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T2454DacinostatLAQ-824,Dacinostat,Histone deacetylases,inhibit,Autophagy,HDAC,Inhibitor,LAQ 824
LAQ824 (Dacinostat) is a novel HDAC inhibitor with IC50 of 32 nM and is an activator of the p21 promoter.
价 格：￥电议型 号：T2454产 地：中国大陆
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TL0008Gigantolinhibit,Wnt,Gigantol,Inhibitor
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a promising neuroprotective agent for successful MSC transplantation in ischemic diseases, it shows the protective effect against hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.Gigantol inhibits aldose reductase gene to e
价 格：￥电议型 号：TL0008产 地：中国大陆
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TL00053,5-O-Dicaffeoylquinic acidInhibitor,inhibit,3,5ODicaffeoylquinic acid,3,5 O Dicaffeoylquinic acid
3,5-Dicaffeoylquinic acid is an isolated compound from Artemisia argyi; its ester derivatives exert anti-leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and potential anti-giardial effects. 3,5-di-O-caffeoylquinic acid as a neuraminidase inhibitory ligand in Flos Lonicerae, it has neuroprotective effects on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1. 3,5-di-O-caffeoylquinic acid also has antioxidant and anti-complementary acti
价 格：￥电议型 号：TL0005产 地：中国大陆
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T8503TLR4-IN-C34TLR4 IN C34,Toll-like Receptor (TLR),Inhibitor,TLR4INC34,inhibit,TLR-4-IN-C34
TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis
价 格：￥电议型 号：T8503产 地：中国大陆
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T6614Nutlin-3bNutlin 3b,Inhibitor,MDM-2/p53,Ubiquitin activating enzyme,Ubiquitin conjugating enzyme,inhi
Nutlin-3b is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.
价 格：￥电议型 号：T6614产 地：中国大陆
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TQ0237LemborexantLemborexant,OX1R,Orexin Receptor (OX Receptor),CNS,competitive,inhibit,CYP3A4,E2006,Hypoc
Lemborexant is a reversible and orally active dual antagonist of the orexin OX1 and OX2 receptors (IC50s: 6.1 nM and 2.6 nM).
价 格：￥电议型 号：TQ0237产 地：中国大陆
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T6736ZafirlukastLeukotriene Receptor,Zafirlukast,ICI-204219,Inhibitor,inhibit,ICI204219
Zafirlukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma.
价 格：￥电议型 号：T6736产 地：中国大陆
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T9287HydroxychloroquineParasite,Toll-like Receptor (TLR),SARS-CoV,Inhibitor,SARS coronavirus,Autophagy,Hy
Hydroxychloroquine (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It is a medication used to prevent and treat malaria, and it´s also being studied as an experimental treatment for COVID-19.
价 格：￥电议型 号：T9287产 地：中国大陆
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T7860SM-324405Inhibitor,Toll-like Receptor (TLR),low toxicity,TLR7,SM-324405,cytokine,diseases,immunother
SM 324405 is an agonist of TLR7.
价 格：￥电议型 号：T7860产 地：中国大陆
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TL0007Bisdemethoxycurcumininhibit,Inhibitor,Bisdemethoxycurcumin,antiinflammatory,curcuminoid,antioxidant,
Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expres
价 格：￥电议型 号：TL0007产 地：中国大陆
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T6964ResiquimodHepatitis C virus,R-848,S-28463,R 848,S 28463,Toll-like Receptor (TLR),Inhibitor,Resiquimo
Resiquimod is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and activating TLR7 and 8 mainly on dendritic cells, macrophages, and B-lymphocytes. This induces the nuclear translocation of the transcription activator NF-kB as well as activation of other transcription factors. This may lead to an increase in mRNA levels and subsequent production of cytokin
价 格：￥电议型 号：T6964产 地：中国大陆
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T7302CU-CPT9binhibit,Toll-like Receptor (TLR),CU-CPT9b,Inhibitor,CUCPT9b,CU CPT9b
CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.
价 格：￥电议型 号：T7302产 地：中国大陆
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T7347CU-CPT-8mCU CPT 8m,inhibit,Toll-like Receptor (TLR),CUCPT8m,Inhibitor
CU-CPT-8m is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
价 格：￥电议型 号：T7347产 地：中国大陆
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T8450TCN 213glycine-dependentlly,Inhibitor,Ionotropic glutamate receptors,inhibit,iGluR,surmountable,TCN-
TCN213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B
价 格：￥电议型 号：T8450产 地：中国大陆
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T8845UTL-5gliver,inhibit,Inhibitor,chemoprotective,Tumor Necrosis Factor Receptor,radioprotective,acute,t
UTL-5g is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hematotoxicity. It lowers elevated levels of AST, ALT, creatinine, BUN, and TNF-α, increases the reduced platelet count in mice, and acts as a novel chemo- and radioprotective agent.
价 格：￥电议型 号：T8845产 地：中国大陆
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TL0013HeracleninHeraclenin,inhibit,Inhibitor
Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it has a strong clastogenic effect . (+)-Heraclenin displays significant levels of antiplasmodial and moderate levels of antimicrobial activities.
价 格：￥电议型 号：TL0013产 地：中国大陆
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T6898MotolimodMotolimod,inhibit,VTX378,VTX 378,Inhibitor,Toll-like Receptor (TLR),VTX 2337,VTX2337
Motolimod (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.
价 格：￥电议型 号：T6898产 地：中国大陆
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TL0009coniferinInhibitor,Laricin,inhibit,coniferin,Fungal
Coniferin has ATP-dependent transport activity and has anti-oxidation effects. Coniferin has preferred substrates for the coniferin beta-glucosidase, the chromogenic coniferin analogue show the exclusive presence of beta-glucosidase activity in the differentiating xylem, similar to peroxidase activity.
价 格：￥电议型 号：TL0009产 地：中国大陆
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TN2008OkaninToll-like Receptor (TLR),Nuclear factor-κB,NF-κB,Inhibitor,Nuclear factor-kappaB,Okanin,inhibi
Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
价 格：￥电议型 号：TN2008产 地：中国大陆
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T7092NADPH tetrasodium saltlipid,NADPH tetrasodium,NADPH tetrasodium salt,pathways,fatty,Endogenous Metab
NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate (NADP+) and acts as an electron donor in various biological reactions.
价 格：￥电议型 号：T7092产 地：中国大陆
