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T17365Ala-Ala-Asn-PAB;化合物 T17365Ala-Ala-Asn-PAB
Ala-Ala-Asn-PAB is a peptide cleavable ADC linker for antibody-drug conjugates (ADCs)[1].
价 格:¥电议型 号:T17365产 地:中国大陆
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T17220Vecabrutinib;维卡布鲁替尼SNS-062;SNS-062
Vecabrutinib (SNS-062) is a potent and noncovalent BTK and ITK inhibitor (Kd: 0.3 nM and 2.2 nM, respectively). Vecabrutinib displays an IC50 of 24 nM for ITK.
价 格:¥电议型 号:T17220产 地:中国大陆
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T17069THAL-SNS-032;化合物THAL-SNS-032THAL-SNS-032
THAL-SNS-032 is a selective CDK9 degrader PROTAC.
价 格:¥电议型 号:T17069产 地:中国大陆
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T1703SN-38;伊立替康杂质BNK012|||SN 38;7-乙基-10-羟基喜树碱|||NK012|||伊立替康杂质B|||SN 38
SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM). SN-38 has antitumor activity and induces autophagy.
价 格:¥电议型 号:T1703产 地:中国大陆
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T16905SNIPER(BRD)-1;化合物 T16905SNIPER(BRD)-1
SNIPER(BRD)-1 is a chemical compound composed of a derivative of the IAP antagonist LCL-161 and the BET inhibitor (+)-JQ-1, linked together. It promotes the degradation of BRD4 through the ubiquitin-proteasome pathway and effectively degrades cIAP1, cIAP2, and XIAP with IC50 values of 6.8 nM, 17 nM, and 49nM, respectively[1].
价 格:¥电议型 号:T16905产 地:中国大陆
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T16831(S)-SNAP5114;化合物(S)-SNAP5114(S)-SNAP5114
(S)-SNAP5114 is a selective inhibitor of GABA transport with IC50s of 5 μM for hGAT-3 and 21 μM for rGAT-2. (S)-SNAP5114 has anticonvulsant properties.
价 格:¥电议型 号:T16831产 地:中国大陆
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T1672Dimesna;地美司钠BNP-7787;地美司钠|||BNP-7787
Dimesna (BNP-7787) is a synthetic derivative of dithio-ethane sulfonate with uroprotective properties.
价 格:¥电议型 号:T1672产 地:中国大陆
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T16678PSN632408;化合物 T16678PSN632408
PSN632408 is an optimized agonist of GPR119 receptors that display similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50: 5.6 and 7.9 uM, respectively).
价 格:¥电议型 号:T16678产 地:中国大陆
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T16155MSN-125;化合物 T16155MSN-125
MSN-125 effectively inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons protect primary neurons against glutamate excitotoxicity. MSN-125 is an effective Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) (IC50: 4 μM).
价 格:¥电议型 号:T16155产 地:中国大陆
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T15688L-771688;化合物L-771688SNAP 6383;SNAP 6383
L-771688 (SNAP 6383) is a novel potent and selective α1A-adrenoceptor antagonist with a Ki value of 0.43±0.02 nM.L-771688 KE is used for the treatment of benign prostatic hyperplasia.
价 格:¥电议型 号:T15688产 地:中国大陆
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T15341Fosnetupitant;化合物 T15341Pronetupitant;Pronetupitant
Fosnetupitant is a methylene phosphate prodrug of Netupitant. It has a pKi of 9.5 for the human NK1 receptor.
价 格:¥电议型 号:T15341产 地:中国大陆
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T15331Fmoc-PEG4-Ala-Ala-Asn-PAB;化合物 T15331Fmoc-PEG4-Ala-Ala-Asn-PAB
Fmoc-PEG4-Ala-Ala-Asn-PAB is a four-unit polyethylene glycol (PEG) linker, cleavable in nature. It is specifically employed for the synthesis of antibody-drug conjugates (ADCs)[1].
价 格:¥电议型 号:T15331产 地:中国大陆
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T15329Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB;化合物 T15329Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB
Fmoc-PEG3-Ala-Ala-Asn(Trt)-PAB is a cleavable three-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].
价 格:¥电议型 号:T15329产 地:中国大陆
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T15281Fidarestat;化合物 T15281SNK 860;SNK 860
Fidarestat is an aldose reductase inhibitor (IC50s: 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10, and V301L AKR1B10, respectively). It has the potential to treat diabetic disease.
价 格:¥电议型 号:T15281产 地:中国大陆
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T15278Fezolinetant;化合物FezolinetantESN-364;ESN-364
Fezolinetant (ESN-364) is an antagonist of the neurokinin 3 receptor (NK3R). It is used for the treatment of menopausal hot flushes.
价 格:¥电议型 号:T15278产 地:中国大陆
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T15271Denifanstat;化合物FASN-IN-2FASN-IN-2|||TVB2640|||TVB-2640;FASN-IN-2|||TVB2640|||TVB-2640
Denifanstat (FASN-IN-2) is a Fatty Acid Synthase (FASN) inhibitor(IC50 of 0.052 μM and an EC50 of 0.072 μM),with potential antineoplastic activity.
价 格:¥电议型 号:T15271产 地:中国大陆
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T1478Ondansetron hydrochloride dihydrate;盐酸昂丹司琼SN 307|||NSC 665799|||GR 38032|||Ondansetron hydrochloride
Ondansetron hydrochloride dihydrate (GR 38032) is a competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
价 格:¥电议型 号:T1478产 地:中国大陆
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T1476Pramipexole;普拉克索SND 919;SND 919|||普拉克索
Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not been implicated in cases of clinically apparent acute liver injury.
价 格:¥电议型 号:T1476产 地:中国大陆
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T14455Azido-PEG5-Ala-Ala-Asn-PAB;化合物 T14455Azido-PEG5-Ala-Ala-Asn-PAB
Azido-PEG5-Ala-Ala-Asn-PAB is a cleavable 5-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].
价 格:¥电议型 号:T14455产 地:中国大陆
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T1439Lacidipine拉西地平SN-305|||拉西地平|||GX-1048|||GR-43659X
Lacidipine (SN-305) is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does not lead to reflex tachycardia. It displays specificity in the vascular smooth muscle, where it acts as an antihypertensive agent to dilate peripheral arterioles and reduce blood pressure.
价 格:¥电议型 号:T1439产 地:中国大陆