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  • T14882CB30865CB30865,ZM 242421,

    CB30865 is a potent inhibitor of Nampt, an enzyme present in the NAD biosynthetic pathway.

    价 格：￥电议型 号：T14882产 地：美洲

  • T1754ZM 306416ZM 306416,CB 676475,

    ZM 306416, a VEGFR1 inhibitor (IC50: 0.33 μM), can also inhibit EGFR (IC50<10 nM).

    价 格：￥电议型 号：T1754产 地：美洲

  • T1851ZM 336372ZM 336372,Zinc00581684,

    ZM 336372 is a potent and selective c-Raf inhibitor.

    价 格：￥电议型 号：T1851产 地：美洲

  • T2146FulvestrantFulvestrant,ZD 9238,ZM 182780

    Fulvestrant is a potent Estrogen Receptor antagonist (IC50: 9.4 nM).

    价 格：￥电议型 号：T2146产 地：美洲

  • T2464NSC319726NSC319726,ZMC1,

    NSC319726, a mutant p53R175 reactivator, suppresses growth of fibroblasts that expresses the p53R175 mutation (IC50 = 8 nM).

    价 格：￥电议型 号：T2464产 地：美洲

  • T5605EZM 2302EZM 2302,GSK3359088,

    EZM2302 is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).

    价 格：￥电议型 号：T5605产 地：美洲

  • T6145ZM 39923 HClZM 39923 HCl,JAK3 Inhibitor IV,

    ZM 39923 HCl is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.

    价 格：￥电议型 号：T6145产 地：美洲

  • T79776ZZM-1220；化合物 ZZM-1220ZZM-1220

    ZZM-1220, a covalent inhibitor of histone lysine methyltransferase G9a/GLP, exhibits IC50 values of 458 nM for G9a and 924 nM for GLP. It effectively inhibits H3K9me2 in cells, induces apoptosis in triple-negative breast cancer (TNBC) cells, and arrests the cell cycle at the G2/M phase [1].

    价 格：￥电议型 号：T79776产 地：中国大陆

  • T79369ZMF-23；化合物 ZMF-23ZMF-23

    ZMF-23, a PAK1/HDAC6 dual inhibitor, suppresses PAK1 and HDAC6-mediated aerobic glycolysis and cellular migration while inducing TNF-α-regulated necroptosis and augmenting apoptosis. The compound effectively hampers the Warburg effect and cell motility, positioning it as a potential research tool for triple-negative breast cancer (TNBC) [1].

    价 格：￥电议型 号：T79369产 地：中国大陆

  • T73511SZM679；化合物 SZM679SZM679

    SZM679 is an orally active, selective RIPK1 inhibitor displaying potent affinity with a dissociation constant (Kd) of 8.6 nM for RIPK1, while exhibiting minimal activity towards RIPK3, with a Kd of >5000 nM. It effectively counteracts tumor necrosis factor-induced systemic inflammation, reduces Tau hyperphosphorylation, diminishes neuroinflammation, and lowers RIPK1 phosphorylation in the hippocampus and cortex. SZM679 is utilized in Alzheimer’s disease (AD) research [1].

    价 格：￥电议型 号：T73511产 地：中国大陆

  • T73382SZM-1209；化合物 SZM-1209SZM-1209

    SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant (Kd) of 85 nM. It demonstrates substantial anti-necroptotic efficacy with an EC50 of 22.4 ± 8.1 nM and possesses therapeutic effects against systemic inflammatory response syndrome (SIRS) and acute lung injury (ALI) [1].

    价 格：￥电议型 号：T73382产 地：中国大陆

  • T72956Darizmetinib；化合物 DarizmetinibHRX-0215；HRX-0215

    Darizmetinib (HRX-0215) is an MKK4 inhibitor. Inhibition of MKK4 leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration.

    价 格：￥电议型 号：T72956产 地：中国大陆

  • T72306Mycobacterial Zmp1-IN-1；化合物 Mycobacterial Zmp1-IN-1Mycobacterial Zmp1-IN-1

    Mycobacterial Zmp1-IN-1, a zinc metalloprotease-1 (Zmp1) inhibitor, demonstrates dose-dependent anti-mycobacterial activity against Mtb H37Ra, making it suitable for tuberculosis (TB) research.

    价 格：￥电议型 号：T72306产 地：中国大陆

  • T70801ZM-181037；化合物 ZM-181037ZM-181037

    ZM-181037 is an ATP-sensitive potassium channel-blocker and a eukalemic diuretic.

    价 格：￥电议型 号：T70801产 地：中国大陆

  • T7021ZM241385；化合物ZM241385ZM241385

    ZM-241385 is a high-affinity antagonist ligand selective for the adenosine A2A receptor.

    价 格：￥电议型 号：T7021产 地：中国大陆

  • T64019ZM514；化合物 ZM514ZM514

    ZM514 is a potent inhibitor of CD73, acting on hCD73 (IC50: 1.39 μM) and mCD73 (IC50: 14.65 μM). zM514 has low cytotoxicity and can be used in anti-cancer studies.

    价 格：￥电议型 号：T64019产 地：中国大陆

  • T63800ZM223 hydrochloride；化合物 ZM223 hydrochlorideZM223 hydrochloride

    ZM223 hydrochloride is a potent, non-covalent, orally active inhibitor of NEDD8 activase (NAE).

    价 格：￥电议型 号：T63800产 地：中国大陆

  • T63063ZMF-10；化合物 ZMF-10ZMF-10

    ZMF-10 is a potent inhibitor of PAK1, and can act on PAK1 (IC50:174 nM), PAK2 (IC50:1.038 μM) and PAK3 (IC50:1.372 μM). ZMF-10 inhibited PAK1 activity and affected Pak1-regulated apoptosis, endoplasmic reticulum stress and migration in MDA-MB-231 cells. ZMF-10 can be used to study cancer.

    价 格：￥电议型 号：T63063产 地：中国大陆

  • T6145ZM39923 hydrochloride化合物ZM 39923 HClJAK3 Inhibitor IV|||ZM 39923 HCl

    ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.

    价 格：￥电议型 号：T6145产 地：中国大陆

  • T6077ZM-447439；化合物ZM 447439ZM-447439

    ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.

    价 格：￥电议型 号：T6077产 地：中国大陆

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