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T72868ADAMTS-5-IN-2;化合物 ADAMTS-5-IN-2ADAMTS-5-IN-2
ADAMTS-5-IN-2 is a potent inhibitor of ADAMTS-5, exhibiting an IC50 of 0.71 ?M, and holds potential for osteoarthritis research.
价 格:¥电议型 号:T72868产 地:中国大陆
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T72862PARP-2/1-IN-2化合物 PARP-2/1-IN-2ABT-888对映体
PARP-2/1-IN-2, an enantiomer of Veliparib, serves as a potent inhibitor of PARP, demonstrating inhibition constants (Kis) of 2 nM for PARP-2 and 5 nM for PARP-1. This compound exhibits a half-maximal effective concentration (EC50) of 3 nM in cell-based assays evaluating PARP activity [1].
价 格:¥电议型 号:T72862产 地:中国大陆
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T72828α-Amylase-IN-2;化合物 α-Amylase-IN-2α-Amylase-IN-2
α-Glucosidase-IN-3, an oxime ester derivative of oleanolic acid (OA), exhibits inhibitory activity against α-glucosidase (IC50 = 1.28 ?M) and α-amylase (IC50 = 3.8 ?M).
价 格:¥电议型 号:T72828产 地:中国大陆
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T72759c-Met/HDAC-IN-2;化合物 c-Met/HDAC-IN-2c-Met/HDAC-IN-2
c-Met/HDAC-IN-2 is a potent dual inhibitor of c-Met and HDAC, exhibiting IC50 values of 5.40 nM for c-Met and 18.49 nM for HDAC1, respectively. It demonstrates antiproliferative effects on various cancer cell lines, induces G2/M-phase arrest, and triggers apoptosis in HCT-116 cells, making it a promising candidate for anti-cancer resistance research.
价 格:¥电议型 号:T72759产 地:中国大陆
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T72746(R)-eIF4A3-IN-2;化合物 (R)-eIF4A3-IN-2(R)-eIF4A3-IN-2
(R)-eIF4A3-IN-2, a less active enantiomer of eIF4A3-IN-2, is a highly selective and noncompetitive inhibitor of the eukaryotic initiation factor 4A-3 (eIF4A3) with an IC50 of 110 nM.
价 格:¥电议型 号:T72746产 地:中国大陆
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T72721PD-1/PD-L1-IN-29;化合物 PD-1/PD-L1-IN-29PD-1/PD-L1-IN-29
PD-1/PD-L1-IN-29 (S4-1) is a potent inhibitor of the PD-1/PD-L1 interaction, with an IC50 value of 6.1 nM. It effectively binds to PD-L1, inhibiting the PD-1/PD-L1 interaction, promotes PD-L1 dimerization and its internalization, enhances localization to the endoplasmic reticulum, and facilitates PD-L1´s entry into the endoplasmic reticulum, demonstrating anticancer activity.
价 格:¥电议型 号:T72721产 地:中国大陆
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T72719Tubulin/MMP-IN-2;化合物 Tubulin/MMP-IN-2Tubulin/MMP-IN-2
Tubulin/MMP-IN-2, a dual inhibitor of tubulin and matrix metalloproteinases (MMPs), effectively inhibits tubulin polymerization and induces cell apoptosis. It demonstrates inhibitory activities against MMP-2, MMP-3, and MMP-9, with IC50 values of 24.95 μM, 31.60 μM, and 22.37 μM, respectively. This compound is utilized in cancer research.
价 格:¥电议型 号:T72719产 地:中国大陆
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T72700Cavα2δ1&NET-IN-2;化合物 Cavα2δ1&NET-IN-2Cavα2δ1&NET-IN-2
Cavα2δ1&NET-IN-2 . Cavα2δ1&NET-IN-2 inhibits Ca v α2δ-1 with a K i of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a K i of 59 nM and IC 50 of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain [1] .
价 格:¥电议型 号:T72700产 地:中国大陆
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T72691PD-1/PD-L1-IN-28;化合物 PD-1/PD-L1-IN-28PD-1/PD-L1-IN-28
PD-1/PD-L1-IN-28, an inhibitor of the PD-1/PD-L1 signaling pathway (IC 50 = 0.744 ?M), demonstrates promising research potential in tumor immunity. This immune checkpoint inhibitor effectively blocks the interaction within the pathway, offering insights into cancer treatment strategies.
价 格:¥电议型 号:T72691产 地:中国大陆
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T72680PD-1/PD-L1-IN-27;化合物 PD-1/PD-L1-IN-27PD-1/PD-L1-IN-27
PD-1/PD-L1-IN-27 is a potent inhibitor of PD-1/PD-L1, exhibiting an IC50 of 134 nM and demonstrating antitumor effects with minimal T cell cytotoxicity. It activates CD8+ T cells and mitigates T cell exhaustion [1].
价 格:¥电议型 号:T72680产 地:中国大陆
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T72675PD-1/PD-L1-IN-23;化合物 PD-1/PD-L1-IN-23PD-1/PD-L1-IN-23
PD-1/PD-L1-IN-23 is a potent, orally active ester prodrug of L7, a benzooxadiazole derivative, and functions as an inhibitor of PD-1/PD-L1. It has been biologically evaluated for its inhibitory effects on PD-L1, demonstrating significant antitumor effects in both syngeneic tumor models and PD-L1 humanized mice.
价 格:¥电议型 号:T72675产 地:中国大陆
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T72668PD-1/PD-L1-IN-26;化合物 PD-1/PD-L1-IN-26PD-1/PD-L1-IN-26
PD-1/PD-L1-IN-26 (Compound II-14) is a potent PD-1/PD-L1 inhibitor, demonstrating an IC50 of 0.0380 μM. It enhances the immune microenvironment by facilitating CD4+ T cell infiltration into tumor tissues, indicating potential use in cancer research [1].
价 格:¥电议型 号:T72668产 地:中国大陆
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T72662NMDAR/TRPM4-IN-2;化合物NMDAR/TRPM4-IN-2NMDAR/TRPM4-IN-2
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss in mice.NMDAR/TRPM4-IN-2 has neuroprotective activity against NMDA-induced hippocampal neuronal cell death and mitochondrial dysfunction. NMDAR/TRPM4-IN-2 showed neuroprotective activity against NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons with an IC50 value of 2.1 μM.
价 格:¥电议型 号:T72662产 地:中国大陆
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T7263SMS2-IN-2;化合物SMS2-IN-2SMS2 inhibitors;SMS2 inhibitors
SMS2-IN-2 (SMS2 inhibitors) is a potent, selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, (IC50s of 100 and 56 μM for SMS2 and SMS1, respectively). SMS2-IN-2 has anti-chronic inflammatory activity.
价 格:¥电议型 号:T7263产 地:中国大陆
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T72629PfGSK3/PfPK6-IN-2;化合物 PfGSK3/PfPK6-IN-2PfGSK3/PfPK6-IN-2
PfGSK3/PfPK6-IN-2, an effective dual inhibitor targeting Plasmodium falciparum GSK3/PK6 (PfGSK3/PfPK6), exhibits potent inhibitory activity with IC50 values of 172 nM for PfGSK3 and 11 nM for PfPK6, respectively. This compound is utilized in malaria research.
价 格:¥电议型 号:T72629产 地:中国大陆
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T72624Kallikrein 5-IN-2;化合物 Kallikrein 5-IN-2Kallikrein 5-IN-2
Kallikrein 5-IN-2 is a potent inhibitor of Kallikrein KLK5, exhibiting selectivity with a pIC50 value of 7.1. By inhibiting KLK5, it has the potential to normalize epidermal shedding, thereby reducing associated inflammation and itching.
价 格:¥电议型 号:T72624产 地:中国大陆
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T72608VEGFR-2/BRAF-IN-2;化合物 VEGFR-2/BRAF-IN-2VEGFR-2/BRAF-IN-2
VEGFR-2/BRAF-IN-2, as a dual VEGFR-2 and BRAF kinase inhibitor, exhibits potent IC50 values of 0.111 ?M, 0.089 ?M, and 0.071 ?M against VEGFR-2, BRAF V600E, and BRAF WT, respectively. This compound effectively induces apoptosis and predominantly arrests the cell cycle in the G1 phase.
价 格:¥电议型 号:T72608产 地:中国大陆
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T72581SARS-CoV MPro-IN-2;化合物 SARS-CoV MPro-IN-2SARS-CoV MPro-IN-2
SARS-CoV MPro-IN-2 effectively inhibits the SARS-CoV-2 main protease (M pro), crucial for the virus´s replication and transcription in host cells, with an IC50 value of 72.07 nM. Given its significant role in processing viral polyproteins, M pro is regarded as a key target in drug discovery efforts. Consequently, SARS-CoV MPro-IN-2 holds promise for COVID-19 research.
价 格:¥电议型 号:T72581产 地:中国大陆
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T72557Transketolase-IN-2;化合物 Transketolase-IN-2Transketolase-IN-2
Transketolase-IN-2 is a potent inhibitor of Transketolase, demonstrating significant inhibitory effects on Digitaria sanguinalis and Amaranthus retroflexus, with over 90% inhibition at 200 mg/L and approximately 80% at 100 mg/L. This compound is relevant for research in weed control.
价 格:¥电议型 号:T72557产 地:中国大陆
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T72554ARTD10/PARP10-IN-2;化合物 ARTD10/PARP10-IN-2ARTD10/PARP10-IN-2
ARTD10/PARP10-IN-2 is a potent, non-selective inhibitor of mono-ADP-ribosyltransferases ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 ARTD1/PARP1, exhibiting IC50 values of 2.0 μM and 9.7 μM, respectively.
价 格:¥电议型 号:T72554产 地:中国大陆