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T74947SARS-CoV-2-IN-29；化合物 SARS-CoV-2-IN-29SARS-CoV-2-IN-29
SARS-CoV-2-IN-29, a two-armed diphosphate ester featuring a benzene system and molecular tweezers, demonstrates antiviral efficacy with IC50 values of 1.5 μM for SARS-CoV-2 activity and 1.6 μM against spike pseudoparticle transduction. Additionally, it disrupts liposomal membranes, as indicated by an EC50 of 3.0 μM [1].
价 格：￥电议型 号：T74947产 地：中国大陆
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T74946LSARS-CoV-2-IN-28 disodium；化合物 SARS-CoV-2-IN-28 disodiumSARS-CoV-2-IN-28 disodium
SARS-CoV-2-IN-28 disodium, a diphosphate ester featuring a C7 alkyl chain and extended-length molecular tweezers, demonstrates antiviral efficacy by showing IC50 values of 0.4 μM and 1.0 μM against SARS-CoV-2 activity and spike pseudoparticle transduction, respectively. Additionally, it disrupts liposomal membranes with an EC50 of 4.4 μM [1].
价 格：￥电议型 号：T74946L产 地：中国大陆
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T74946SARS-CoV-2-IN-28；化合物 SARS-CoV-2-IN-28SARS-CoV-2-IN-28
SARS-CoV-2-IN-28, a two-armed diphosphate ester featuring a C7 alkyl chain and molecular tweezers of extended length, demonstrates antiviral properties by exhibiting IC 50 values of 0.4 μM against SARS-CoV-2 activity and 1.0 μM against spike pseudoparticle transduction. Additionally, it disrupts liposomal membranes, evidenced by an EC 50 value of 4.4 μM [1].
价 格：￥电议型 号：T74946产 地：中国大陆
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T74945LSARS-CoV-2-IN-27 disodium；化合物 SARS-CoV-2-IN-27 disodiumSARS-CoV-2-IN-27 disodium
SARS-CoV-2-IN-27 disodium, a diphosphate ester featuring a C6 alkyl chain and molecular tweezers of extended length, demonstrates antiviral efficacy by achieving IC50 values of 1.0 μM against SARS-CoV-2 activity and 1.7 μM for spike pseudoparticle transduction. Additionally, it disrupts liposomal membranes, displaying an EC50 value of 6.5 μM [1].
价 格：￥电议型 号：T74945L产 地：中国大陆
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T74945SARS-CoV-2-IN-27；化合物 SARS-CoV-2-IN-27SARS-CoV-2-IN-27
SARS-CoV-2-IN-27, a diphosphate ester featuring a C6 alkyl chain and extended-length molecular tweezers, demonstrates antiviral efficacy, with IC50 values of 1.0 μM and 1.7 μM against SARS-CoV-2 activity and spike pseudoparticle transduction, respectively. Additionally, it disrupts liposomal membranes, evidenced by an EC50 of 6.5 μM [1].
价 格：￥电议型 号：T74945产 地：中国大陆
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T74944LSARS-CoV-2-IN-23 disodium；化合物 SARS-CoV-2-IN-23 disodiumSARS-CoV-2-IN-23 disodium
SARS-CoV-2-IN-23 disodium, a medium-length molecular tweezer and two-armed diphosphate ester, demonstrates antiviral properties by inhibiting SARS-CoV-2 activity and spike pseudoparticle transduction with IC50 values of 8.2 μM and 2.6 μM, respectively. Additionally, it disrupts liposomal membranes with an EC50 of 4.4 μM [1].
价 格：￥电议型 号：T74944L产 地：中国大陆
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T74944SARS-CoV-2-IN-26；化合物 SARS-CoV-2-IN-26SARS-CoV-2-IN-26
SARS-CoV-2-IN-23, a two-armed diphosphate ester and medium-length molecular tweezers, displays antiviral properties, demonstrating IC50 values of 8.2 μM against SARS-CoV-2 activity and 2.6 μM for spike pseudoparticle transduction. Additionally, it induces liposomal membrane disruption with an EC50 value of 4.4 μM [1].
价 格：￥电议型 号：T74944产 地：中国大陆
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T74943LSARS-CoV-2-IN-25 disodium；化合物 SARS-CoV-2-IN-25 disodiumSARS-CoV-2-IN-25 disodium
SARS-CoV-2-IN-25 (Compound CP026) disodium, a potent inhibitor of SARS-CoV-2 spike pseudoparticle transduction, demonstrates significant efficacy with an IC50 value of 1.6 μM. Additionally, it effectively inhibits enveloped viruses and liposomes, showcasing its broad-spectrum antiviral potential.
价 格：￥电议型 号：T74943L产 地：中国大陆
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T74943SARS-CoV-2-IN-25；化合物 SARS-CoV-2-IN-25SARS-CoV-2-IN-25
SARS-CoV-2-IN-25 (Compound CP026) is a potent inhibitor, specifically targeting the transduction of SARS-CoV-2 spike pseudoparticles, with an inhibitory concentration (IC50) of 1.6 μM. It effectively inhibits enveloped viruses and liposomes [1].
价 格：￥电议型 号：T74943产 地：中国大陆
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T74935MDM2/4-p53-IN-2；化合物 MDM2/4-p53-IN-2MDM2/4-p53-IN-2
MDM2/4-p53-IN-2 (2q) is a potent dual inhibitor of MDM2/MDM4 and activator of p53, demonstrating IC50 values of 70.7 nM for MDM2-p53 and 81.4 nM for MDM4-p53 complexes. It facilitates cell cycle regulation, promotes apoptosis, and exhibits anticancer properties [1].
价 格：￥电议型 号：T74935产 地：中国大陆
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T74933Trypanothione synthetase-IN-2；化合物 Trypanothione synthetase-IN-2Trypanothione synthetase-IN-2
Trypanothione Synthetase-IN-2 (Compound 3) functions as a competitive inhibitor of Leishmania infantum trypanothione synthetase (TryS), demonstrating an inhibition constant (IC50) of 5.4 μM in the presence of the polyamine S, triamine spermidine [1].
价 格：￥电议型 号：T74933产 地：中国大陆
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T74860MAO-B-IN-21；化合物 MAO-B-IN-21MAO-B-IN-21
MAO-B-IN-21 is an MAO-B inhibitor characterized by superior antioxidant and anti-Aβ aggregation activities. The compound additionally shows metal-ion chelating capabilities, mitigates neuroinflammation (NO, TNF-α), and demonstrates neuroprotective effects with notable BBB permeability. In an Aβ1-42 induced Alzheimer´s disease mouse model, MAO-B-IN-21 markedly enhances memory and cognitive functions [1].
价 格：￥电议型 号：T74860产 地：中国大陆
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T74858LSD1-IN-26；化合物 LSD1-IN-26LSD1-IN-26
LSD1-IN-26 (compound 12u), a potent LSD1 inhibitor, exhibits an IC50 of 25.3 nM. It also demonstrates inhibition of MAO-A (IC50 = 1234.57 nM) and MAO-B (IC50 = 3819.27 nM), significantly inducing apoptosis in MGC-803 cells. This compound is applicable in gastric cancer research [1].
价 格：￥电议型 号：T74858产 地：中国大陆
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T74855LSD1-IN-25；化合物 LSD1-IN-25LSD1-IN-25
LSD1-IN-25 (Compound 9j) is a potent, selective, and orally active inhibitor of LSD1, exhibiting an IC50 of 46 nM (Ki = 30.3 nM) and capable of inducing apoptosis in cancer cells [1].
价 格：￥电议型 号：T74855产 地：中国大陆
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T74835MTHFD2-IN-2；化合物 MTHFD2-IN-2MTHFD2-IN-2
MTHFD2-IN-2 (compound 13) serves as a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].
价 格：￥电议型 号：T74835产 地：中国大陆
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T74833EGFR T790M/L858R-IN-2；化合物 EGFR T790M/L858R-IN-2EGFR T790M/L858R-IN-2
EGFRT790M/L858R-IN-2 is a potent, selective inhibitor of EGFRT790M/L858R, exhibiting IC50 values of 3.5 nM for EGFRT790M/L858R and 1290 nM for EGFR WT. This compound effectively decreases the expression of p-EGFR, P-AKT, P-ERK1/2, and induces apoptosis as well as cell cycle arrest in the G1 phase, demonstrating anti-cancer activity [1].
价 格：￥电议型 号：T74833产 地：中国大陆
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T74827AcrB-IN-2；化合物 AcrB-IN-2AcrB-IN-2
Efflux pump-IN-2 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics . Efflux pump-IN-2 inhibits Nile Red (a known substrate of AcrB) efflux. Efflux pump-IN-2 does not disrupts the bacterial outer membrane nor display toxicity in a nematode model [1] .
价 格：￥电议型 号：T74827产 地：中国大陆
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T74823Bromodomain IN-2；化合物 Bromodomain IN-2Bromodomain IN-2
BD-IN-1, a pan bromodomain (BD) inhibitor, exhibits K_D values of 250 nM for BRD4(1), 420 nM for CBP, 130 nM for BRPF1B, 430 nM for BRD7, 67 nM for BRD9, 240 nM for BRDT(1), and 970 nM for CECR2, respectively. This compound demonstrates antiproliferative activity [1].
价 格：￥电议型 号：T74823产 地：中国大陆
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T74815SLC26A3-IN-2；化合物 SLC26A3-IN-2SLC26A3-IN-2
SLC26A3-IN-2 is an orally active compound that functions as an inhibitor of the anion exchanger protein SLC26A3, displaying an IC50 of 360 nM. This protein is a member of the solute carrier (SLC) family, specifically the SLC26 family, known for its broad anion specificity, including chloride, bicarbonate, sulfate, and oxalate. SLC26A3, also known as DRA, is typically down-regulated in adenoma and plays a crucial role in the intestinal absorption of chloride and oxalate. Moreover, mutations resul
价 格：￥电议型 号：T74815产 地：中国大陆
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T74797MAO-B-IN-20；化合物 MAO-B-IN-20MAO-B-IN-20
MAO-B-IN-20 (Compound C14), a potent MAO-B inhibitor boasting an IC50 of 0.037 μM, demonstrates excellent metabolic stability and brain-blood barrier permeability. It holds potential for Parkinson´s disease research [1].
价 格：￥电议型 号：T74797产 地：中国大陆
