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  • T78942HSP90-IN-23；化合物 HSP90-IN-23HSP90-IN-23

    HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM. It promotes apoptosis in tumor cells and arrests their cell cycle at the G0/G1 phase, making it applicable for cancer research [1].

    价 格：￥电议型 号：T78942产 地：中国大陆

  • T78935Quorum Sensing-IN-2；化合物 Quorum Sensing-IN-2Quorum Sensing-IN-2

    Quorum Sensing-IN-2 (compound 23e) is a quorum sensing inhibitor that curtails bacterial pathogenicity without impeding growth. It demonstrates minimal hemolytic activity while effectively inhibiting bacterial infections and exhibits a synergistic effect when combined with Ciprofloxacin in a P. aeruginosa PAO1-infected bacteremia model [1].

    价 格：￥电议型 号：T78935产 地：中国大陆

  • T78907MAO-B-IN-22；化合物 MAO-B-IN-22MAO-B-IN-22

    MAO-B-IN-22 (compound 6h) represents a powerful MAO-B inhibitor, boasting an IC50 value of 0.014 μM, and exhibits high antioxidant activity alongside effective metal-chelating properties. It also demonstrates adequate BBB permeability and notable neuroprotective effects [1].

    价 格：￥电议型 号：T78907产 地：中国大陆

  • T78905AChE-IN-29；化合物 AChE-IN-29AChE-IN-29

    AChE-IN-29, a 3-OH pyrrolidine derivative, acts as a cholinesterase (ChE) inhibitor with potent activity against human acetylcholinesterase (hAChE), electric eel acetylcholinesterase (eeAChE), and equine butyrylcholinesterase (eqBChE), exhibiting IC50 values of 0.25 μM, 0.23 μM, and 0.72 μM, respectively. It is utilized in Alzheimer´s disease research [1].

    价 格：￥电议型 号：T78905产 地：中国大陆

  • T78898Lysyl hydroxylase 2-IN-2；化合物 Lysyl hydroxylase 2-IN-2Lysyl hydroxylase 2-IN-2

    Lysyl Hydroxylase 2-IN-2 (compound 13) is a potent inhibitor of Lysyl Hydroxylase 2 (LH2), exhibiting an IC50 of approximately 500 nM. It effectively inhibits cell migration in 344SQ WT cells without affecting the migration of LH2 knockout cells [1].

    价 格：￥电议型 号：T78898产 地：中国大陆

  • T78896SHP2-IN-22；化合物 SHP2-IN-22SHP2-IN-22

    SHP2-IN-22, a potent SHP2 allosteric inhibitor, exhibits an IC50 value of 17.7 nM and effectively suppresses proliferation, migration, and invasion in MIA PaCa-2 pancreatic cancer cells. This compound is utilized in the study of Kirsten rat sarcoma viral oncogene (KRAS) mutant cancer research [1].

    价 格：￥电议型 号：T78896产 地：中国大陆

  • T78894NLRP3-IN-21；化合物 NLRP3-IN-21NLRP3-IN-21

    NLRP3-IN-21 (compound L38) is an inhibitor of the NLRP3 inflammasome that possesses anti-inflammatory properties. It suppresses the activation of the NLRP3 inflammasome and pyroptosis by inhibiting gasdermin D cleavage, ASC oligomerization, and the assembly of the NLRP3 inflammasome [1].

    价 格：￥电议型 号：T78894产 地：中国大陆

  • T78892Glutaminase C-IN-2；化合物 Glutaminase C-IN-2Glutaminase C-IN-2

    Glutaminase C-IN-2 (compound 11), an allosteric inhibitor of glutaminase C (GAC), exhibits potent inhibitory activity with an IC50 of 10.64 nM. By disrupting glutamine metabolism, this compound modulates cellular metabolites and elevates reactive oxygen species (ROS), exerting anticancer effects [1].

    价 格：￥电议型 号：T78892产 地：中国大陆

  • T78887ROS-IN-2；化合物 ROS-IN-2ROS-IN-2

    ROS-IN-2 (compound 85), a seco-lupane triterpenoid derivative, inhibits reactive oxygen species (ROS) production and shields mitochondria from oxidative damage by curtailing the generation of oxidative stressors. It has applications in myocardial ischemia/reperfusion (MI/R) injury research [1].

    价 格：￥电议型 号：T78887产 地：中国大陆

  • T78879CXCR4-IN-2；化合物 CXCR4-IN-2CXCR4-IN-2

    CXCR4-IN-2 (compound A1), a potent bifunctional fluorinated small molecule, inhibits CXCR4 and exhibits anticancer properties by exerting cytotoxicity (IC 50: 60 μg/mL; 72 h) and antiproliferative effects on mouse colorectal cancer (CRC) cells. It induces G2/M phase cell cycle arrest and apoptosis [1].

    价 格：￥电议型 号：T78879产 地：中国大陆

  • T78869TWIK-1/TREK-1-IN-2；化合物 TWIK-1/TREK-1-IN-2TWIK-1/TREK-1-IN-2

    TWIK-1/TREK-1-IN-2 (Compound 2g) serves as an inhibitor of both TWIK-1 and TREK-1, targeting the TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50 values of 10.13 μM and 15.5 μM, respectively. Additionally, it exhibits antidepressant properties [1].

    价 格：￥电议型 号：T78869产 地：中国大陆

  • T78863HSP90-IN-25；化合物 HSP90-IN-25HSP90-IN-25

    HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].

    价 格：￥电议型 号：T78863产 地：中国大陆

  • T78860MAO-B-IN-24；化合物 MAO-B-IN-24MAO-B-IN-24

    MAO-B-IN-24 (compound 11h) is a selective, reversible, competitive inhibitor of MAO-B with an IC50 value of 1.60 μM. It also exhibits inhibitory effects on MAO-A with an IC50 of 22.42 μM. At a concentration of 10 μM, MAO-B-IN-24 reduces the activities of AChE and BChE to 54.58% and 88.43%, respectively [1].

    价 格：￥电议型 号：T78860产 地：中国大陆

  • T78859MAO-B-IN-23；化合物 MAO-B-IN-23MAO-B-IN-23

    MAO-B-IN-23, also known as Compound 11f, is a reversible and competitive monoamine oxidase B (MAO-B) inhibitor with an IC50 value of 1.44 μM and a Ki of 0.51 μM [1].

    价 格：￥电议型 号：T78859产 地：中国大陆

  • T78849EGFR/BRAFV600E-IN-2；化合物 EGFR/BRAFV600E-IN-2EGFR/BRAFV600E-IN-2

    E07 Aptamer, targeting the human epidermal growth factor receptor (hEGFR), competes with epidermal growth factor (EGF) for binding to a unique epitope on EGFR. This aptamer not only binds to EGFR-expressing cells but also inhibits receptor autophosphorylation and thwarts tumor cell proliferation in three-dimensional matrices, positioning it as a useful tool for tumor disease research [1].

    价 格：￥电议型 号：T78849产 地：中国大陆

  • T78844MET/PDGFRA-IN-2；化合物 MET/PDGFRA-IN-2MET/PDGFRA-IN-2

    MET/PDGFRA-IN-2 (compound 8h) serves as an inhibitor of MET and PDGFRA proteins, promoting apoptosis in cells and impeding the proliferation of MET-positive cells with IC50 values of 9.7, 6.1, 12.0, 11.5, 8.6, and 34.4 μM for AsPc-1, EBC-1, MKN-45, Mia-Paca-2, HT-29, and K562 cells, respectively [1].

    价 格：￥电议型 号：T78844产 地：中国大陆

  • T78801BRD7-IN-2；化合物 BRD7-IN-2BRD7-IN-2

    BRD7-IN-2 (compound 2-77) is a potent selective inhibitor of bromodomain-containing protein 7 (BRD7), exhibiting significant anti-proliferative activity in prostate cancer cells. It demonstrates an IC50 of 5.4 μM for BRD7 while showing weak inhibition for BRD9 with an IC50 of >300 μM.

    价 格：￥电议型 号：T78801产 地：中国大陆

  • T78787PARP-1/2-IN-2；化合物 PARP-1/2-IN-2PARP-1/2-IN-2

    PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair and inducing cell cycle arrest and apoptosis. This compound also hampers the proliferation of TNBC cells and the growth of TNBC xenograft tumors [1].

    价 格：￥电议型 号：T78787产 地：中国大陆

  • T78745Mtb-IN-2；Mtb抑制剂2Mtb-IN-2

    Mtb-IN-2 is a small molecule compound of Mycobacterium tuberculosis (Mtb) with antimicrobial activity and low toxicity that interferes with methionine metabolism processes and can be used to study tuberculosis.

    价 格：￥电议型 号：T78745产 地：中国大陆

  • T78744IRAK4-IN-24；化合物 IRAK4-IN-24IRAK4-IN-24

    IRAK4-IN-24 (compound 16), a potent IRAK4 inhibitor, exhibits high clearance (Cl) and low oral bioavailability. It is utilized in research pertaining to inflammatory and autoimmune disorders.

    价 格：￥电议型 号：T78744产 地：中国大陆

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