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  • T78696Nrf2 activator-7；化合物 Nrf2 activator-7Nrf2 activator-7

    Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.

    价 格：￥电议型 号：T78696产 地：中国大陆

  • T78650Nrf2 activator-3；Nrf2 激活剂3Nrf2 activator-3

    Nrf2 activator-3 is a potent Nrf2 activator with potential anti-inflammatory, antioxidant and anti-tumor activity, which can be used to study neurological and immune-related diseases.

    价 格：￥电议型 号：T78650产 地：中国大陆

  • T74600Keap1-Nrf2-IN-9；化合物 Keap1-Nrf2-IN-9Keap1-Nrf2-IN-9

    Keap1-Nrf2-IN-9 (compound 11) is a potent inhibitor of the Keap1-Nrf2 protein?protein interaction (PPI) with an IC50 value of 0.575 ?M. It enhances the expression of Nrf2 target genes, including heme oxygenase 1 (Hmox1), glutathione S-transferase P (GstP), and glutamate-cysteine ligase catalytic (Gclc) and modulatory (Gclm) subunits. Notably, Keap1-Nrf2-IN-9 is not cytotoxic to ARPE19 cells [1].

    价 格：￥电议型 号：T74600产 地：中国大陆

  • T72827Nrf2/HO-1-IN-1；化合物 Nrf2/HO-1-IN-1Nrf2/HO-1-IN-1

    Nrf2/HO-1-IN-1 is a potent Nrf2/HO-1 pathway inhibitor, with an IC 50 value of 0.38 μM for NO . Nrf2/HO-1-IN-1 can significantly reduce the level of ROS in cells. Nrf2/HO-1-IN-1 can be used for researching anti-inflammatory [1] .

    价 格：￥电议型 号：T72827产 地：中国大陆

  • T72760Keap1-Nrf2-IN-6；化合物 Keap1-Nrf2-IN-6Keap1-Nrf2-IN-6

    Keap1-Nrf2-IN-6 is a potent, selective inhibitor of the Keap1-Nrf2 protein?protein interaction (PPI), demonstrating an inhibitory concentration (IC50) of 41 nM and a dissociation constant (Kd) of 68 nM.

    价 格：￥电议型 号：T72760产 地：中国大陆

  • T72706Keap1-Nrf2-IN-13；化合物 Keap1-Nrf2-IN-13Keap1-Nrf2-IN-13

    Keap1-Nrf2-IN-13 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI), exhibiting an IC50 value of 0.15 μM, indicative of its high efficacy. It binds strongly to the Keap1 protein by forming hydrogen bonds with critical polar residues (Asn414, Arg415, Arg483, Gln530), showcasing its specificity. This compound has implications for research into diseases associated with oxidative stress and inflammation, such as pulmonary fibrosis, chronic obstructive pulmonary disorder (COPD)

    价 格：￥电议型 号：T72706产 地：中国大陆

  • T72697Nrf2 activator-6；化合物 Nrf2 activator-6Nrf2 activator-6

    Nrf2 Activator-6, a tetrahydroisoquinoline compound, functions as an Nrf2 activator, demonstrating potency with an IC50 value of 5 nM in inhibiting the Kelch domain-Nrf2 interaction.

    价 格：￥电议型 号：T72697产 地：中国大陆

  • T72687Keap1-Nrf2-IN-11；化合物 Keap1-Nrf2-IN-11Keap1-Nrf2-IN-11

    Keap1-Nrf2-IN-11 (Compound 6k), a potent Keap1-Nrf2 inhibitor, exhibits a dissociation constant (KD) of 0.21 nM. It hampers the production of reactive oxygen species (ROS) and nitric oxide (NO), as well as the expression of tumor necrosis factor-alpha (TNF-α). By promoting Nrf2 nuclear translocation, it mitigates inflammation and is utilized in anti-inflammatory studies [1].

    价 格：￥电议型 号：T72687产 地：中国大陆

  • T72417AChE/Nrf2 modulator 1；化合物 AChE/Nrf2 modulator 1AChE/Nrf2 modulator 1

    AChE/Nrf2 modulator 1, an orally active compound, serves as a modulator of acetylcholinesterase (AChE) and nuclear factor erythroid 2-related factor 2 (Nrf2). It exhibits Nrf2 inductive activity alongside inhibitory effects on eeAChE and hAChE, demonstrating IC 50 values of 0.07 μM and 0.38 μM, respectively. This compound is applicable in Alzheimer´s disease research.

    价 格：￥电议型 号：T72417产 地：中国大陆

  • T64218Keap1-Nrf2-IN-1 TFA；化合物 Keap1-Nrf2-IN-1 TFAKeap1-Nrf2-IN-1 TFA

    Keap1-Nrf2-IN-1 TFA (compound35) is a Keap1-Nrf2 protein-protein interaction inhibitor (IC50: 43 nM) that activates Nrf2-regulated cytoprotective responses. Keap1-Nrf2-IN-1 TFA antagonizes acetaminophen-induced liver injury in cellular and in vivo models.

    价 格：￥电议型 号：T64218产 地：中国大陆

  • T64190Keap1-Nrf2-IN-12；化合物 Keap1-Nrf2-IN-12Keap1-Nrf2-IN-12

    eap1-Nrf2-IN-12 is a potent inhibitor of Keap1-Nrf2 (IC50: 2.30 μM). eap1-Nrf2-IN-12 is metabolically stable in human liver microsomes.

    价 格：￥电议型 号：T64190产 地：中国大陆

  • T63987Keap1-Nrf2-IN-14；化合物 Keap1-Nrf2-IN-14Keap1-Nrf2-IN-14

    Keap1-Nrf2-IN-14 is a KEAP1-NRF2 inhibitor that effectively disrupts the KEAP1-NRF2 interaction (IC50: 75 nM) with a Kd=24 nM for KEAP1. Keap1-Nrf2-IN-14 induces the expression of NRF2 target genes and is able to enhance downstream antioxidant and anti-inflammatory effects. -Nrf2-IN-14 can be used to study oxidative stress-related inflammation.

    价 格：￥电议型 号：T63987产 地：中国大陆

  • T63364Nrf2 activator-5；化合物 Nrf2 activator-5Nrf2 activator-5

    Nrf2 activator-5 is a potent activator of Nrf2 that attenuates H2O2-induced oxidative stress and LPS-stimulated inflammation in BV-2 microglia, exhibiting antioxidant and anti-inflammatory activity.

    价 格：￥电议型 号：T63364产 地：中国大陆

  • T63294Keap1-Nrf2-IN-5；化合物 Keap1-Nrf2-IN-5Keap1-Nrf2-IN-5

    Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).

    价 格：￥电议型 号：T63294产 地：中国大陆

  • T63016Nrf2 activator-4；Nrf2 激活剂4Nrf2 activator-4

    Nrf2 activator-4 is an Nrf2 activator that inhibits the production of reactive oxygen species in microglia for the treatment of fatty liver disease associated with metabolic dysfunction in humans.

    价 格：￥电议型 号：T63016产 地：中国大陆

  • T61773Keap1-Nrf2-IN-4；化合物 Keap1-Nrf2-IN-4Keap1-Nrf2-IN-4

    Keap1-Nrf2-IN-4, a powerful neddylation inhibitor, demonstrates significant anti-proliferation activity against MGC-803 cells (IC50 = 2.55 μM), effectively impeding their migration and inducing apoptosis. Additionally, it effectively inhibits tumor growth while exhibiting minimal toxicity [1].

    价 格：￥电议型 号：T61773产 地：中国大陆

  • T61688Nrf2 activator-2；化合物 Nrf2 activator-2Nrf2 activator-2

    Nrf2 activator-2 (referred to as compound O15), an Osthole derivative, is a highly potent Nrf2 agonist exhibiting an EC 50 of 2.9 μM in 293 T cells. By effectively disrupting the binding between Keap1 and Nrf2, Nrf2 activator-2 activates the Nrf2 pathway. Furthermore, this compound significantly reduces the ubiquitination of Nrf2 in cells, indicating its potential in regulating Nrf2 activity [1].

    价 格：￥电议型 号：T61688产 地：中国大陆

  • T61522Nrf2/HO-1 activator 2；化合物 Nrf2/HO-1 activator 2Nrf2/HO-1 activator 2

    Nrf2/HO-1 activator 2 (compound 13m), a difluoro-substituted derivative, is a highly potent activator of Nrf2/HO-1. It exhibits substantial neuroprotective and antioxidant properties by activating the Nrf2/HO-1 pathway through phosphorylation of ERK1/2, JNK, or Akt in PC12 cells. This compound finds utility in the investigation of Parkinson´s disease (PD) [1].

    价 格：￥电议型 号：T61522产 地：中国大陆

  • T61205Nrf2/HO-1 activator 1；化合物 Nrf2/HO-1 activator 1Nrf2/HO-1 activator 1

    Nrf2/HO-1 activator 1 (Compound 24) is a potent neuroprotective agent with significant antioxidant activities, specifically targeting Nrf2/HO-1. It is particularly useful in Parkinson´s disease (PD) research, illustrating its potential in therapeutic applications [1].

    价 格：￥电议型 号：T61205产 地：中国大陆

  • T60395Nrf2-ARE/hMAO-B/QR2 modulator 1；化合物 Nrf2-ARE/hMAO-B/QR2 modulator 1Nrf2-ARE/hMAO-B/QR2 modulator 1

    Nrf2-ARE/hMAO-B/QR2 modulator 1 is a new resveratrol-based multitarget-directed ligands (MTDLs) that showed a well-balanced MTDL profile: cellular activation of the NRF2-ARE pathway (CD = 9.83 μM), selective inhibition of both hMAO-B and QR2 (IC50s = 8.05 and 0.57 μM), and the best ability to promote hippocampal neurogenesis. Nrf2-ARE/hMAO-B/QR2 modulator 1 exerts neuroprotective and antioxidant actions in both acute and chronic Alzheimer models using hippocampal tissues.

    价 格：￥电议型 号：T60395产 地：中国大陆

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