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  • T74691Aprinocarsen sodium；化合物 Aprinocarsen sodiumAprinocarsen sodium

    Aprinocarsen (ISIS 3521) sodium is a specific antisense oligonucleotide inhibitor targeting protein kinase C-alpha (PKC-α). It is a 20-mer oligonucleotide that modulates cell differentiation and proliferation. Demonstrating efficacy in inhibiting the growth of human tumor cell lines in nude mice, Aprinocarsen sodium presents significant chemotherapeutic potential against human cancers [1].

    价 格：￥电议型 号：T74691产 地：中国大陆

  • T74690Monarsen；化合物 MonarsenMonarsen

    Monarsen (EN101), a synthetic 20-base antisense oligodeoxynucleotide targeting the human AChE gene, is utilized in researching autoimmune myasthenia gravis (MG). This neuromuscular disorder is characterized by autoantibodies targeting the acetylcholine receptor (AChR).

    价 格：￥电议型 号：T74690产 地：中国大陆

  • T74689Zorevunersen；化合物 ZorevunersenZorevunersen

    Zorevunersen (STK-001), an antisense oligonucleotide, aims to elevate productive SCN1A mRNA levels, thereby enhancing Nav1.1 sodium channel protein expression. It is utilized in researching Dravet syndrome.

    价 格：￥电议型 号：T74689产 地：中国大陆

  • T74649Rugonersen；化合物 RugonersenRugonersen

    Rugonersen (RG6091; RO7248824), a locked-nucleic acid (LNA)-modified antisense oligonucleotide (ASO), reduces the silencing of ubiquitin-protein ligase E3A (UBE3A). This compound is significant in the research of Angelman syndrome (AS), a severe neurodevelopmental disorder resulting from the loss of neuronal E3 ligase UBE3A, demonstrating its utility in exploring treatments for AS [1] [2].

    价 格：￥电议型 号：T74649产 地：中国大陆

  • T74645Eplontersen；化合物 EplontersenEplontersen

    Eplontersen, a triantennary N-acetyl galactosamine (GalNAc3-7a)-conjugated antisense oligonucleotide, targets transthyretin (TTR) mRNA to suppress the synthesis of both variant and wild-type TTR proteins. The accumulation of misfolded TTR proteins contributes to the formation of amyloid fibrils in the heart and peripheral nerves, resulting in amyloid TTR (ATTR) amyloidosis [1] [2] [3].

    价 格：￥电议型 号：T74645产 地：中国大陆

  • T74643RSS0680；化合物 RSS0680RSS0680

    RSS0680 is a protein kinase degrader that degrades a variety of kinases and can be used to study diseases caused by kinase abnormalities.

    价 格：￥电议型 号：T74643产 地：中国大陆

  • T74594Tonlamarsen；化合物 TonlamarsenTonlamarsen

    Tonlamarsen is a angiotensinogen synthesis reducer, with antihypertensive activity [1] .

    价 格：￥电议型 号：T74594产 地：中国大陆

  • T74573Bezeparsen；化合物 BezeparsenBezeparsen

    Bezeparsen is a PCSK9 synthesis inhibitor [1] .

    价 格：￥电议型 号：T74573产 地：中国大陆

  • T74569Bepirovirsen；化合物 BepirovirsenBepirovirsen

    Bepirovirsen, an antisense oligonucleotide, targets all HBV messenger RNAs, resulting in decreased levels of HBV-derived RNAs, HBV DNA, and viral proteins. It is utilized in researching chronic HBV infection. The binding site sequence of Bepirovirsen is (GCACTTCGCTTCACCTCTGC) [1].

    价 格：￥电议型 号：T74569产 地：中国大陆

  • T74527Anti-MRSA agent 4；化合物 Anti-MRSA agent 4Anti-MRSA agent 4

    Anti-MRSA agent 4 (compound 7a), a selective and potent inhibitor of Gram-positive Methicillin-resistant Staphylococcus aureus (MRSA) growth, demonstrates a minimum inhibitory concentration (MIC) of ≤ 0.26 ?M. It exhibits neither cytotoxic nor hemolytic activity in HEK293 cells [1].

    价 格：￥电议型 号：T74527产 地：中国大陆

  • T74436Danvatirsen；化合物 DanvatirsenDanvatirsen

    Danvatirsen, an antisense oligonucleotide targeting STAT3, demonstrates potential antitumor activity by binding to STAT3 mRNA. This interaction inhibits the translation of the transcript, resulting in the suppression of STAT3 expression, which in turn induces tumor cell apoptosis and reduces tumor cell growth.

    价 格：￥电议型 号：T74436产 地：中国大陆

  • T74435Alicaforsen sodium；化合物 Alicaforsen sodiumAlicaforsen sodium

    Alicaforsen sodium is a 20-base antisense oligonucleotide that targets and inhibits the production of ICAM-1, a critical adhesion molecule responsible for mediating leukocyte migration and trafficking toward inflammation sites.

    价 格：￥电议型 号：T74435产 地：中国大陆

  • T74434Apatorsen；化合物 ApatorsenApatorsen

    Apatorsen, an antisense oligonucleotide, targets Hsp27 mRNA to inhibit Hsp27 protein production by binding to it.

    价 格：￥电议型 号：T74434产 地：中国大陆

  • T74433Apatorsen sodium；化合物 Apatorsen sodiumApatorsen sodium

    Apatorsen (sodium) is an antisense oligonucleotide that targets Hsp27 mRNA, effectively inhibiting the production of Hsp27 protein.

    价 格：￥电议型 号：T74433产 地：中国大陆

  • T74432Mongersen；化合物 MongersenMongersen

    Mongersen (GED-0301), a specific and orally active SMAD7 antisense oligonucleotide, enhances TGF-β1 activity, reducing inflammatory signals. It has been shown to alleviate experimental colitis resembling Crohn´s disease in mice [1] [2].

    价 格：￥电议型 号：T74432产 地：中国大陆

  • T74420Obeversen；化合物 ObeversenObeversen

    Obeversen is a DGAT-2 synthesis reducer [1] .

    价 格：￥电议型 号：T74420产 地：中国大陆

  • T74419Mulnitorsen；化合物 MulnitorsenMulnitorsen

    Mulnitorsen acts as an inhibitor of antisense non-coding mitochondrial RNA (ASncmtRNA) synthesis and serves as an antitumor agent [1].

    价 格：￥电议型 号：T74419产 地：中国大陆

  • T74250Custirsen；化合物 CustirsenCustirsen

    Custirsen, a highly specific antisense oligonucleotide, inhibits the production of clusterin—an antiapoptotic protein upregulated in response to chemotherapy, thereby conferring treatment resistance.

    价 格：￥电议型 号：T74250产 地：中国大陆

  • T74225ROS-ERS inducer 1；化合物 ROS-ERS inducer 1ROS-ERS inducer 1

    ROS-ERS inducer 1, a type II immunogenic cell death (ICD) inducer, is a Pt(II)-N-heterocyclic carbene (Pt(II)-NHC) complex derived from 4,5-diarylimidazole. It induces endoplasmic reticulum stress (ERS) along with reactive oxygen species (ROS) generation, leading to the release of damage-associated molecular patterns (DAMPs) in HCC cells, showcasing significantly higher anticancer activities than Cisplatin [1].

    价 格：￥电议型 号：T74225产 地：中国大陆

  • T74204Trabedersen；化合物 TrabedersenTrabedersen

    Trabedersen (AP 12009), an antisense oligodeoxynucleotide, specifically targets and inhibits TGF-β2 (TGF-beta/Smad), making it useful for researching malignant brain tumors and other solid tumors with high TGF-β2 expression, including those in the skin, pancreas, and colon [1] [2].

    价 格：￥电议型 号：T74204产 地：中国大陆

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