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  • T75149PROTAC BRD4 Degrader-19；化合物 PROTAC BRD4 Degrader-19PROTAC BRD4 Degrader-19

    PROTAC BRD4 Degrader-19 (compound 176) is a proteolysis-targeting chimera (PROTAC) designed to specifically degrade the BRD4 protein, offering potential utility in cancer research [1].

    价 格：￥电议型 号：T75149产 地：中国大陆

  • T74270PROTAC BRD4 Degrader-17；化合物 PROTAC BRD4 Degrader-17PROTAC BRD4 Degrader-17

    PROTAC BRD4 Degrader-17 (compound 13i), a potent inhibitor, exhibits IC50 values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)), effectively reducing Cyclin B1 expression linked with G2/M phase progression and significantly inducing apoptosis in MV-4-11 cells [1].

    价 格：￥电议型 号：T74270产 地：中国大陆

  • T74126PROTAC BRD4 Degrader-14；化合物 PROTAC BRD4 Degrader-14PROTAC BRD4 Degrader-14

    PROTAC BRD4 Degrader-14, a PROTAC (Proteolysis Targeting Chimera) linked by ligands to von Hippel-Lindau and BRD4, exhibits IC50 values of 1.8 nM and 1.7 nM for BRD4 BD1 and BD2, respectively. This compound effectively degrades the BRD4 protein in PC3 prostate cancer cells [1].

    价 格：￥电议型 号：T74126产 地：中国大陆

  • T74125PROTAC BRD4 Degrader-12；化合物 PROTAC BRD4 Degrader-12PROTAC BRD4 Degrader-12

    PROTAC BRD4 Degrader-12 (compound 9c) is a PROTAC that links von Hippel-Lindau and BRD4 ligands. When conjugated with STEAP1 and CLL1 antibodies, this compound effectively degrades BRD4 protein in PC3 prostate cancer cells, demonstrating potent activity with DC50 values of 0.39 nM and 0.24 nM, respectively [1].

    价 格：￥电议型 号：T74125产 地：中国大陆

  • T74124PROTAC BRD4 Degrader-11；化合物 PROTAC BRD4 Degrader-11PROTAC BRD4 Degrader-11

    PROTAC BRD4 Degrader-11 (compound 9a), a PROTAC linked through ligands to von Hippel-Lindau and BRD4, effectively targets and degrades the BRD4 protein in PC3 prostate cancer cells when conjugated with STEAP1 and CLL1 antibodies. This compound exhibits potent activity, with degradation concentration half-maximal (DC50) values of 0.23 nM and 0.38 nM for the respective conjugations [1].

    价 格：￥电议型 号：T74124产 地：中国大陆

  • T74090PROTAC BRD4 Degrader-7；化合物 PROTAC BRD4 Degrader-7PROTAC BRD4 Degrader-7

    PROTAC BRD4 Degrader-7, a potent bromodomain BRD4 inhibitor exemplified by compound 1a, demonstrates half-maximal inhibitory concentrations (IC50s) of 15.5 nM and 12.3 nM for BRD4-BD1 and BRD4-BD2, respectively [1].

    价 格：￥电议型 号：T74090产 地：中国大陆

  • T73958PROTAC BRD4 Degrader-6；化合物 PROTAC BRD4 Degrader-6PROTAC BRD4 Degrader-6

    PROTAC BRD4 Degrader-6 (compound 32a), a potent small-molecule degrader of BRD4, exhibits an IC50 of 2.7 nM for BRD4 BD1. It effectively degrades BRD4 protein, suppresses c-Myc expression, and inhibits the proliferation of the pancreatic cancer cell line BxPC3 by inducing apoptosis. This compound is applicable in research on human pancreatic cancer [1].

    价 格：￥电议型 号：T73958产 地：中国大陆

  • T73830BRD4 Inhibitor-16；化合物 BRD4 Inhibitor-16BRD4 Inhibitor-16

    BRD4 Inhibitor-16 (Compound 4) is a potent inhibitor of bromodomain 4 (BRD4), whose overexpression is closely correlated with various human cancers through the regulation of histone post-translational modifications. It serves as a valuable tool for explorative studies focused on BRD4 inhibition, facilitating an enhanced comprehension of BRD4 inhibitor release-related information [1].

    价 格：￥电议型 号：T73830产 地：中国大陆

  • T73296iBRD4-BD1；化合物 iBRD4-BD1iBRD4-BD1

    iBRD4-BD1 is a selective inhibitor of the BRD4 bromodomain, exhibiting inhibition activity with an IC50 value of 12 nM. It is utilized in the research of inflammation and oncology.

    价 格：￥电议型 号：T73296产 地：中国大陆

  • T72636BRD4 Inhibitor-26；化合物 BRD4 Inhibitor-26BRD4 Inhibitor-26

    BRD4 Inhibitor-26, a bromodomain protein 4 (BRD4) inhibitor/nitric oxide-donator, exhibits inhibitory activity against BRD4 (BD1) and BRD4 (BD2) with IC50 values of 0.82 μM and 1.94 μM, respectively. It is utilized in ovarian cancer research.

    价 格：￥电议型 号：T72636产 地：中国大陆

  • T72630BRD4 Inhibitor-25；化合物 BRD4 Inhibitor-25BRD4 Inhibitor-25

    BRD4 Inhibitor-25, a chemical compound targeting the BD1 and BD2 domains of BRD4 with half-maximal inhibitory concentrations (IC50s) of 0.82 μM and 1.94 μM respectively, demonstrates efficacy in inducing apoptotic and autophagic cell death in ovarian cancer cells. This compound is utilized in researching cancers, cardiovascular, neuromuscular, and inflammatory disorders.

    价 格：￥电议型 号：T72630产 地：中国大陆

  • T69506dBRD4-BD1；化合物 dBRD4-BD1dBRD4-BD1

    dBRD4-BD1 is a selective BRD4 bromodomain inhibitor. dBRD4-BD1 can selectively degrade BRD4 (DC50 = 280 nM). Notably, dBRD4-BD1 upregulates BRD2/3, a result not observed with degraders using pan-BET ligands. Designing BRD4 selectivity up front enables analysis of BRD4 biology without wider BET-inhibition and simplifies designing BRD4-selective heterobifunctional molecules, such as degraders with new E3 recruiting ligands or for additional probes beyond degraders.

    价 格：￥电议型 号：T69506产 地：中国大陆

  • T64192BRD4 D1-IN-2；化合物 BRD4 D1-IN-2BRD4 D1-IN-2

    BRD4 D1-IN-2 (compound 26) is a selective and potent inhibitor of BRD4 D1 with an IC50 value of less than 0.092 μM. BRD4 D1-IN-2 has a 15 nM affinity for BRD4 D1 and is more than 500-fold selective for BRD2 D1 and BRD4 D2.

    价 格：￥电议型 号：T64192产 地：中国大陆

  • T64117BRD4-BD1-IN-2；BRD4-BD1抑制剂2BRD4-BD1-IN-2

    BRD4-BD1-IN-2 is a selective and potent BRD4-BD1 inhibitor with an IC50 value of 2.51 ?M, which is 20-fold greater than the inhibitory activity against BRD4-BD2.BRD4-BD1-IN-2 can be used in the study of cardiovascular and cancer-related diseases.

    价 格：￥电议型 号：T64117产 地：中国大陆

  • T64089BRD4 D1-IN-1；化合物 BRD4 D1-IN-1BRD4 D1-IN-1

    BRD4 D1-IN-1 is a selective inhibitor of BRD4 D1 with an IC50 <0.092 μM. BRD4 D1-IN-1 has an affinity of 18 nM and over 500-fold selectivity for BRD4 D1 and BRD4 D2.

    价 格：￥电议型 号：T64089产 地：中国大陆

  • T64058PLK1/BRD4-IN-1；化合物 PLK1/BRD4-IN-1PLK1/BRD4-IN-1

    PLK1/BRD4-IN-1 (9b) is an orally active dual inhibitor of PLK1 (IC50: 22 nM) and BRD4 (IC50: 109 nM). It has been shown to have good anti-tumour effects in vivo.

    价 格：￥电议型 号：T64058产 地：中国大陆

  • T63991BRD4/CK2-IN-1；化合物 BRD4/CK2-IN-1BRD4/CK2-IN-1

    BRD4/CK2-IN-1 is the first potent, orally active dual-target inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2), acting on both BRD4 (IC50: 180 nM) and CK2 (IC50: 230 nM). In triple-negative breast cancer (TNBC), BRD4/CK2-IN-1 induces apoptosis and autophagy-related cell death.

    价 格：￥电议型 号：T63991产 地：中国大陆

  • T63707BRD4-BD1/2-IN-2；化合物 BRD4-BD1/2-IN-2BRD4-BD1/2-IN-2

    BRD4-BD1/2-IN-2 is a potent inhibitor of BRD4-BD2, capable of acting on both BRD4 BD2 (IC50<0.5 nM) and BRD4 BD1 (IC50<300 nM).

    价 格：￥电议型 号：T63707产 地：中国大陆

  • T63471PARP1/BRD4-IN-1；化合物 PARP1/BRD4-IN-1PARP1/BRD4-IN-1

    PARP1/BRD4-IN-1 is a highly selective and potent inhibitor of PARP1 (IC50: 49 nM) and BRD4 (IC50: 202 nM).PARP1/BRD4-IN-1 inhibits the expression and activity of PARP1 and BRD4, thereby synergistically suppressing the malignant growth of pancreatic cancer cells.

    价 格：￥电议型 号：T63471产 地：中国大陆

  • T63352BRD4 Inhibitor-18；化合物 BRD4 Inhibitor-18BRD4 Inhibitor-18

    BRD4 Inhibitor-18 is a potent BRD4 inhibitor (IC50: 110 nM) with a hydrophobic acetylcyclopentane side chain. BRD4 Inhibitor-18 significantly reduces the proliferation of MV-4-11 cells with high BRD4 levels, inhibits G0/G1 cycle activity, and promotes apoptosis. The inhibition of G0/G1 cycle activity and apoptosis were also observed.

    价 格：￥电议型 号：T63352产 地：中国大陆

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