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T81296RET-IN-26;化合物 RET-IN-26RET-IN-26
RET-IN-26 (compound D5) is a kinase inhibitor that selectively targets the RET protein with an IC50 value of 0.33 μM [1].
价 格:¥电议型 号:T81296产 地:中国大陆
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T81269RIPK1-IN-16;化合物 RIPK1-IN-16RIPK1-IN-16
RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo. It shields mice from TNF-induced systemic inflammatory response syndrome and sepsis [1].
价 格:¥电议型 号:T81269产 地:中国大陆
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T81241RXFP1 receptor agonist-6;化合物 RXFP1 receptor agonist-6RXFP1 receptor agonist-6
RXFP1 receptor agonist-6 (Example 7) serves as an agonist for the RXFP1 receptor and effectively suppresses cAMP production in HEK293 cells that stably express the human RXFP1, exhibiting an EC50 of 12 nM [1].
价 格:¥电议型 号:T81241产 地:中国大陆
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T79832ROCK2-IN-6;化合物 ROCK2-IN-6ROCK2-IN-6
ROCK2-IN-6 (Comp A) is a selective inhibitor of ROCK2, applicable in the study and treatment of ROCK-mediated, autoimmune, and inflammatory diseases [1].
价 格:¥电议型 号:T79832产 地:中国大陆
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T796845-HT6R antagonist 1;化合物 5-HT6R antagonist 15-HT6R antagonist 1
Compound 8 (5-HT6R antagonist 1), a 5-HT6R antagonist (K i : 5 nM), not only demonstrates inhibition of platelet aggregation and excellent metabolic stability but also reverses MK-801-induced memory impairments in rats, suggesting its utility in Alzheimer´s disease (AD) research [1].
价 格:¥电议型 号:T79684产 地:中国大陆
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T79233RdRP-IN-6;化合物 RdRP-IN-6RdRP-IN-6
RdRP-IN-6 (compound 27) is an inhibitor of RNA-dependent RNA polymerase (RdRp), exhibiting an IC90 value of 14.1 μM. It has potential applications in antiviral and anticancer research [1].
价 格:¥电议型 号:T79233产 地:中国大陆
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T79077ROCK-IN-6;化合物 ROCK-IN-6ROCK-IN-6
ROCK-IN-6, a selective ROCK2 inhibitor, exhibits potent inhibition with an IC50 of 2.19 nM and holds promise for research into glaucoma and retinal diseases [1].
价 格:¥电议型 号:T79077产 地:中国大陆
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T79043RIP1 kinase inhibitor 6;化合物 RIP1 kinase inhibitor 6RIP1 kinase inhibitor 6
RIP1 Kinase Inhibitor 6 is a potent and selective inhibitor of RIP1 kinase, demonstrating inhibitory activity with an IC50 of less than 100 nM in a human R1P1 kinase assay[1].
价 格:¥电议型 号:T79043产 地:中国大陆
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T77670(1R,5S,6r)-N-(2-methyl-1-((3-methylpyridin-2-yl)oxy)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxa
(1R,5S,6r)-N-(2-methyl-1-((3-methylpyridin-2-yl)oxy)propan-2-yl)-3-azabicyclo[3.1.0]hexane-6-carboxamide L(+)-Tartaric acid is a potential SSTR4 agonist.
价 格:¥电议型 号:T77670产 地:中国大陆
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T74698RMC-6236;化合物 RMC-6236RMC6236;RMC6236
RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer.
价 格:¥电议型 号:T74698产 地:中国大陆
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T73256RET-IN-16;化合物 RET-IN-16RET-IN-16
RET-IN-16 is a potent, selective inhibitor of RET, exhibiting IC50 values of 3.98 nM for RET(WT), 8.42 nM for RET(M918T), 15.05 nM for RET(V804L), 7.86 nM for RET(V804M), 5.43 nM for RET-CCDC6, and 8.86 nM for RET-KIF5B, indicating its high efficacy across different RET mutations. It possesses anticancer properties.
价 格:¥电议型 号:T73256产 地:中国大陆
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T72861(6R)-ML753286;化合物 (6R)-ML753286(6R)-ML753286
´(6R)-ML753286, an isomer of ML753286, is an orally active, selective Breast Cancer Resistance Protein (BCRP) inhibitor, demonstrating an IC50 of 0.6 μM. It exhibits high permeability and low to medium clearance in rodent and human liver S9 fractions, with cross-species plasma stability [1].´
价 格:¥电议型 号:T72861产 地:中国大陆
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T72254RORγt inverse agonist 26;化合物 RORγt inverse agonist 26RORγt inverse agonist 26
RORγt inverse agonist 26, a potent reverse agonist of RORγt, effectively modulates Th17 cell differentiation and suppresses IL-17 production. This compound shows promising potential for researching inflammation and autoimmune diseases.
价 格:¥电议型 号:T72254产 地:中国大陆
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T71398RO5126946;化合物 RO5126946RO5126946
RO5126946 is a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator. RO5126946 allosterically modulates α7nAChR activity. RO5126946 increased acetylcholine-evoked peak current and delayed current decay but did not affect the recovery of α7nAChRs from desensitization. In addition, RO5126946´s effects were absent when nicotine-evoked currents were completely blocked by coapplication of the α7nAChR-selective antagonist methyl-lycaconitine.
价 格:¥电议型 号:T71398产 地:中国大陆
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T7117Sapropterin dihydrochloride;盐酸沙丙蝶呤Sapropterin Hydrochloride|||6R-Tetrahydro-L-biopterin dihydrochlor
Sapropterin dihydrochloride (6R-BH4 dihydrochloride) is phenylalanine hydroxylase agonist that is approved for the treatment of BH4 responsive PKU.
价 格:¥电议型 号:T7117产 地:中国大陆
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T67310(6R,7R)-7-Amino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;化合物 (6R,7R)-7-Am
(6R,7R)-7-Amino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T67310 and the CAS number is 79349-82-9.
价 格:¥电议型 号:T67310产 地:中国大陆
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T67293(2R,3R,4S,5R,6R)-2-Bromo-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpro
(2R,3R,4S,5R,6R)-2-Bromo-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate) is a useful organic compound for research related to life sciences. The catalog number is T67293 and the CAS number is 81058-27-7.
价 格:¥电议型 号:T67293产 地:中国大陆
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T67292(2S,3R,4S,5R,6R)-3,4,5-Tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol;化合物 (2S,3R,4S,5
(2S,3R,4S,5R,6R)-3,4,5-Tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol is a useful organic compound for research related to life sciences. The catalog number is T67292 and the CAS number is 6564-72-3.
价 格:¥电议型 号:T67292产 地:中国大陆
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T67174(2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-
(2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol is a useful organic compound for research related to life sciences and the catalog number is T67174.
价 格:¥电议型 号:T67174产 地:中国大陆