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  • T14672BMS-248360；化合物 T14672BMS-248360

    BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ETA) receptor. With Kis of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 shows hypertensive effects[1].

    价 格：￥电议型 号：T14672产 地：中国大陆

  • T14665LMotixafortide TFA(664334-36-5,Free)；化合物Motixafortide TFATF 14016 TFA|||BKT140 TFA|||BL-8040 TFA|||T1

    Motixafortide TFA(664334-36-5,Free) (BKT140 TFA) is an antagonist of CXCR4 with IC50 of ～1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.

    价 格：￥电议型 号：T14665L产 地：中国大陆

  • T14642Bis-PEG5-acid；化合物 T14642PROTAC Linker 36；PROTAC Linker 36

    Bis-PEG5-acid (PROTAC Linker 36) is a polyethylene glycol (PEG) linker employed for the synthesis of CP5V, a PROTAC that selectively degrades Cdc20[1].

    价 格：￥电议型 号：T14642产 地：中国大陆

  • T14636Bis-PEG3-PFP ester；化合物 T14636Bis-PEG3-PFP ester

    Bis-PEG3-PFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

    价 格：￥电议型 号：T14636产 地：中国大陆

  • T14559BI 224436；化合物 T14559BI 224436

    BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.

    价 格：￥电议型 号：T14559产 地：中国大陆

  • T14536Benzyl-PEG2-Tos；化合物 T14536Benzyl-PEG2-Tos

    Benzyl-PEG2-Tos is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

    价 格：￥电议型 号：T14536产 地：中国大陆

  • T1452Axitinib；阿昔替尼AG-013736；AG-013736|||阿昔替尼|||阿西替尼

    Axitinib (AG-013736) is an orally bioavailable tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.7, 1.6 nM for VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFRβ, respectively.

    价 格：￥电议型 号：T1452产 地：中国大陆

  • T14436Azido-PEG3-Val-Cit-PAB-PNP；化合物 T14436Azido PEG3 Val Cit PAB PNP|||Azido-PEG3-Val-Cit-PAB-PNP|||Azido

    Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker employed for synthesizing antibody-drug conjugates (ADCs)[1]. It also serves as a PEG-based PROTAC linker for the synthesis of PROTACs[2].

    价 格：￥电议型 号：T14436产 地：中国大陆

  • T1439Lacidipine拉西地平SN-305|||拉西地平|||GX-1048|||GR-43659X

    Lacidipine (SN-305) is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does not lead to reflex tachycardia. It displays specificity in the vascular smooth muscle, where it acts as an antihypertensive agent to dilate peripheral arterioles and reduce blood pressure.

    价 格：￥电议型 号：T1439产 地：中国大陆

  • T14369AZD-0284；化合物AZD-0284AZD-0284

    AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].

    价 格：￥电议型 号：T14369产 地：中国大陆

  • T14368Azadirachtin B；印楝素 BAzadirachtin B

    Azadirachtin B, a limonoid derived from the seed kernels of Azadirachta indica, exhibits a broad spectrum of biochemical activities, including insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral, and osteogenic effects. It is effective against the Epstein-Barr virus early antigen (EBV-EA), enhances alkaline phosphatase (ALP) activity, and promotes osteoblast differentiation[1][2][3].

    价 格：￥电议型 号：T14368产 地：中国大陆

  • T14367AZ1495；化合物AZ1495AZ1495

    AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL).

    价 格：￥电议型 号：T14367产 地：中国大陆

  • T14366AZ10606120 dihydrochloride；化合物AZ10606120 dihydrochlorideAZ10606120 dihydrochloride

    AZ10606120 dihydrochloride is a selectable, potent, high-affinity receptor antagonist with K D values of 1.4 and 19 nM at human and rat P2X 7 receptors, respectively. AZ10606120 dihydrochloride inhibits tumor growth and has anti-angiogenic activity. AZ 10606120 acts as a negative allosteric modulator when bound to a site coupled to the ATP binding site.

    价 格：￥电议型 号：T14366产 地：中国大陆

  • T14365AZ PFKFB3 26；化合物AZ PFKFB3 26AZ PFKFB3 26

    AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.

    价 格：￥电议型 号：T14365产 地：中国大陆

  • T14364AZ-Dyrk1B-33；化合物T143643-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine；3-(2-Met

    AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.

    价 格：￥电议型 号：T14364产 地：中国大陆

  • T14363AZ-23；化合物AZ-23AZ 23|||AZ23；AZ 23|||AZ23

    AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.

    价 格：￥电议型 号：T14363产 地：中国大陆

  • T14362LAY 9944 dihydrochloride；化合物AY 9944 盐酸盐AY 9944 dihydrochloride

    AY 9944 dihydrochloride is a intermediate.

    价 格：￥电议型 号：T14362L产 地：中国大陆

  • T14362AY 9944；化合物AY 9944AY 9944

    AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol[1][2][3]. AY 9944 causes hypocholesterolemia and accumulation of 7DHC.

    价 格：￥电议型 号：T14362产 地：中国大陆

  • T14361Axomadol；阿索马多EN3324；阿索马多|||EN3324

    Axomadol (EN3324) is a centrally active analgesic compound. It has opioid agonistic properties and inhibitory effects on the reuptake of monoamines.

    价 格：￥电议型 号：T14361产 地：中国大陆

  • T14360AX-15836；化合物AX-15836AX-15836

    AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).

    价 格：￥电议型 号：T14360产 地：中国大陆

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