HSP90(第2页)_上海陶术生物科技有限公司

T63827HSP90-IN-10；化合物 HSP90-IN-10HSP90-IN-10

HSP90-IN-10 is a potent inhibitor of HSP90. HSP90-IN-10 exhibits potent anti-proliferative effects on HCC1954 breast cancer cells (IC50: 6 μM). hSP90-IN-10 induces apoptosis without inhibiting the growth of normal epithelial cells.

价格：￥电议型号：T63827产地：中国大陆
T63531HDAC6/HSP90-IN-1；化合物 HDAC6/HSP90-IN-1HDAC6/HSP90-IN-1

HDAC6/HSP90-IN-1 is a potent and selective dual inhibitor of HDAC6 (IC50: 4.3 nM) and HSP90 (IC50: 46.8 nM).HDAC6/HSP90-IN-1 downregulates PD-L1 expression in INF-γ-treated H1975 lung cancer cells.HDAC6/HSP90-IN-1 exhibits tumor growth inhibition in H1975 xenograft mice.HDAC6/HSP90-IN-1 is a potent and selective dual inhibitor of HDAC6 (IC50: 4.3 nM) and HSP90 (IC50: 46.8 nM). 1 exhibited tumor growth inhibition in H1975 xenograft mice.

价格：￥电议型号：T63531产地：中国大陆
T63529HDAC/HSP90-IN-3；化合物 HDAC/HSP90-IN-3HDAC/HSP90-IN-3

HDAC/HSP90-IN-3 is a selective and potent dual inhibitor of fungal Hsp90 (IC50: 0.83 μM) and HDAC (IC50: 0.91 μM), exhibiting antifungal effects against azole-resistant Candida albicans. HDAC/HSP90-IN-3 exhibits inhibitory effects on important virulence factors and is able to downregulate the resistance genes ERG11 and CDR1.

价格：￥电议型号：T63529产地：中国大陆
T63528HSP90-IN-11；化合物 HSP90-IN-11HSP90-IN-11

HSP90-IN-11 is a potent inhibitor of HSP90 and induces significant accumulation of the sub-G1 population. HSP90-IN-11 has a potent HSP90α inhibitory effect comparable to that of AUY-922 (Luminespib). In CRC and NSCLC cells, HSP90-IN-11 exhibited significant anti-proliferative activity in the double-digit nM range.HSP90-IN-11 was able to rapidly degrade client proteins EGFR and Akt in NSCLC cells.

价格：￥电议型号：T63528产地：中国大陆
T63205HSP90-IN-13；化合物 HSP90-IN-13HSP90-IN-13

HSP90-IN-13 (compound 5k) is a potent broad-spectrum inhibitor of HSP90 with an IC50 of 25.07 nM. HSP90-IN-13 has multitargeted activity against EGFR, VEGFR-2 and Topoisomerase-2. HSP90-IN-13 blocks the MCF-7 cell cycle in G2/M HSP90-IN-13 blocks the MCF-7 cell cycle in G2/M phase and induces apoptosis through a mitochondria-mediated pathway.

价格：￥电议型号：T63205产地：中国大陆
T62307Aha1/Hsp90-IN-1；化合物 Aha1/Hsp90-IN-1Aha1/Hsp90-IN-1

Aha1/Hsp90-IN-1 (Compound 17) is an inhibitor of the Aha1/Hsp90 complex and has an inhibitory effect on tau protein aggregation.Aha1/Hsp90-IN-1 disrupts the Aha1/Hsp90 interaction (IC50: 3.32 μM).

价格：￥电议型号：T62307产地：中国大陆
T62163Hsp90-IN-15；化合物 Hsp90-IN-15Hsp90-IN-15

Hsp90-IN-15 is an Hsp90 inhibitor with anticancer effects. Hsp90-IN-15 blocks the cell cycle in S phase, induces apoptosis and reduces Hsp90 expression in Hela cells.

价格：￥电议型号：T62163产地：中国大陆
T61938HSP90-IN-12；化合物 HSP90-IN-12HSP90-IN-12

Vibsanin A analog C (VAC) is an anti-cancer compound, which shows anti-proliferative effect on various cancer cell lines, and the anti-proliferative activity is the strongest among vibsanin A analogues. VAC fluctuated the amount of HSP90-related proteins in cells and showed an inhibitory effect on HSP90-mediated luciferase refolding in vitro.

价格：￥电议型号：T61938产地：中国大陆
T61904HSP90-IN-14；化合物 HSP90-IN-14HSP90-IN-14

HSP90-IN-14 (compound 4) is an effective Hsp90 inhibitor (Kd=0.26 μM). In MDCK cells, HSP90-IN-14 showed anti-influenza virus activity, the EC50 against influenza A/H3N2, A/H1N1 and B virus was 2.6, 3.9 and 17 μM, respectively.

价格：￥电议型号：T61904产地：中国大陆
T61315HDAC6/HSP90-IN-2；化合物 HDAC6/HSP90-IN-2HDAC6/HSP90-IN-2

HDAC6/HSP90-IN-2 (compound 6e) is a dual inhibitor targeting HDAC6 and Hsp90, exhibiting IC50 values of 105.7 nM and 61 nM, respectively. It is primarily utilized in cancer research [1].

价格：￥电议型号：T61315产地：中国大陆
T27991MDK-0757；化合物 T27991Hsp90-IN-89|||MDK0757；Hsp90-IN-89|||MDK0757

MDK-0757 is a novel inhibitor of heat shock protein 90 (Hsp90).

价格：￥电议型号：T27991产地：中国大陆
T13725Hsp90-Cdc37-IN-1；化合物 T13725Hsp90-Cdc37-IN-1

Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor (IC50: 140 nM) that inhibit cell migration and reverse drug resistance.

价格：￥电议型号：T13725产地：中国大陆

12共2页

企业档案

已获得易推广信誉 等级评定

自主品牌

已选条件

快速导航

已获得易推广信誉等级评定