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T76656Pseudin-2;化合物 Pseudin-2Pseudin-2
Pseudin-2, an antimicrobial peptide (AMP) isolated from the skin of the South American paradoxical frog (Pseudis paradoxa), demonstrates a potent inhibitory effect on the growth of Gram-negative bacteria [1].
价 格:¥电议型 号:T76656产 地:中国大陆
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T76585Hepcidin-20 (human);化合物 Hepcidin-20 (human)Hepcidin-20 (human)
Hepcidin-20 (human), a peptide characterized by its histidine content, cysteine-rich composition, and β-sheet structure, exhibits antifungal properties. Furthermore, it effectively inhibits biofilm formation and disrupts the metabolism of bacterial cells in both polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains [1] [2] [3].
价 格:¥电议型 号:T76585产 地:中国大陆
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T76460Tyr-Somatostatin-28;化合物 Tyr-Somatostatin-28Tyr-Somatostatin-28
Tyr-Somatostatin-28 is a somatostatin derivative consisting of Somatostatin-28 with an additional Tyrosine amino acid [1].
价 格:¥电议型 号:T76460产 地:中国大陆
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T76414PRMT5-IN-23;化合物 PRMT5-IN-23PRMT5-IN-23
PRMT5-IN-23 (compound 50), an inhibitor of protein arginine methyltransferase 5 (PRMT5), exhibits anti-tumor activity. As a novel anti-tumor target associated with epigenetic modification, PRMT5 belongs to the protein arginine methyltransferase family [1].
价 格:¥电议型 号:T76414产 地:中国大陆
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T76413PRMT5-IN-22;化合物 PRMT5-IN-22PRMT5-IN-22
PRMT5-IN-22 (compound 53), an inhibitor of protein arginine methyltransferase 5 (PRMT5), exhibits anti-tumor activity. As a protein arginine methyltransferase, PRMT5 represents a novel anti-tumor target associated with epigenetic modification [1].
价 格:¥电议型 号:T76413产 地:中国大陆
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T76271Hepcidin-25 (human);化合物 Hepcidin-25 (human)Hepcidin-25 (human)
Hepcidin-25 (human), an iron metabolism modulator, exhibits both anti-inflammatory and antibacterial activity through the modulation of iron-mediated oxidant injury [1].
价 格:¥电议型 号:T76271产 地:中国大陆
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T75883Agitoxin-2 TFA;化合物 Agitoxin-2 TFAAgitoxin-2 TFA
Agitoxin-2 TFA, a potent inhibitor of K+ channels, exhibits IC50 values of 201 pM and 144 pM for mK V 1.3 and mK V 1.1, respectively [1] [2].
价 格:¥电议型 号:T75883产 地:中国大陆
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T75633(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid;化合物 (22S,24E)-3β,22-Diacetoxylanosta-7
(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid (compound 15) serves as an antitubercular agent, displaying a minimum inhibitory concentration (MIC) of 12.5 μg/mL against Mycobacterium tuberculosis H37Ra. Additionally, this compound demonstrates cytotoxicity towards Vero cells with an IC50 value of 32 μM [1].
价 格:¥电议型 号:T75633产 地:中国大陆
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T75612α-Glucosidase-IN-24;化合物 α-Glucosidase-IN-24α-Glucosidase-IN-24
α-Glucosidase-IN-24 (Compound 13), an α-Glucosidase inhibitor, exhibits an IC50 value of 451 μM and can be derived from Swertia kouitchensis [1].
价 格:¥电议型 号:T75612产 地:中国大陆
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T75572Obtusifolin-2-O-glucoside;化合物 Obtusifolin-2-O-glucosideObtusifolin-2-O-glucoside
Obtusifolin-2-O-glucoside (compound 7), a tyrosinase inhibitor with an IC50 value of 9.2 μM, can be isolated from cassia seed [1].
价 格:¥电议型 号:T75572产 地:中国大陆
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T75254P2X7-IN-2 TFA;化合物 P2X7-IN-2 TFAP2X7-IN-2 TFA
P2X7-IN-2 TFA (compound 58) is a P2X7 receptor inhibitor that demonstrates the capability to inhibit IL-Iβ release effectively with an IC50 value of 0.01 nM. It is utilized in research focused on autoimmunity, inflammation, and cardiovascular disease [1].
价 格:¥电议型 号:T75254产 地:中国大陆
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T75142Acid Ceramidase-IN-2;化合物 Acid Ceramidase-IN-2Acid Ceramidase-IN-2
Acid Ceramidase-IN-2 (compound 1), an acid ceramidase inhibitor, exhibits potentially antiproliferative and cytostatic effects. This compound is of interest due to the overexpression of human acid ceramidase in prostate cancer cells, suggesting its potential anti-tumor efficacy. Furthermore, the hydrolysis of Acid Ceramidase-IN-2 can be inhibited by 3 a-ketoamides: GT85, GT98, and GT99 in vitro [1].
价 格:¥电议型 号:T75142产 地:中国大陆
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T75124BTK-IN-24;化合物 BTK-IN-24BTK-IN-24
BTK-IN-24 (compound 195) is a potent BTK inhibitor via a ubiquitin proteolytic pathway [1] .
价 格:¥电议型 号:T75124产 地:中国大陆
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T75121CDK7-IN-21;化合物 CDK7-IN-21CDK7-IN-21
CDK7-IN-21 (compound A22) is a potent CDK7 inhibitor [1] .
价 格:¥电议型 号:T75121产 地:中国大陆
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T75119KRASG12Cu00A0IN-2;化合物 KRASG12Cu00A0IN-2KRASG12Cu00A0IN-2
KRASG12C IN-2 (compound 17) is an orally active inhibitor of KRAS G12C, which effectively suppresses tumor growth in mice [1].
价 格:¥电议型 号:T75119产 地:中国大陆
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T750476-Amino-3-(furan-2-yl)-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine;化合物 6-Amino-3-(f
6-Amino-3-(furan-2-yl)-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine, a purine nucleoside analogue, exhibits broad antitumor activity by targeting indolent lymphoid malignancies. Its anticancer mechanisms include inhibition of DNA synthesis and induction of apoptosis.
价 格:¥电议型 号:T75047产 地:中国大陆
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T7504Necrostatin 2 racemate;化合物Necrostatin 2 racemateNecrostatin-2 racemate;5-[(7-氯-1H-吲哚-3-基)甲基]-3-甲基-2,
Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.
价 格:¥电议型 号:T7504产 地:中国大陆
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T75030Ubiquitination-IN-2;化合物 Ubiquitination-IN-2Ubiquitination-IN-2
Ubiquitination-IN-2 is a potent inhibitor of E1-E2 protein?protein interactions (PPI), displaying inhibitory activity with a dissociation constant (Kd) of 0.72 μM for the ubiquitin E1 (Uba1) enzyme. By blocking the transfer of ubiquitin from E1 to E2, Ubiquitination-IN-2 serves as a valuable tool in cancer research [1].
价 格:¥电议型 号:T75030产 地:中国大陆
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T75004TGFβ1-IN-2;TGFβ1抑制剂2TGFβ1-IN-2
TGFβ1-IN-2, a derivative of diarylacylhydrazones, effectively inhibits fibroblast activation and proliferation and holds potential for idiopathic pulmonary fibrosis (IPF) research [1].
价 格:¥电议型 号:T75004产 地:中国大陆
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T74947LSARS-CoV-2-IN-29 disodium;化合物 SARS-CoV-2-IN-29 disodiumSARS-CoV-2-IN-29 disodium
SARS-CoV-2-IN-29 disodium, a diphosphate ester featuring a benzene system and molecular tweezers architecture, demonstrates antiviral efficacy by targeting SARS-CoV-2 with half-maximal inhibitory concentrations (IC50s) of 1.5 μM for virus activity and 1.6 μM for spike pseudoparticle transduction. Additionally, it disrupts liposomal membranes, evidenced by a half-maximal effective concentration (EC50) of 3.0 μM [1].
价 格:¥电议型 号:T74947L产 地:中国大陆