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  • T78011Cyclic MKEY TFA；化合物 Cyclic MKEY TFACyclic MKEY TFA

    Cyclic MKEY TFA, a synthetic cyclic peptide, inhibits CXCL4-CCL5 heterodimer formation, thus guarding against atherosclerosis and aortic aneurysm by mitigating inflammation. Additionally, it affords protection against stroke-induced brain injury in mice [1] [2].

    价 格：￥电议型 号：T78011产 地：中国大陆

  • T76544Cyclic SSTR agonist octreotide；化合物 Cyclic SSTR agonist octreotideCyclic SSTR agonist octreotide

    Cyclic SSTR agonist octreotide is a Octreotide , serving as the cyclic Somatostatin Receptor SSTR agonist [1] .

    价 格：￥电议型 号：T76544产 地：中国大陆

  • T76017CTTHWGFTLC, CYCLIC TFA；化合物 CTTHWGFTLC, CYCLIC TFACTTHWGFTLC, CYCLIC TFA

    CTTHWGFTLC, also known as CYCLIC TFA, is a cyclic peptide that acts as an inhibitor of matrix metalloproteinases (MMP-2 and MMP-9), with an IC50 value of approximately 8 μM for MMP-9 [1].

    价 格：￥电议型 号：T76017产 地：中国大陆

  • T73362C-di-IMP；化合物 C-di-IMPCyclic-di-IMP；Cyclic-di-IMP

    Cyclic-di-IMP (C-di-IMP), a STING agonist, serves as a research tool in tumor studies.

    价 格：￥电议型 号：T73362产 地：中国大陆

  • T72243Cyclic-di-GMP diammonium；化合物 Cyclic-di-GMP diammonium5GP-5GP diammonium|||c-di-GMP diammonium ; cyc

    Cyclic di-GMP (c-di-GMP) diammonium is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species [1] [2] .

    价 格：￥电议型 号：T72243产 地：中国大陆

  • T64248Cyclic-di-GMP sodium；化合物 Cyclic-di-GMP sodiumCyclic-di-GMP sodium

    Cyclic di-GMP sodium (c-di-GMP sodium) is a STING activator and a ubiquitous second messenger that regulates biofilm formation, motility and virulence of various bacteria.

    价 格：￥电议型 号：T64248产 地：中国大陆

  • T6065Triciribine；曲西立滨VD-0002|||Tricyclic nucleoside|||NSC 154020|||API-2|||TCN；VD-0002|||Tricyclic nucleo

    Triciribine (NSC-154020) is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.

    价 格：￥电议型 号：T6065产 地：中国大陆

  • T60419Cyclic HPMPC；化合物 Cyclic HPMPCCyclic HPMPC

    Cyclic HPMPC is a potent antiviral agent that enhances arterial oxygen saturation in mice infected with the lethal vaccinia virus (IHD strain) and alleviates congenital guinea pig cytomegalovirus (GPCMV) infection outcomes by reducing viral replication in guinea pigs [1] [2].

    价 格：￥电议型 号：T60419产 地：中国大陆

  • T378038-bromo-Cyclic ADP-Ribose (sodium salt)；8-bromo-Cyclic ADP-Ribose (sodium salt)8-bromo-Cyclic ADP-Ri

    Cyclic ADP-ribose (cADP-ribose) is a calcium mobilizing nucleotide that is biosynthesized from NAD+ by cADP-ribose synthases, including CD38. cADP-Ribose appears to activate calcium channels in intracellular membranes, which in turn activate ryanodine receptors. 8-bromo-cADP-Ribose is a stable, cell-permeable analog that blocks calcium release evoked by cADP-ribose in sea urchin egg homogenates with an IC50 value of 1.7 μM. It is commonly used to investigate intracellular signaling through cADP-

    价 格：￥电议型 号：T37803产 地：中国大陆

  • T37687Cyclic ADP-ribose ammonium；Cyclic ADP-ribose ammoniumCyclic ADP-ribose ammonium

    Cyclic ADP-ribose ammonium (cADPR ammonium) is a powerful calcium mobilization second messenger synthesized from NAD+ by an ADP-ribosyl cyclase. It primarily raises cytosolic calcium levels through Ryanodine receptor-mediated release from the endoplasmic reticulum, while also facilitating extracellular influx through the opening of TRPM2 channels [1][2][3].

    价 格：￥电议型 号：T37687产 地：中国大陆

  • T37475Cyclic ADP-Ribose (ammonium salt)；Cyclic ADP-Ribose (ammonium salt)cADP-Ribose|||cADPR|||Cyclic ADP-

    Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second messenger is generated via the cADP-ribose synthases CD38 and CD157.[6],[5],[7] cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.[8]

    价 格：￥电议型 号：T37475产 地：中国大陆

  • T36985Cyclic di-UMP (sodium salt)；Cyclic di-UMP (sodium salt)Cyclic di-UMP (sodium salt)

    Cyclic di-UMP is a pyrimidine-containing cyclic dinucleotide (CDN).1It is produced by bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases), such as LpCdnE02 fromL. pneumophila, and binds to cGAS, in the apo or dsDNA-bound forms, with reduced affinity compared to 2´3´-cGAMP or 3´3´-cGAMP .1,2Cyclic di-UMP is intended for use as a negative control for cyclic di-GMP signaling.

    价 格：￥电议型 号：T36985产 地：中国大陆

  • T36984Cyclic di-IMP (sodium salt)；Cyclic di-IMP (sodium salt)Cyclic di-IMP (sodium salt)

    Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with antigens in vitro and by mucosal routes in vivo. C-di-IMP enriches the population of MHC class I and II, CD80, CD86, CD40, and CD54 positive dendritic cells derived from murine bone marrow. It also stimulates macrophages at 500 ng/ml. Mice immunized with β-galactosidase (β-gal) p

    价 格：￥电议型 号：T36984产 地：中国大陆

  • T36678Rp-8-CPT-cAMPS sodium；Rp-8-CPT-Cyclic AMP (sodium salt)Rp-8-CPT-cAMPS sodium

    Rp-8-CPT-cAMP is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs, 8-CPT-cyclic AMP and Rp-cyclic AMPS .[1] It functions as a site-selective inhibitor of protein kinase A (PKA) type I and II, with preference towards site A of type I and site B of type II.2 By occupying cAMP binding sites at the regulatory subunit of PKA, Rp-8-CPT-cAMP prevents the kinase holoenzyme from dissociative activation.[2],[3]

    价 格：￥电议型 号：T36678产 地：中国大陆

  • T36677Rp-8-bromo-Cyclic AMPS (sodium salt)；Rp-8-bromo-Cyclic AMPS (sodium salt)Rp-8-bromo-Cyclic AMPS (sod

    Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II

    价 格：￥电议型 号：T36677产 地：中国大陆

  • T36548Carbocyclic Thromboxane A2；Carbocyclic Thromboxane A2Carbocyclic Thromboxane A2

    Carbocyclic Thromboxane A2 can be used in related research in the field of life sciences. Its product number is T36548 and CAS number is 74034-56-3.

    价 格：￥电议型 号：T36548产 地：中国大陆

  • T3637Pifithrin-β hydrobromide；化合物Pifithrin-β hydrobromideCyclic PFT-α|||PFT-β|||Cyclic Pifithrin-α hydrob

    Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM).

    价 格：￥电议型 号：T3637产 地：中国大陆

  • T36330Terrecyclic Acid；Terrecyclic AcidTerrecyclic Acid

    Terrecyclic acid is a sesquiterpene originally isolated from A. terreus with antibiotic and anticancer activity. It is active against S. aureus, B. subtilis, and M. roseus (MICs = 25, 50, and 25 μg/ml, respectively). Terrecyclic acid induces a heat shock response, increases levels of reactive oxygen species (ROS), and inhibits NF-κB activity and cell growth in 3T3-Y9-B12 cells.

    价 格：￥电议型 号：T36330产 地：中国大陆

  • T35595Cyclic di-AMP (sodium salt)；Cyclic di-AMP (sodium salt)Cyclic di-AMP (sodium salt)

    Cyclic di-AMP (c-di-AMP) is a second messenger produced by bacteria but not by mammals. Generated by a family of diadenylate cyclases, c-di-AMP can impact bacterial cell growth, cell wall homeostasis, pathogenicity, and other cellular functions. Bacteria-derived cyclic dinucleotides, including c-di-AMP, trigger the expression of interferon genes in mammalian cells.

    价 格：￥电议型 号：T35595产 地：中国大陆

  • T354248-bromo-Cyclic AMP；8-bromo-Cyclic AMP8-bromo-Cyclic AMP

    8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase. It can activate cAMP-dependent protein kinase, inhibiting growth, decreasing proliferation, increasing differentiation, and inducing apoptosis of cancer cells.

    价 格：￥电议型 号：T35424产 地：中国大陆

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