格:¥电议型 号:T17059产 地:中国大陆