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T83818Isoguanosine-5’-O-triphosphate sodium；化合物 Isoguanosine-5’-O-triphosphate sodium2-Hydroxyadenosine 5’
Isoguanosine-5´-O-triphosphate, an isomer of guanosine 5´-triphosphate (GTP) and a phosphorylated derivative of crotonoside, does not promote microtubule assembly like GTP. At a concentration of 2 mM, it hampers transcription and triggers T to C mutations in reverse transcriptase assays. This compound aids in assessing the substrate specificity of both phosphofructokinase and mutT homolog 1 (MTH1).
价 格：￥电议型 号：T83818产 地：中国大陆
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T83817Isoguanosine-5’-O-diphosphate sodium；化合物 Isoguanosine-5’-O-diphosphate sodiumisoGDP；isoGDP
Isoguanosine-5´-O-diphosphate (isoGDP), an isomer of GDP and a phosphorylated variant of crotonoside, acts as a mitochondrial ATPase inhibitor, demonstrating effectiveness at a concentration of 3 ?M (IC50 = 3 ?M).
价 格：￥电议型 号：T83817产 地：中国大陆
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T83816Cytidine-5’-O-(2-thiodiphosphate) sodium；化合物 Cytidine-5’-O-(2-thiodiphosphate) sodiumCDP-β-S；CDP-β-S
Cytidine-5’-O-(2-thiodiphosphate) (CDP-β-S), a non-hydrolyzable derivative of CDP exhibiting antioxidant activity, effectively scavenges free radicals as evidenced by its performance in the Trolox equivalent absorbance capacity (TEAC) assay at concentrations between 5 and 20 ?M.
价 格：￥电议型 号：T83816产 地：中国大陆
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T838156-Chloropurine riboside-5’-triphosphate sodium；化合物 6-Chloropurine riboside-5’-triphosphate sodium6-c
6-Chloropurine riboside-5´-triphosphate serves as both an inhibitor and an activator in biochemical processes. It inhibits the RNA triphosphatase mRNA-capping enzyme subunit β (Cet1; IC50 = 2 ?M for the GTPase activity of the S. cerevisiae enzyme), proving its efficacy against the enzyme responsible for the capping of mRNA molecules. Additionally, it acts as a phosphorylated derivative of 6-chloropurine riboside. This compound also activates the E. coli enzyme aspartate carbamoyltransferas
价 格：￥电议型 号：T83815产 地：中国大陆
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T838148-Bromoguanosine-5’-O-triphosphate sodium；化合物 8-Bromoguanosine-5’-O-triphosphate sodium8-bromo GTP；8
8-Bromoguanosine-5´-O-triphosphate, a derivative of guanosine 5´-triphosphate (GTP) - the energy substrate for protein synthesis and gluconeogenesis, acts as an inhibitor of the E. coli GTPase FtsZ with an inhibition constant (Ki) of 31.8 ?M. Furthermore, at a concentration of 500 ?M, it facilitates the assembly of porcine brain microtubules in a cell-free assay.
价 格：￥电议型 号：T83814产 地：中国大陆
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T83808Sp-Adenosine-5’-O-(1-thiotriphosphate) sodium；化合物 Sp-Adenosine-5’-O-(1-thiotriphosphate) sodiumSp-AT
Sp-Adenosine-5´-O-(1-thiotriphosphate) (Sp-ATP-α-S), an isomer of the ATP-α-S sulfur-containing nucleotide derivative and a purinergic P2Y1 receptor agonist, effectively increases calcium mobilization in HEK293 cells harboring the P2Y1 receptor with an EC50 of 9.4 nM for the human receptor. It also inhibits ADP-induced human isolated platelet aggregation with a Ki value of 4 μM and prompts relaxation in carbamoylcholine-tightened guinea pig taenia coli, achieving an EC50 of 426 nM.
价 格：￥电议型 号：T83808产 地：中国大陆
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T83807Rp-Adenosine-5’-O-(1-thiotriphosphate) sodium；化合物 Rp-Adenosine-5’-O-(1-thiotriphosphate) sodiumRp-AT
Rp-Adenosine-5´-O-(1-thiotriphosphate) (Rp-ATP-α-S), a sulfur-containing nucleotide derivative isomer and a purinergic P2Y1 receptor agonist, promotes calcium mobilization in HEK293 cells expressing the human P2Y1 receptor (EC50 = 75 nM). This compound exhibits binding affinity to washed isolated human platelets (Ki = 156 nM) and attenuates ADP-induced aggregation in human platelet-rich plasma (PRP; pA2 = 4.74), as well as inhibits cAMP production triggered by prostaglandin E1 (PGE1) in hu
价 格：￥电议型 号：T83807产 地：中国大陆
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T83806Sp-Adenosine-5’-O-(1-thiodiphosphate) sodium；化合物 Sp-Adenosine-5’-O-(1-thiodiphosphate) sodiumSp-ADP-
Sp-Adenosine-5’-O-(1-thiodiphosphate) (Sp-ADP-α-S), an isomer of the sulfur-containing nucleotide derivative ADP-α-S, functions as an inhibitor of phosphorylase kinase with an inhibition constant (Ki) of 0.53 ?M. This compound also promotes aggregation of isolated human platelets with an effective concentration (EC50) of 20 ?M and induces relaxation in carbamoylcholine-precontracted guinea pig taenia coli with an EC50 of 58.9 ?M.
价 格：￥电议型 号：T83806产 地：中国大陆
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T83805Rp-Adenosine-5’-O-(1-thiodiphosphate) sodium；化合物 Rp-Adenosine-5’-O-(1-thiodiphosphate) sodiumRp-ADP-
Rp-Adenosine-5´-O-(1-thiodiphosphate) (Rp-ADP-α-S), a sulfur-containing isomer of the nucleotide derivative ADP-α-S, acts as an inhibitor of phosphorylase kinase with an inhibition constant (Ki) of 0.53 ?M. This compound also induces aggregation in isolated human platelets with an effective concentration (EC50) of 20 ?M and promotes relaxation in guinea pig taenia coli that has been precontracted with carbamoylcholine, with an EC50 of 58.9 ?M.
价 格：￥电议型 号：T83805产 地：中国大陆
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T83802TNP-ATP sodium；化合物 TNP-ATP sodiumTNP-ATP sodium
TNP-ATP, a derivative of ATP, acts as an antagonist to the purinergic P2Y1, P2X3, and P2X2/3 receptors, demonstrating selectivity by showing lower inhibitory concentrations (IC50 = 6, 0.9, 7 nM, respectively) compared to the P2X2, P2X4, and P2X7 receptors (IC50 = 2, 15.2, >30 ?M, respectively) in HEK293 cells expressing these human receptors. It effectively diminishes acetic acid-induced calcium influx in 1321N1 cells targeting P2X3 and P2X2/3 receptors (IC50 = 100 and 62 nM, respectively) and a
价 格：￥电议型 号：T83802产 地：中国大陆
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T83801ε-NAADP+ sodium；化合物 ε-NAADP+ sodiumEtheno-NAADP|||β-Nicotinic Acid-1|||N6-Ethenoadenine dinucleotide
ε-NAADP+ is a fluorescent derivative of NAADP, known for inducing calcium mobilization. It effectively induces calcium release in sea urchin egg homogenates with an EC50 of 5 ?M. The compound exhibits excitation and emission maxima at 275 nm and 410 nm, respectively. Notably, its emission intensity increases three-fold when dissolved in DMSO.
价 格：￥电议型 号：T83801产 地：中国大陆
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T838006-Biotin-17-NAD+ sodium；化合物 6-Biotin-17-NAD+ sodium6-Biotin-17-Nicotinamide adenine dinucleotide|||β
6-Biotin-17-NAD+, a biotinylated derivative of the signaling molecule and enzyme cofactor NAD+, is utilized in high-throughput screening (HTS) assays to measure the activity of mitochondrial complex I, also referred to as NADH dehydrogenase.
价 格：￥电议型 号：T83800产 地：中国大陆
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T837996-alkyne NAD+ sodium；化合物 6-alkyne NAD+ sodiumβ-Nicotinamide-N6-propargyladenine dinucleotide|||6-Par
6-alkyne NAD+, a clickable variant of the signaling molecule and enzyme cofactor NAD+, facilitates the fluorescent tagging for the detection of poly(ADP-ribose) polymerase (PARP) protein substrates.
价 格：￥电议型 号：T83799产 地：中国大陆
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T837988-bromo NAD+ sodium；化合物 8-bromo NAD+ sodium8-bromo Nicotinamide adenine dinucleotide|||N(8-bromo-A)D
8-Bromo NAD+ serves as a prodrug for the cyclic ADP-ribose (cADPR) inhibitor, 8-bromo cADPR, undergoing conversion to its active form by the enzyme CD38. At a concentration of 1 mM, it effectively inhibits the rise in intracellular calcium levels and chemotaxis triggered by N-formyl-Met-Leu-Phe (fMLP) in mouse bone marrow-derived neutrophils. Furthermore, when applied at 100 ?M, this compound reduces LPS-induced nitrite production and decreases the secretion of TNF-α and IL-2 in mouse primary mi
价 格：￥电议型 号：T83798产 地：中国大陆
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T837897-Deazaadenosine-5’-O-diphosphate sodium；化合物 7-Deazaadenosine-5’-O-diphosphate sodium7-CH-ADP|||Tube
7-Deazaadenosine-5´-O-diphosphate, a modified nucleotide and metabolite of tubercidin, is generated through phosphorylation of tubercidin and further undergoes phosphorylation to become the active metabolite 7-deazaadenosine-5´-O-triphosphate.
价 格：￥电议型 号：T83789产 地：中国大陆
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T837868-Chloroadenosine-5’-triphosphate sodium；化合物 8-Chloroadenosine-5’-triphosphate sodium8-chloro ATP；8-
8-Chloroadenosine-5’-triphosphate (8-chloro ATP), a potent metabolite of the anticancer agent 8-chloro cyclic AMP (cAMP) and a nucleotide derivative, is produced through the biotransformation of 8-chloro cAMP into 8-chloroadenosine, followed by mono- and diphosphate intermediates. Accumulating for up to 12 hours after the administration of 8-chloro cAMP or 8-chloroadenosine, 8-chloro ATP inhibits cell growth, diminishes endogenous ATP levels, and reduces RNA synthesis without affecting DNA synth
价 格：￥电议型 号：T83786产 地：中国大陆
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T837852-Chloroadenosine-5’-O-diphosphate sodium；化合物 2-Chloroadenosine-5’-O-diphosphate sodium2-chloro ADP；
2-Chloroadenosine-5´-O-diphosphate, a purine nucleotide adenosine 5´diphosphate (ADP) derivative, demonstrates multiple biological activities. It promotes aggregation and inhibits cyclic AMP (cAMP) production, triggered by prostaglandin E2 (PGE2), in a concentration-dependent manner within isolated human platelet-rich plasma. Additionally, this compound facilitates the relaxation of precontracted isolated guinea pig taenia coli strips (pD2 = 6.74) and reduces arterial blood pressure
价 格：￥电议型 号：T83785产 地：中国大陆
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T837785-(3-Aminoallyl)uridine-5’-O-triphosphate sodium；化合物 5-(3-Aminoallyl)uridine-5’-O-triphosphate sodiu
Aminoallyl-UTP (5-(3-Aminoallyl)uridine-5´-O-triphosphate) is an amine-modified nucleotide utilized in affinity-tagged UTP synthesis. Its incorporation into complementary RNA (cRNA) and bacterial transfer-messenger RNA (tmRNA) enables the creation of fluorescently labeled probes for microarrays.
价 格：￥电议型 号：T83778产 地：中国大陆
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T837721-Linoleoyl Lysophosphatidic Acid sodium；化合物 1-Linoleoyl Lysophosphatidic Acid sodium1-Linoleoyl-2-h
1-Linoleoyl lysophosphatidic acid (1-linoleoyl LPA), a glycerophospholipid with linoleic acid at its sn-1 position, acts as an LPA2 receptor agonist and is the predominant LPA form in both mouse and human plasma. This compound preferentially boosts intracellular calcium in Sf9 cells expressing the LPA2 receptor (EC50 = ~10 nM), compared to those with LPA1 and LPA3 receptors (EC50s = ~200 and ~80 nM, respectively). Notably, 1-linoleoyl LPA serum concentrations are elevated in mice with NCTC clone
价 格：￥电议型 号：T83772产 地：中国大陆
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T83676Tianeptine Metabolite MC5 sodium；化合物 Tianeptine Metabolite MC5 sodiumTianeptine Metabolite MC5 sodiu
Tianeptine metabolite MC5, an active derivative of the atypical antidepressant tianeptine produced through β-oxidation, exhibits selective G protein activation in bioluminescence resonance energy transfer (BRET) assays. Utilizing HEK293T cells expressing the human μ-opioid receptor (MOR) over the human δ-opioid receptor (DOR; EC50s = 0.454 and >100 ?M, respectively), it demonstrates specificity. Moreover, this metabolite reduces immobility in wild-type mice during the forced swim test at a dose
价 格：￥电议型 号：T83676产 地：中国大陆
