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T15736Leriglitazone;化合物 T15736Hydroxypioglitazone;Hydroxypioglitazone
Leriglitazone, a metabolite of pioglitazone, binds to the PPARγ C-terminal ligand-binding domain (Ki: 1.2 μM) and induces transcriptional efficacy of the PPARγ (EC50: 680 nM). Leriglitazone PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface.
价 格:¥电议型 号:T15736产 地:中国大陆
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T1569Tigecycline;替加环素GAR-936;替加环素|||GAR-936
Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex.
价 格:¥电议型 号:T1569产 地:中国大陆
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T15666KP136;化合物 KP136AL136;AL136
KP136 (AL136) is an orally active anti-allergic compound that inhibits histamine release and is used in studies of asthma and allergic edema.
价 格:¥电议型 号:T15666产 地:中国大陆
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T15636K-252a;化合物 T15636Antibiotic K 252a|||Antibiotic SF 2370|||SF2370;Antibiotic K 252a|||Antibiotic SF 2
K-252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi. K-252a inhibits protein kinase (IC50: 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively).
价 格:¥电议型 号:T15636产 地:中国大陆
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T15560Iloprost;伊洛前列素ZK 36374|||Ciloprost;ZK 36374|||Ciloprost|||伊洛前列素
Iloprost is a synthetic analogue of prostacyclin PGI2. Iloprost commonly employed in the treatment of peripheral vascular disease and also indicated in the treatment of patients affected by systemic sclerosis (SSc) in the presence of severe Raynaud´s phenomenon (RP).
价 格:¥电议型 号:T15560产 地:中国大陆
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T15536Hydroxy-PEG6-acid;化合物 T15536Hydroxy-PEG6-acid
Hydroxy-PEG6-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T15536产 地:中国大陆
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T15456GYKI 53655 hydrochlorideGYKI 53655 盐酸盐GYKI53655 hydrochloride|||LY300168 hydrochloride
GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.
价 格:¥电议型 号:T15456产 地:中国大陆
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T15454GW843682X;化合物GW843682XGW843682;GW843682
GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).
价 格:¥电议型 号:T15454产 地:中国大陆
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T15436GSK2838232;化合物GSK2838232GSK2838232
GSK2838232 inhibit HIV reverse transcriptase activity across a broad panel of HIV-1 isolates,GSK2838232 is novel human immune virus (HIV) maturation inhibitor.
价 格:¥电议型 号:T15436产 地:中国大陆
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T15381Gisadenafil;吉沙那非UK-369003;UK-369003|||吉沙那非
Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.
价 格:¥电议型 号:T15381产 地:中国大陆
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T15369Lgamma-DGG acetate(6729-55-1 free base);化合物gamma-DGG acetateγDGG|||γ-D-Glutamylglycine;γDGG|||γ-D-Glu
gamma-DGG acetate(6729-55-1 free base) (γ-D-Glutamylglycine) is a competitive blocker of AMPA receptor.
价 格:¥电议型 号:T15369L产 地:中国大陆
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T15369gamma-DGG化合物 T15369γDGG|||γ-D-Glutamylglycine
gamma-DGG is a competitive blocker of AMPA receptor.
价 格:¥电议型 号:T15369产 地:中国大陆
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T15368LGalantide acetate;化合物Galantide醋酸盐Galantide acetate(138579-66-5 Free base);Galantide acetate(138579-6
Galantide acetate, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide acetate recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide acetate dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide acetate appears to bind to a single population of SP receptors (KD~40 nM).
价 格:¥电议型 号:T15368L产 地:中国大陆
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T15368Galantide;化合物 T15368Galantide
Galantide is a reversible and non-specific antagonist of galanin receptor.
价 格:¥电议型 号:T15368产 地:中国大陆
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T15367Gadoxetate Disodium;钆塞酸二钠Gd-EOB-DTPA Disodium|||ZK 139834;Gd-EOB-DTPA Disodium|||钆塞酸二钠|||ZK 139834
Gadoxetate Disodium is used to evaluate focal liver lesions, such as hepatocellular carcinoma or liver metastasis on T1-weighted imaging. It is a contrast agent in magnetic resonance imaging (MRI) of the hepatobiliary system. It accumulates in normal, functioning hepatocytes.
价 格:¥电议型 号:T15367产 地:中国大陆
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T15366Gabapentin enacarbil加巴喷丁酯XP-13512|||加巴喷丁酯
Gabapentin enacarbil (XP-13512) is a prodrug for the anticonvulsant and analgesic drug gabapentin. Gabapentin enacarbil provides sustained dose-proportional exposure to gabapentin and predictable bioavailability.
价 格:¥电议型 号:T15366产 地:中国大陆
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T15365G-744;化合物 T15365G-744
G-744 is a selective and orally active inhibitor of Btk (IC50: 2 nM). G-744 is well-tolerated, metabolically stable. It also has an efficacious to treat arthritis.
价 格:¥电议型 号:T15365产 地:中国大陆
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T15364G-1;化合物G-1G-1
G-1 is a nonsteroidal, high-affinity and selective GPR30 agonist (Ki: 11 nM).
价 格:¥电议型 号:T15364产 地:中国大陆
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T15363FzM1.8;化合物FzM1.8FzM1.8
FzM1.8 is an allosteric FZD4 agonist with a pEC50 of 6.4. FzM1.8 binds to FZD4, promotes TCF/LEF transcriptional activity in the absence of any WNT ligand, and activates the WNT/β-catenin pathway.
价 格:¥电议型 号:T15363产 地:中国大陆
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T15362FX-11;化合物FX-11LDHA Inhibitor FX11;LDHA Inhibitor FX11
FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. FX-11 appeared antitumor activity during xenotransplantation of lymphoma and pancreatic cancer.
价 格:¥电议型 号:T15362产 地:中国大陆