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  • T62521A2AAR/HDAC-IN-1；化合物 A2AAR/HDAC-IN-1A2AAR/HDAC-IN-1

    A2AAR/HDAC-IN-1 (compound 14c) is an orally active, balanced A2AAR/HDAC dual inhibitor of A2AAR (Ki: 163.5 nM), HDAC1 (IC50: 145.3 nM). effect.

    价 格：￥电议型 号：T62521产 地：中国大陆

  • T61962PARP-1/HDAC-IN-1；化合物 PARP-1/HDAC-IN-1PARP-1/HDAC-IN-1

    PARP-1/HDAC-IN-1 is an effective dual inhibitor of PARP-1/HDAC6, with IC50 of 68.90 nM and 510 nM respectively. PARP-1/HDAC-IN-1 has anti-cancer, anti-migration and anti-angiogenesis activities.

    价 格：￥电议型 号：T61962产 地：中国大陆

  • T61958MAO A/HDAC-IN-1；化合物 MAO A/HDAC-IN-1MAO A/HDAC-IN-1

    MAO A/HDAC-IN-1 is an effective monoamine oxidase A (MAO A) and HDAC dual inhibitor, which can be used for glioma research.

    价 格：￥电议型 号：T61958产 地：中国大陆

  • T61583CDK/HDAC-IN-1；化合物 CDK/HDAC-IN-1CDK/HDAC-IN-1

    CDK/HDAC-IN-1 exhibits potent inhibitory activity towards CDK2/4/6 and HDAC6, with IC50 values of 60.9 ± 2.9 nM, 276 ± 22.3 nM, 27.2 ± 4.2 nM, and 128.6 ± 0.4 nM, respectively.

    价 格：￥电议型 号：T61583产 地：中国大陆

  • T61537ASIC-IN-1；化合物 ASIC-IN-1ASIC-IN-1

    ASIC-IN-1 is a potent inhibitor of acid-sensing ion channels, demonstrating an IC 50 value of less than 10 μM. It effectively reduces pain intensity in a dose-dependent manner [1].

    价 格：￥电议型 号：T61537产 地：中国大陆

  • T61524Tubulin/HDAC-IN-1；化合物 Tubulin/HDAC-IN-1Tubulin/HDAC-IN-1

    Tubulin/HDAC-IN-1 is a compound that functions as a dual inhibitor for tubulin and HDAC-IN-1. It achieves this by interacting with tubulin through CH/π interaction and with HDAC8 through hydrogen bond interaction. This compound effectively inhibits tubulin polymerization and selectively targets HDAC8 with an IC50 of 150 nM. Additionally, Tubulin/HDAC-IN-1 demonstrates cytotoxicity against various human cancer cells, induces cell cycle arrest in the G2/M phase, and triggers cell apoptosis. This c

    价 格：￥电议型 号：T61524产 地：中国大陆

  • T61510PIM-1/HDAC-IN-1；化合物 PIM-1/HDAC-IN-1PIM-1/HDAC-IN-1

    PIM-1/HDAC-IN-1 (compound 4d) is a potent inhibitor of PIM-1, with an IC 50 of 343.87 nM. It also exhibits strong inhibitory activity and selectivity against HDAC 1 and HDAC 6, with IC 50 values of 63.65 and 62.39 nM, respectively. Furthermore, PIM-1/HDAC-IN-1 demonstrates apoptosis-inducing potential in MCF-7 cell lines, specifically inducing pre-G1 apoptosis and causing cell cycle arrest at the G2/M phase [1].

    价 格：￥电议型 号：T61510产 地：中国大陆

  • T61451NMDAR/HDAC-IN-1；化合物 NMDAR/HDAC-IN-1NMDAR/HDAC-IN-1

    NMDAR/HDAC-IN-1 (Compound 9d) is a potent dual inhibitor of N-methyl-D-aspartate receptors (NMDARs) and histone deacetylases (HDACs). It exhibits a high affinity (Ki = 0.59 μM) for NMDARs, while demonstrating significant inhibitory effects on various HDAC isoforms, including HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC 50 values of 2.67 μM, 8.00 μM, 2.21 μM, 0.18 μM, and 0.62 μM, respectively. Moreover, NMDAR/HDAC-IN-1 efficiently crosses the blood-brain barrier [1].

    价 格：￥电议型 号：T61451产 地：中国大陆

  • T60654KDM4C-IN-1；KDM4C抑制剂1KDM4C-IN-1

    KDM4C-IN-1 is a selective and potent KDM4C inhibitor (IC50: 8 nM) with potential anticancer activity.KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells, and can be used for the study of leukaemia.

    价 格：￥电议型 号：T60654产 地：中国大陆

  • T3964Glutaminase C-IN-1；化合物Glutaminase C-IN-1Compound 968|||Glutaminase Inhibitor Compound 968；Compound 9

    Glutaminase C-IN-1 (Compound 968) is a Glutaminase C allosteric inhibitor.

    价 格：￥电议型 号：T3964产 地：中国大陆

  • T28938Tec-IN-14；化合物 T28938Tec IN 14|||TecIN14|||TecIN14|||TecIN14|||Tec-IN-14；Tec IN 14|||TecIN14|||TecIN1

    Tec-IN-14 is a Tec kinase inhibitor. Tec-IN-14 blocks unconventional secretion of fibroblast growth factor 2 (FGF2).

    价 格：￥电议型 号：T28938产 地：中国大陆

  • T13242UbcH5c-IN-1；化合物 T13242UbcH5c-IN-1

    UbcH5c-IN-1 is a selective small-molecule Ubiquitin-conjugating enzyme UbcH5c inhibitor (Kd: 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85).

    价 格：￥电议型 号：T13242产 地：中国大陆

  • T13061T338C Src-IN-1；化合物 T13061T338C Src-IN-1

    T338C Src-IN-1 is a potent mutant-Src T338C inhibitor(T338C,IC50=111 nM relative to WT c-Src (10-fold increase)).

    价 格：￥电议型 号：T13061产 地：中国大陆

  • T12563PrPSc-IN-1；化合物 T12563PrPSc-IN-1

    PrPSc-IN-1 is a fluorescent probe, binds to the misfolded protein PrPSc, inhibits its accumulation(IC50 of 1.6 μM), with anti-prion activity.

    价 格：￥电议型 号：T12563产 地：中国大陆

  • T12494PKC-IN-1；化合物PKC-IN-1PKC-IN-1

    PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM, respectively).

    价 格：￥电议型 号：T12494产 地：中国大陆

  • T12455PI3K/HDAC-IN-1；化合物 T12455PI3K/HDAC-IN-1

    PI3K/HDAC-IN-1 is a potent PI3K and HDAC dual inhibitor(IC50s of 8.1 nM and 1.4 nM, respectively).

    价 格：￥电议型 号：T12455产 地：中国大陆

  • T11735K-Ras G12C-IN-1；化合物 T11735K-Ras G12C-IN-1

    K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.

    价 格：￥电议型 号：T11735产 地：中国大陆

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