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上海陶术生物科技有限公司 主营产品：生物试剂,实验服务等

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  • T73391BLM-IN-2；化合物 BLM-IN-2BLM-IN-2

    BLM-IN-2, a Bloom´s Syndrome Protein (BLM) inhibitor, exhibits an IC50 of 0.8 μM and shows efficacy in suppressing proliferation, invasion, cell cycle arrest, and apoptosis in colorectal cancer (CRC) cells, making it a potential candidate for CRC research.

    价 格：￥电议型 号：T73391产 地：中国大陆

  • T73335P2X7-IN-2；化合物 P2X7-IN-2P2X7-IN-2

    P2X7-IN-2, a P2X7 receptor inhibitor, effectively suppresses IL-Iβ release, demonstrating an inhibitory concentration (IC50) value of 0.01 nM. This compound is utilized in the study of autoimmunity, inflammation, and cardiovascular disease.

    价 格：￥电议型 号：T73335产 地：中国大陆

  • T73330JAK-IN-24；化合物 JAK-IN-24JAK-IN-24

    JAK-IN-24, a JAK inhibitor, exhibits IC50 values of 0.534 nM and 24 nM in the presence of 4 μM and 1 mM ATP, respectively. Additionally, it effectively inhibits STAT5 phosphorylation induced by PBMC IL-15 with an IC50 of 86.171 nM.

    价 格：￥电议型 号：T73330产 地：中国大陆

  • T73321CLK1-IN-2；化合物 CLK1-IN-2CLK1-IN-2

    CLK1-IN-2, a metabolically stable Clk1 inhibitor, exhibits selective activity for Clk1 with an IC50 value of 1.7 nM. It is applicable in researching tumor, Duchenne´s muscular dystrophy, and viral infections including HIV-1 and influenza.

    价 格：￥电议型 号：T73321产 地：中国大陆

  • T73309RET-IN-20；化合物 RET-IN-20RET-IN-20

    RET-IN-20, a potent RET inhibitor, demonstrates an IC50 value of 13.7 nM and effectively decreases the expression of p-Ret and p-Shc protein. Moreover, it induces apoptosis and exhibits antiproliferative and anti-tumor activity.

    价 格：￥电议型 号：T73309产 地：中国大陆

  • T73304ALR2-IN-2；化合物 ALR2-IN-2ALR2-IN-2

    ALR2-IN-2, a potent aldose reductase (ALR2) inhibitor, exhibits IC50 values of 27 nM for rat ALR2 and 228 nM for ALR1, respectively. This compound is utilized in the research of diabetic complications.

    价 格：￥电议型 号：T73304产 地：中国大陆

  • T73301ATR-IN-20；化合物 ATR-IN-20ATR-IN-20

    ATR-IN-20, a potent ATM/ATR inhibitor, showcases an IC50 value of 3 nM. It also exhibits inhibitory activity against mTOR with an IC50 of 18 nM, while maintaining selectivity over PI3Kα (100 nM), ATM (100 nM), and DNA-PK (662 nM). Additionally, ATR-IN-20 has an excellent pharmacokinetic profile with an oral bioavailability (F) of 30%, and demonstrates anticancer effects.

    价 格：￥电议型 号：T73301产 地：中国大陆

  • T73299APE1-IN-2；化合物 APE1-IN-2APE1-IN-2

    APE1-IN-2 (compound AP1), a Pt(IV) proagent, selectively targets the essential base excision repair protein apurinic/apyrimidinic endonuclease 1 (APE1). Exhibiting anticancer properties, APE1-IN-2 prompts the intracellular accumulation of platinum and initiates the activation of DNA damage response and apoptosis pathways [1].

    价 格：￥电议型 号：T73299产 地：中国大陆

  • T73280HBV-IN-29；化合物 HBV-IN-29HBV-IN-29

    HBV-IN-29 (ex8), a flavone derivative, functions as a potent inhibitor of covalently closed circular DNA (cccDNA), which is essential for viral RNA transcription and subsequent viral DNA replication. This compound shows promise in the study of HBV infection.

    价 格：￥电议型 号：T73280产 地：中国大陆

  • T73277FABP-IN-2；化合物 FABP-IN-2FABP-IN-2

    FABP-IN-2, a novel ligand for FABP3, demonstrates inhibition of both FABP3 and FABP4 with IC50 values of 1.16 μM and 4.27 μM, respectively.

    价 格：￥电议型 号：T73277产 地：中国大陆

  • T73276BTK-IN-23；化合物 BTK-IN-23BTK-IN-23

    BTK-IN-23 is a BTK inhibitor with an IC50 value of 12.8 nM, demonstrating kinase selectivity superior to Ibrutinib [1]. It also effectively inhibits BLX and BMX, with IC50 values of 35.6 nM and 5.7 nM, respectively.

    价 格：￥电议型 号：T73276产 地：中国大陆

  • T73275BTK-IN-22；化合物 BTK-IN-22BTK-IN-22

    BTK-IN-22, a BTK inhibitor (IC 50: 0.9 nM), also exhibits inhibition against BLX and BMX with IC 50 values of 1.4 and 1.2 nM, respectively. Demonstrating enhanced kinase selectivity, BTK-IN-22 outperforms Ibrutinib in this regard [1].

    价 格：￥电议型 号：T73275产 地：中国大陆

  • T73273SERT-IN-2；化合物 SERT-IN-2SERT-IN-2

    SERT-IN-2, a potent SERT inhibitor (IC 50 = 0.58 nM), exhibits promising efficacy as an anti-depressant. It demonstrates a favorable bioavailability of 83.28% in rats and has the ability to cross the blood-brain barrier.

    价 格：￥电议型 号：T73273产 地：中国大陆

  • T73270GSK3-IN-2；GSK3抑制剂2GSK3-IN-2

    GSK3-IN-2 is a potent GSK3 inhibitor [1] .

    价 格：￥电议型 号：T73270产 地：中国大陆

  • T73243NSD3-IN-2；化合物 NSD3-IN-2NSD3-IN-2

    NSD3-IN-2, a potent inhibitor of NSD3, exhibits an IC50 value of 17.97 μM. It effectively inhibits the growth and proliferation of non-small cell lung cancer (NSCLC) cell lines, including H460, H1299, and H1650, demonstrating significant anticancer activity.

    价 格：￥电议型 号：T73243产 地：中国大陆

  • T73235GPX4-IN-2；化合物 GPX4-IN-2GPX4-IN-2

    GPX4-IN-2 is a potent inhibitor of GPX4, exhibiting antiproliferative activity. It holds potential for cancer research applications.

    价 格：￥电议型 号：T73235产 地：中国大陆

  • T73191LONP1-IN-2；化合物 LONP1-IN-2LONP1-IN-2

    LONP1-IN-2 is a potent, selective inhibitor of LONP1, demonstrating an IC50 value of 0.187 μM for LONP1 and over 10 μM for the 20S proteasome. This specificity underlines its potential utility in cancer research.

    价 格：￥电议型 号：T73191产 地：中国大陆

  • T73183SMYD3-IN-2；化合物 SMYD3-IN-2SMYD3-IN-2

    SMYD3-IN-2, a potent inhibitor of SMYD3, demonstrates significant efficacy in combating gastric cancer by promoting lethal autophagy. It exhibits strong inhibitory activity against both SMYD3 and BGC823 cells, with IC 50 values of 0.81 μM and 0.75 μM, respectively. This compound holds potential for cancer research applications.

    价 格：￥电议型 号：T73183产 地：中国大陆

  • T73166FUBP1-IN-2；化合物 FUBP1-IN-2FUBP1-IN-2

    FUBP1-IN-2 is a potent inhibitor of far upstream binding protein 1 (FUBP1), effectively disrupting the FUBP1-FUSE interaction in the KH4 domain as demonstrated in a gel shift assay. This compound also exhibits binding affinity to FUBP1 in ChIP assays. Furthermore, FUBP1-IN-2 significantly downregulates c-Myc mRNA and protein levels, upregulates p21 mRNA and protein levels, and depletes intracellular polyamines.

    价 格：￥电议型 号：T73166产 地：中国大陆

  • T73163CDK7-IN-20；化合物 CDK7-IN-20CDK7-IN-20

    CDK7-IN-20 is a potent, selective, and irreversible inhibitor of Cyclin-Dependent Kinase 7 (CDK7) with an IC50 value of 4 nM, exhibiting over 206-fold selectivity against related kinases CDK1, CDK2, CDK3, CDK5, CDK6, CDK9, and CDK12. It holds potential for research into autosomal dominant polycystic kidney disease (ADPKD).

    价 格：￥电议型 号：T73163产 地：中国大陆

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