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  • T18722MAC glucuronide α-hydroxy lactone-linked SN-38；化合物 T18722MAC glucuronide α-hydroxy lactone-linked SN

    MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a cytotoxic drug linker that maintains a stabilized lactone form, showing efficacy against L540cy and Ramos cells, with IC50 values of 99 and 105 ng/mL, respectively[1].

    价 格：￥电议型 号：T18722产 地：中国大陆

  • T18699SNPB；化合物 T18699SNPB

    SNPB is a cleavable linker that is used for making antibody-drug conjugate (ADC).

    价 格：￥电议型 号：T18699产 地：中国大陆

  • T18698SNPB-sulfo-Me；化合物 T18698SNPB-sulfo-Me

    SNPB-sulfo-Me is a cleavable linker that is used for making antibody-drug conjugate (ADC).

    价 格：￥电议型 号：T18698产 地：中国大陆

  • T18697SNIPER(ER)-87；化合物 T18697SNIPER(ER)-87

    SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effectively degrades the ERα protein with an IC50 value of 0.097 μM. Within cells, SNIPER(ER)-87 selectively recruits XIAP to ERα, and XIAP functions as the primary E3 ubiquitin ligase responsible for the degradation of ERα induced by SNIPER(ER)-87[1][2].

    价 格：￥电议型 号：T18697产 地：中国大陆

  • T18696SNIPER(ER)-110；化合物 T18696SNIPER(ER)-110

    SNIPER(ER)-110 consists of a cIAP1 ligand and an estrogen ligand, connected by a linker. SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of <3 nM and 7.7 nM after 4 h and 48 h, respectively[1].

    价 格：￥电议型 号：T18696产 地：中国大陆

  • T18695SNIPER(ABL)-058；化合物 T18695SNIPER(ABL)-058

    SNIPER(ABL)-058, a compound that links Imatinib (ABL inhibitor) with a derivative of LCL161 (IAP ligand) through a linker, effectively decreases BCR-ABL protein levels, achieving a half-maximal degradation concentration (DC50) of 10 μM[1].

    价 格：￥电议型 号：T18695产 地：中国大陆

  • T18694SNIPER(ABL)-050；化合物 T18694SNIPER(ABL)-050

    SNIPER(ABL)-050 is a chemical compound that combines Imatinib, an ABL inhibitor, with MV-1, an IAP ligand, using a linker. This conjugation results in the reduction of BCR-ABL protein[1].

    价 格：￥电议型 号：T18694产 地：中国大陆

  • T18693SNIPER(ABL)-049；化合物 T18693SNIPER(ABL)-049

    SNIPER(ABL)-049, a compound that conjugates Imatinib (ABL inhibitor) with Bestatin (IAP ligand) through a linker, effectively reduces BCR-ABL protein levels, demonstrating a DC50 of 100 μM[1].

    价 格：￥电议型 号：T18693产 地：中国大陆

  • T18692SNIPER(ABL)-047；化合物 T18692SNIPER(ABL)-047

    SNIPER(ABL)-047, a compound that links HG-7-85-01 (an ABL inhibitor) to MV-1 (an IAP ligand) via a linker, effectively decreases the BCR-ABL protein levels, achieving a DC50 value of 2 μM[1].

    价 格：￥电议型 号：T18692产 地：中国大陆

  • T18691SNIPER(ABL)-044；化合物 T18691SNIPER(ABL)-044

    SNIPER(ABL)-044, a compound that links HG-7-85-01 (ABL inhibitor) to Bestatin (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, achieving a DC50 value of 10 μM[1].

    价 格：￥电议型 号：T18691产 地：中国大陆

  • T18689SNIPER(ABL)-033；化合物 T18689SNIPER(ABL)-033

    SNIPER(ABL)-033, a compound that conjugates HG-7-85-01 (ABL inhibitor) to a LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, exhibiting a DC50 of 0.3 μM[1].

    价 格：￥电议型 号：T18689产 地：中国大陆

  • T18687SNIPER(ABL)-020；化合物 T18687SNIPER(ABL)-020

    SNIPER(ABL)-020 is a chemical compound consisting of Dasatinib, an ABL inhibitor, and Bestatin, an IAP ligand, conjugated with a linker. This compound effectively reduces the BCR-ABL protein[1].

    价 格：￥电议型 号：T18687产 地：中国大陆

  • T18686SNIPER(ABL)-019；化合物 T18686SNIPER(ABL)-019

    SNIPER(ABL)-019, a compound that links Dasatinib (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, exhibiting a DC50 of 0.3 μM[1].

    价 格：￥电议型 号：T18686产 地：中国大陆

  • T18685SNIPER(ABL)-015；化合物 T18685SNIPER(ABL)-015

    SNIPER(ABL)-015, a compound that conjugates GNF5 (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels with a DC50 of 5 μM [1].

    价 格：￥电议型 号：T18685产 地：中国大陆

  • T18684SNIPER(ABL)-013；化合物 T18684SNIPER(ABL)-013

    SNIPER(ABL)-013, a compound that links GNF5 (ABL inhibitor) with Bestatin (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels with a DC50 of 20 μM[1].

    价 格：￥电议型 号：T18684产 地：中国大陆

  • T18538MAC glucuronide phenol-linked SN-38；化合物 T18538MAC glucuronide phenol-linked SN-38

    MAC glucuronide phenol-linked SN-38, a pH-sensitive lactone and DNA topoisomerase I inhibitor drug linker, exhibits cytotoxicity in L540cy and Ramos cells, with IC50 values of 113 ng/mL and 67 ng/mL, respectively[1].

    价 格：￥电议型 号：T18538产 地：中国大陆

  • T17946Fmoc-Ala-Ala-Asn(Trt)-OH；化合物Fmoc-Ala-Ala-Asn(Trt)-OHFmoc-Ala-Ala-Asn(Trt)-OH

    Fmoc-Ala-Ala-Asn(Trt)-OH is a cleavable linker vital in ADC synthesis. Fmoc-Ala-Ala-Asn(Trt)-OH joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

    价 格：￥电议型 号：T17946产 地：中国大陆

  • T17945Fmoc-Ala-Ala-Asn-PABC-PNP；化合物 T17945FmocAlaAlaAsnPABCPNP|||Fmoc-Ala-Ala-Asn-PABC-PNP|||Fmoc Ala Ala

    Fmoc-Ala-Ala-Asn-PABC-PNP is a peptide cleavable ADC linker[1].

    价 格：￥电议型 号：T17945产 地：中国大陆

  • T17731LCL2A-SN-38 DCA 1279680-68-0(free base)；化合物CL2A-SN-38 DCACL2A-SN-38 DCA 1279680-68-0(free base)

    CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC).. CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a noncleavable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable t

    价 格：￥电议型 号：T17731L产 地：中国大陆

  • T17731CL2A-SN-38；化合物CL2A-SN-38CL2A|||CL2A SN 38|||bystander effect|||SN-38|||antitumor|||CL2A-SN-38|||Inhi

    CL2A-SN-38 is a drug-linker conjugate consisting of SN-38, a potent DNA topoisomerase I inhibitor, and linker CL2A, for the manufacture of antibody drug conjugates (ADCs). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a nonclaevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulf

    价 格：￥电议型 号：T17731产 地：中国大陆

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