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  • T1470Fexofenadine hydrochloride；盐酸非索非那定Terfenidine carboxylate hydrochloride|||MDL-16455 hydrochloride|||

    Fexofenadine hydrochloride (Terfenidine carboxylate hydrochloride) is a second generation antihistamine that is used for the treatment of allergic rhinitis, angioedema and chronic urticaria.

    价 格：￥电议型 号：T1470产 地：中国大陆

  • T14687Deucravacitinib；化合物BMS-986165BMS-986165；BMS-986165

    Deucravacitinib (BMS-986165) inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases. Which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain.

    价 格：￥电议型 号：T14687产 地：中国大陆

  • T14686BMS-986163；化合物 T14686BMS-986163

    BMS-986163 is a negative allosteric modulator of GluN2B and the prodrug BMS-986163 rapidly converts to its active parent molecule BMS-986169 (Ki=4 nM, IC50=24 nM).

    价 格：￥电议型 号：T14686产 地：中国大陆

  • T14670BMS-1166 hydrochloride；化合物 T14670BMS-1166 hydrochloride

    Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM). BMS-1166 hydrochloride is an inhibitor of PD-1/PD-L1 interaction (IC50: 1.4 nM). BMS-1166 rivalries the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.

    价 格：￥电议型 号：T14670产 地：中国大陆

  • T14665LMotixafortide TFA(664334-36-5,Free)；化合物Motixafortide TFATF 14016 TFA|||BKT140 TFA|||BL-8040 TFA|||T1

    Motixafortide TFA(664334-36-5,Free) (BKT140 TFA) is an antagonist of CXCR4 with IC50 of ～1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.

    价 格：￥电议型 号：T14665L产 地：中国大陆

  • T14665Motixafortide化合物 T14665BL-8040|||BKT140 (4-fluorobenzoyl)|||TF14016

    Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).

    价 格：￥电议型 号：T14665产 地：中国大陆

  • T14616Biricodar；化合物 T14616VX-710；VX-710

    Biricodar is a P-glycoprotein and MRP-1 modulator.

    价 格：￥电议型 号：T14616产 地：中国大陆

  • T14556BI-167107；化合物 T14556BI-167107

    BI-167107 is a high affinity, full agonist that binds to the β2 adrenergic receptor (β2AR, Kd of 84 pM).

    价 格：￥电议型 号：T14556产 地：中国大陆

  • T14516BDP FL DBCO；化合物 T14516BDP FL DBCO

    BDP FL DBCO is a cleavable linker vital in ADC synthesis. BDP FL DBCO joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

    价 格：￥电议型 号：T14516产 地：中国大陆

  • T14500BAY-1316957；化合物 T14500BAY-1316957

    BAY-1316957 is a highly potent and selective EP4 receptor antagonist. With an IC50 of 15.3 nM. Good oral bioavailability[1].

    价 格：￥电议型 号：T14500产 地：中国大陆

  • T14493Balapiravir化合物 T14493R1626|||Ro 4588161

    Balapiravir (R1626, Ro 4588161) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479). IC50 Value: Target: HCV Balapiravir was discontinued for safety reasons in 28-36% of patients (most often for lymphopenia) and the percentage of patients with serious adverse events (especially hematological, infection, ocular events) was dose related. Balapiravir (R1626) is the tri-isobutyrate ester prodrug of R1479 under clinical develop

    价 格：￥电议型 号：T14493产 地：中国大陆

  • T14359AVX 13616；化合物 T14359AVX 13616

    AVX 13616, Avexa´s leading antibacterial candidate, demonstrates significant in vivo antibacterial efficacy, especially against drug-resistant Staphylococcus pathogens, with an IC50 value of 2-4 ?g/ml (MICs) and is targeted as an antibacterial agent. Comparable in activity to mupirocin within a nasal decolonization model, AVX13616 necessitated only a single application for effectiveness. This compound, alongside others, exhibited broad-spectrum antibacterial action, achieving MICs of 2-4 m

    价 格：￥电议型 号：T14359产 地：中国大陆

  • T14358Avoralstat；AVORALSTATBCX4161；BCX4161

    Avoralstat (BCX4161) is an oral plasma kallikrein (PKK) inhibitor. Which is used for the treatment of hereditary angioedema.

    价 格：￥电议型 号：T14358产 地：中国大陆

  • T14325Arterolane；青蒿氧烷OZ 277|||RBx 11160；OZ 277|||青蒿氧烷|||RBx 11160

    Arterolane is an antimalarial compound. For against P. falciparum Ro73 and W2, the IC50s are both 1.1 nM.

    价 格：￥电议型 号：T14325产 地：中国大陆

  • T14316AR-C155858；化合物AR-C155858AR-C155858

    AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3 nM and 10 nM).

    价 格：￥电议型 号：T14316产 地：中国大陆

  • T14306Apimostinel；化合物 T14306AGN-241660|||NRX-1074；AGN-241660|||NRX-1074

    Apimostinel (NRX-1074; AGN-241660) is a partial agonist of NMDA receptor.

    价 格：￥电议型 号：T14306产 地：中国大陆

  • T14216AMG 837；化合物 T14216AMG 837

    AMG 837 is a partial GPR40 agonist with an EC50 value of 13 nM, showcasing 85% of the maximal activity displayed by DHA in standard assay conditions, indicating its high potency and selectivity in vitro. This compound excels as a GPR40 agonist with a notable pharmacokinetic profile, effectively stimulating insulin secretion in a glucose-dependent manner in rodents and demonstrating potent insulin secretion stimulation in MIN6 cells, with efficacy comparable to that observed in aequorin Ca2+-flux

    价 格：￥电议型 号：T14216产 地：中国大陆

  • T14212AMG-1694；化合物AMG-1694AMG-1694

    AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models [1] and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates G

    价 格：￥电议型 号：T14212产 地：中国大陆

  • T14200AM-1638；化合物 T14200AM-1638

    AM-1638 is a full agonist of GPR40/FFA1 (EC50: 0.16 μM).

    价 格：￥电议型 号：T14200产 地：中国大陆

  • T14169Ald-Ph-PEG6-acid；化合物 T14169Ald-Ph-PEG6-acid

    Ald-Ph-PEG6-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

    价 格：￥电议型 号：T14169产 地：中国大陆

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