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  • T74792USP28-IN-2；化合物 USP28-IN-2USP28-IN-2

    USP28-IN-2 is a selective USP28 inhibitor (IC50 = 0.3 μM), demonstrating high specificity compared to USP2, USP7, USP8, USP9x, UCHL3, and UCHL5. This compound exhibits cytotoxic effects on cancer cells and induces the degradation of c-Myc via the ubiquitin-proteasome pathway. Additionally, USP28-IN-2 reduces ankyrin-1/2 levels in vitro and potentiates the responsiveness of colorectal cancer cells to Regorafenib [1].

    价 格：￥电议型 号：T74792产 地：中国大陆

  • T74756SDH-IN-2；SDH抑制剂2SDH-IN-2

    SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.55 μg/mL.SDH-IN-2 possesses antifungal activity, with average EC50 values of 3.82-9.81 μg/mL for inhibition of plant pathogenic fungi.

    价 格：￥电议型 号：T74756产 地：中国大陆

  • T74712TMV-IN-2；化合物 TMV-IN-2TMV-IN-2

    TMV-IN-2, a chalcone derivative, functions as an inhibitor of the tobacco mosaic virus (TMV), exhibiting antiviral properties with an EC50 of 89.9 μg/mL. This compound is utilized in investigating infection, inflammation, and tumor research [1].

    价 格：￥电议型 号：T74712产 地：中国大陆

  • T74671ROS kinases-IN-2；ROS 激酶抑制剂2ROS kinases-IN-2

    ROS kinases-IN-2 is a potent ROS kinase inhibitor with an inhibition rate of 21.53% measured at 10 μM.ROS kinases-IN-2 has potential anticancer activity and can be used to study abnormal cell growth.

    价 格：￥电议型 号：T74671产 地：中国大陆

  • T74631RNA polymerase II-IN-2；化合物 RNA polymerase II-IN-2RNA polymerase II-IN-2

    RNA polymerase II-IN-2 (compound 20iii), a potent inhibitor of RNA polymerase II (Pol II) with a K i value of 9.5 nM, demonstrates cytotoxicity against cancer cells, exhibiting toxicity levels 2 and 5 times higher than α-amanitin in CHO and HEK293 cells, respectively [1].

    价 格：￥电议型 号：T74631产 地：中国大陆

  • T74612Aminoacyl tRNA synthetase-IN-2；化合物 Aminoacyl tRNA synthetase-IN-2Aminoacyl tRNA synthetase-IN-2

    Aminoacyl tRNA Synthetase-IN-2 (Compound 14) serves as an inhibitor of aminoacyl-tRNA synthetase (aaRS), presenting potential for the formulation of a novel class of antibiotics [1].

    价 格：￥电议型 号：T74612产 地：中国大陆

  • T74572RIPK2-IN-2；化合物 RIPK2-IN-2RIPK2-IN-2

    RIPK2-IN-2 (example 25) is a RIP2 kinase PROTAC inhibitor that effectively blocks RIP2-dependent proinflammatory signaling and regulates RIP2 kinase activity in autoinflammatory diseases [1].

    价 格：￥电议型 号：T74572产 地：中国大陆

  • T74536IDO/Tubulin-IN-2；化合物 IDO/Tubulin-IN-2IDO/Tubulin-IN-2

    IDO/Tubulin-IN-2 (HT2) is a powerful inhibitor of both TDO and tubulin. This compound demonstrates significant efficacy against various cancer cell lines, including U87, HepG2, A549, HCT-116, and LO2, with respective IC50 values of 0.43, 0.036, 0.041, 0.095, and 1.04 μM. Additionally, IDO/Tubulin-IN-2 markedly enhances antitumor activity [1].

    价 格：￥电议型 号：T74536产 地：中国大陆

  • T74522ALK-IN-21；化合物 ALK-IN-21ALK-IN-21

    ALK-IN-21 (Compound B10), a proficient ALK inhibitor targeting the ALKG1202R mutation, demonstrates significant inhibitory activity, with IC50 values of 4.59 nM against ALK WT, 2.07 nM against ALK L1196M, and 5.95 nM against ALK G1202R. Moreover, ALK-IN-21 effectively suppresses proliferation in ALK-positive Karpas299 and H2228 cells, achieving IC50 values of 0.07 μM. It is applicable for anaplastic large cell lymphoma research [1].

    价 格：￥电议型 号：T74522产 地：中国大陆

  • T74507IDO1-IN-20；化合物 IDO1-IN-20IDO1-IN-20

    IDO1-IN-20 is an enzyme that catalyzes the oxidative metabolism of tryptophan. It can immunosuppress tumors in the tumor microenvironment.

    价 格：￥电议型 号：T74507产 地：中国大陆

  • T74361MEK/PI3K-IN-2；化合物 MEK/PI3K-IN-2MEK/PI3K-IN-2

    MEK/PI3K-IN-2 (compound 6s), a potent inhibitor of both MEK and PI3K, demonstrates IC50 values of 352 nM (MEK1), 107 nM (PI3Kα), and 137 nM (PI3Kδ). This compound effectively reduces pAKT and pERK1/2 levels, exhibiting anti-proliferative activity against various tumor cell lines [1].

    价 格：￥电议型 号：T74361产 地：中国大陆

  • T74295Cap-dependent endonuclease-IN-22；化合物 Cap-dependent endonuclease-IN-22Cap-dependent endonuclease-IN-2

    Cap-dependent endonuclease-IN-22 is a powerful inhibitor of cap-dependent endonuclease (CEN) [1].

    价 格：￥电议型 号：T74295产 地：中国大陆

  • T74282HIV-IN-2；化合物 HIV-IN-2HIV-IN-2

    HIV-IN-2 (Compound 100) is a potent inhibitor of HIV, showing potential for research into HIV infection [1].

    价 格：￥电议型 号：T74282产 地：中国大陆

  • T74271TRIM24/BRPF1-IN-2；化合物 TRIM24/BRPF1-IN-2TRIM24/BRPF1-IN-2

    TRIM24/BRPF1-IN-2 (compound 20l) is an effective dual inhibitor of TRIM24/BRPF1, demonstrating IC50 values of 0.98 μM for TRIM24 and 1.16 μM for BRPF1, respectively. It exhibits strong binding affinity to the bromodomains of TRIM24/BRPF1, making it a valuable tool for prostate cancer research [1].

    价 格：￥电议型 号：T74271产 地：中国大陆

  • T74249AS(3n-2)-Inclisiran；化合物 AS(3n-2)-InclisiranAS(3n-2)-Inclisiran

    Inclisiran AS(3n-2), an antisense variant of Inclisiran, features a 2 bp spacer followed by 3 random N sites. Inclisiran itself is a double-stranded small interfering RNA (siRNA) molecule designed to suppress PCSK-9 transcription, thereby reducing LDL cholesterol levels [1].

    价 格：￥电议型 号：T74249产 地：中国大陆

  • T74215EGFR-IN-22；化合物 EGFR-IN-22EGFR-IN-22

    EGFR-IN-22 is a highly effective inhibitor targeting wild type EGFR and its mutant form, EGFR L858R/T790M/C797S, displaying IC50 values of 4.91 nM and 0.54 nM, respectively.

    价 格：￥电议型 号：T74215产 地：中国大陆

  • T74003HDAC3/6-IN-2；化合物 HDAC3/6-IN-2HDAC3/6-IN-2

    HDAC3/6-IN-2 (compound 15) is a dual inhibitor targeting HDAC6 and HDAC3, exhibiting potent activity with IC50 values of 0.368 μM for HDAC6 and 0.635 μM for HDAC3. This compound demonstrates antitumor effects by inducing apoptosis in cancer cells and reducing HDAC6 and HDAC3 levels. This action is linked to the increased acetylation of H3 and α-tubulin [1].

    价 格：￥电议型 号：T74003产 地：中国大陆

  • T73921Ep300/CREBBP-IN-2；化合物 Ep300/CREBBP-IN-2Ep300/CREBBP-IN-2

    Ep300/CREBBP-IN-2 (Example 73), a powerful and orally bioavailable inhibitor targeting Ep300 and CREBBP, demonstrates IC50 values of 0.052 μM and 0.148 μM, respectively. This compound is employed in cancer research [1].

    价 格：￥电议型 号：T73921产 地：中国大陆

  • T73834NS5A-IN-2；化合物 NS5A-IN-2NS5A-IN-2

    NS5A-IN-2 (Compound 33) serves as a potent NS5A inhibitor exhibiting exceptional efficacy against HCV genotype 1b, enhanced activity against genotype 3a (GT 3a), and notable metabolic stability [1].

    价 格：￥电议型 号：T73834产 地：中国大陆

  • T7368IRAK inhibitor 2IRAK抑制剂2IRAK-IN-2

    IRAK inhibitor 2 (IRAK-IN-2) is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK-4) for the study of inflammation-related diseases.

    价 格：￥电议型 号：T7368产 地：中国大陆

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