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  • T77943SJ1008030 TFA;化合物 SJ1008030 TFASJ1008030 TFA

    SJ1008030 (compound 8) TFA is a selective JAK2-degrading PROTAC that inhibits the growth of MHH-CALL-4 leukemia cells with an IC50 of 5.4 nM, indicating its potential use for leukemia research [1].

    价 格:¥电议型 号:T77943产 地:中国大陆

  • T77933SJ995973;化合物 SJ995973SJ995973

    SJ995973 (PROTAC) represents a highly efficacious degrader of bromodomain and extra-terminal (BET) proteins.

    价 格:¥电议型 号:T77933产 地:中国大陆

  • T77923BSJ-03-204 triTFA;化合物 BSJ-03-204 triTFABSJ-03-204 triTFA

    BSJ-03-204 triTFA is a potent and selective Cereblon- and CDK-targeted PROTAC (PROteolysis TArgeting Chimera) featuring Palbociclib-based ligands for the degradation of CDK4/6. It exhibits IC50 values of 26.9 nM for CDK4/D1 and 10.4 nM for CDK6/D1, indicating strong inhibitory capabilities. Notably, it spares IKZF1/3 from degradation and possesses anti-cancer activity [1].

    价 格:¥电议型 号:T77923产 地:中国大陆

  • T7678SJB2-0432-苯基萘并[2,3-D]恶唑-4,9-二酮2-苯基萘并[2,3-D]恶唑-4,9-二酮

    SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).

    价 格:¥电议型 号:T7678产 地:中国大陆

  • T74994SJ988497;化合物 SJ988497SJ988497

    SJ988497 is a PROTAC JAK2 degrader that effectively inhibits proliferation in CRLF2-rearranged (CRLF2r) cells and facilitates the degradation of the CRBN neosubstrate GSPT1. Composed of a Ruxolitinib derivative, a linker, and the CRBN ligand Pomalidomide, SJ988497 is utilized in researching acute lymphoblastic leukemia (ALL) [1].

    价 格:¥电议型 号:T74994产 地:中国大陆

  • T74580SJ1008030;化合物 SJ1008030SJ1008030

    SJ1008030 (compound 8), a JAK2 PROTAC, selectively degrades JAK2. It demonstrates potent activity against MHH–CALL-4 cells, with an EC50 of 5.4 nM and an IC50 of 32.09 nM. This compound holds potential for leukemia research [1].

    价 格:¥电议型 号:T74580产 地:中国大陆

  • T74429SJ10542;化合物 SJ10542SJ10542

    SJ10542, a phenyl glutarimide (PG)-PROTAC, demonstrates potent and selective activity against JAK2/3 by exhibiting DC50 values of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. It employs a PG ligand for cereblon (CRBN) recruitment [1].

    价 格:¥电议型 号:T74429产 地:中国大陆

  • T74002SJF620 hydrochloride;化合物 SJF620 hydrochlorideSJF620 hydrochloride

    SJF620 hydrochloride is a PROTAC that utilizes a lenalidomide analog to recruit CRBN and ligands to target Btk, exhibiting a DC50 of 7.9 nM [1].

    价 格:¥电议型 号:T74002产 地:中国大陆

  • T73182BSJ-04-122;化合物BSJ-04-122BSJ-04-122

    BSJ-04-122 is a covalent MKK4/7 dual inhibitor that inhibits MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, respectively.BSJ-04-122 can be used for cancer research.

    价 格:¥电议型 号:T73182产 地:中国大陆

  • T71864SJ572710;化合物 SJ572710SJ572710

    SJ572710 is an inhibitor of the disordered protein, p27(Kip1).

    价 格:¥电议型 号:T71864产 地:中国大陆

  • T71056SJP-L-5;化合物 SJP-L-5SJP-L-5

    SJP-L-5 is a inhibitor of HIV-1 infection by blocking viral DNA nuclear entry.

    价 格:¥电议型 号:T71056产 地:中国大陆

  • T70948Sjc 13;化合物 Sjc 13Sjc 13

    Sjc 13 is an azaindolidine derivative that is a cell adhesion molecule inhibitor.

    价 格:¥电议型 号:T70948产 地:中国大陆

  • T63841BSJ-01-175;化合物 BSJ-01-175BSJ-01-175

    BSJ-01-175 is a selective and potent covalent inhibitor of CDK12/13. BSJ-01-175 is significantly selective for cancer cells, exhibits potent inhibition of phosphorylated RNA polymerase II, and significantly downregulates CDK12 target genes.

    价 格:¥电议型 号:T63841产 地:中国大陆

  • T6337RepSox;化合物RepSoxALK5 Inhibitor II|||SJN 2511|||E-616452;ALK5 Inhibitor II|||SJN 2511|||E-616452

    RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). RepSox induces adipogenesis in MEFs cells.

    价 格:¥电议型 号:T6337产 地:中国大陆

  • T63156SJ000025081;化合物 SJ000025081SJ000025081

    SJ000025081 is a dihydropyridine and can be used as an antimalarial agent. In a mouse malaria model, SJ000025081 significantly inhibited parasitemia in P. yoelii infection.

    价 格:¥电议型 号:T63156产 地:中国大陆

  • T60644SJ000063181;化合物SJ000063181SJ000063181

    SJ000063181 is a potent activator of BMP signaling, exhibiting an EC50 of ≤1 μM. It serves as a valuable chemical probe for BMP signaling analysis, owing to its ability to penetrate zebrafish embryos.

    价 格:¥电议型 号:T60644产 地:中国大陆

  • T5536SJA710-6;化合物SJA710-6SJA710-6

    SJA710-6 is able to selectively differentiate MSCs toward hepatocyte-like cells.

    价 格:¥电议型 号:T5536产 地:中国大陆

  • T5395BSJ-03-123;化合物BSJ-03-123BSJ-03-123

    BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.

    价 格:¥电议型 号:T5395产 地:中国大陆

  • T4662SJ000291942;化合物SJ000291942SJ000291942

    SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.

    价 格:¥电议型 号:T4662产 地:中国大陆

  • T41257SJ6986;化合物SJ6986SJ6986

    SJ6986 is a potent, selective and orally active GSPT1/2 degrader. SJ6986 degrades GSPT1 with a DC 50 of 2.1 nM (D max 99%) [1].

    价 格:¥电议型 号:T41257产 地:中国大陆

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