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T79915Antioxidant agent-15;化合物 Antioxidant agent-15Antioxidant agent-15
Antioxidant agent-15 (Compound 4) demonstrates potent antioxidant inhibition activity, exhibiting an IC50 value of 15.44 nM. Furthermore, it effectively inhibits tumor cell growth in Hela, Hep G2, and Caco-2 cells, with respective IC50 values of 395.26 nM, 400.4 nM, and 24.6 nM [1].
价 格:¥电议型 号:T79915产 地:中国大陆
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T79582Antitumor agent-116;化合物 Antitumor agent-116Antitumor agent-116
Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis. It demonstrates binding affinity for the MELK receptor [1].
价 格:¥电议型 号:T79582产 地:中国大陆
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T79580Antitumor agent-115;化合物 Antitumor agent-115Antitumor agent-115
Antitumor agent-115 (SS-12) is a potent anti-tumor compound, exhibiting an IC50 range of 0.34 μM-24.14 μM against the 4T1 mouse breast cancer cell line. It impedes the cell cycle, diminishes mitochondrial membrane potential, and triggers apoptosis in these cells, with an IC50 for cell viability spanning 8-25 μmol/L. This compound is applicable in breast cancer research [1].
价 格:¥电议型 号:T79580产 地:中国大陆
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T79508Microtubule stabilizing agent-1;化合物 Microtubule stabilizing agent-1Microtubule stabilizing agent-1
Compound 3l, a paclitaxel derivative known as Microtubule Stabilizing Agent-1, effectively enhances tubulin polymerization and demonstrates antitumor efficacy [1].
价 格:¥电议型 号:T79508产 地:中国大陆
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T79466Antitumor agent-111;化合物 Antitumor agent-111Antitumor agent-111
Antitumor Agent-111 (Compound 46), a c-Met kinase inhibitor (IC50 = 46 nM), exhibits both antitumor and antiproliferative effects. It impedes the cell cycle at the G0/G1 phase and induces apoptosis [1].
价 格:¥电议型 号:T79466产 地:中国大陆
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T79463Antitumor agent-110;化合物 Antitumor agent-110Antitumor agent-110
Antitumor Agent-110 (Compound 13), an imidazotetrazine anticancer agent, exhibits excellent permeability. It halts the cell cycle at the G2/M phase and induces apoptosis [1].
价 格:¥电议型 号:T79463产 地:中国大陆
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T79449Antileishmanial agent-19;化合物 Antileishmanial agent-19Antileishmanial agent-19
Compound F27 (Antileishmanial agent-19) is an antileishmanial compound effective against L. donovani promastigotes, demonstrating an IC50 of 3.39 μM. It functions by inhibiting the Leishmania prolyl-tRNA synthetase and disrupting the host PI3K/Akt/CREB axis-mediated IL-10 secretion. Additionally, Compound F27 promotes autophagy-mediated apoptosis in L. donovani promastigotes and has been shown to reduce parasite burden in L.d-infected animals [1].
价 格:¥电议型 号:T79449产 地:中国大陆
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T79434Antitumor agent-103;化合物 Antitumor agent-103Antitumor agent-103
Antitumor Agent-103 (compound 24l) induces apoptosis and possesses antiproliferative and anti-colony formation properties. This compound halts the cell cycle at the G0/G1 phase, augments nitric oxide (NO) production, and demonstrates anti-tumor efficacy [1].
价 格:¥电议型 号:T79434产 地:中国大陆
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T79415Antiparasitic agent-18;化合物 Antiparasitic agent-18Antiparasitic agent-18
Antiparasitic agent-18 (compound 3a) exhibits potent and selective antiprotozoal activity, demonstrating effective inhibition of T. brucei (EC 50 =0.4 ?M), T. cruzi (EC 50 =0.21 ?M), and L. donovani (EC 50 =0.26 ?M) [1].
价 格:¥电议型 号:T79415产 地:中国大陆
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T79331Antioxidant agent-13;化合物 Antioxidant agent-13Antioxidant agent-13
Compound 5f (Antioxidant agent-13) is an antioxidant that demonstrates inhibition of DPPH and FRAP with half maximal inhibitory concentrations (IC50s) of 80.33 ?M and 85.69 ?M, respectively. Additionally, it inhibits the enzymes lipoxygenase (LOX) and xanthine oxidase (XO) with IC50s of 16.85 ?M and 23.01 ?M, respectively [1].
价 格:¥电议型 号:T79331产 地:中国大陆
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T79320Antitumor agent-114;化合物 Antitumor agent-114Antitumor agent-114
Antitumor Agent-114, a potent STING (stimulator of interferon genes) agonist, activates immune responses and diminishes tumor size in mouse breast cancer models, demonstrating potential applications in immunity and cancer research [1].
价 格:¥电议型 号:T79320产 地:中国大陆
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T79265Antitumor agent-104;化合物 Antitumor agent-104Antitumor agent-104
Antitumor Agent-104 (Compound 9) serves as an antineoplastic by impeding DNA repair mechanisms in tumor cells, primarily through the inhibition of PARP1 enzyme activity and reduction of PAR protein levels. Additionally, it suppresses CDK12 expression [1].
价 格:¥电议型 号:T79265产 地:中国大陆
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T79263Antitumor agent-102;化合物 Antitumor agent-102Antitumor agent-102
Antitumor Agent-102 (Compound 10), a conjugate integrating a Topoisomerase I inhibitor SN38 with a glucose transporter inhibitor, specifically targets colorectal cancer. This agent facilitates elevated levels of free SN38 in tumor tissues compared to Irinotecan [1].
价 格:¥电议型 号:T79263产 地:中国大陆
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T79249Antitumor agent-101;化合物 Antitumor agent-101Antitumor agent-101
Antitumor agent-101 is a selective, covalent inhibitor targeting lysine methyltransferases G9a/GLP, demonstrating IC50 values of 8.5 nM for G9a and 5.5 nM for GLP. It exhibits antitumor efficacy in the PANC-1 xenograft model [1].
价 格:¥电议型 号:T79249产 地:中国大陆
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T79138Antitumor agent-100 hydrochloride;化合物 Antitumor agent-100 hydrochlorideAntitumor agent-100 hydrochlo
Antitumor agent-100 hydrochloride (compound A6), serving as both an apoptosis inducer and molecular glue, exhibits superior anti-tumor activity [1].
价 格:¥电议型 号:T79138产 地:中国大陆
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T78966Antiparasitic agent-17;化合物 Antiparasitic agent-17Antiparasitic agent-17
Antiparasitic Agent-17 (compound 5u), an orally active antiparasitic, demonstrates inhibition against both Chloroquine-sensitive (Pf3D7) and Chloroquine-resistant (PfK1) strains, with IC50 values of 0.96 μM and 1.67 μM, respectively [1].
价 格:¥电议型 号:T78966产 地:中国大陆
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T78964Antileishmanial agent-17;化合物 Antileishmanial agent-17Antileishmanial agent-17
Antileishmanial agent-17, a coumarin hybrid, exhibits potent antileishmanial activity (IC50 <0.78 μM) while proving non-toxic to normal VERO cells. It specifically interacts with the folate pathway enzymes pteridine reductase and DHFR-TS. Efficacy against the promastigote form is highlighted by an IC50 value of 0.40 μM, and against the amastigote form, an IC50 of 0.68 μM, respectively.
价 格:¥电议型 号:T78964产 地:中国大陆
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T78963Antileishmanial agent-16;化合物 Antileishmanial agent-16Antileishmanial agent-16
Antileishmanial agent-16 (compound 14c), an anti-Leishmania agent, exhibits potent activity against Leishmania major promastigotes (IC50 = 0.59 ?M) and amastigotes (IC50 = 0.81 ?M), while maintaining a favorable safety profile in mammalian cells (VERO cells) [1].
价 格:¥电议型 号:T78963产 地:中国大陆
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T78962Antileishmanial agent-15;化合物 Antileishmanial agent-15Antileishmanial agent-15
Antileishmanial agent-15 (compound 13c) exhibits potent activity against L. major promastigotes and amastigotes, demonstrating IC50 values of 0.78 μM for promastigotes and 0.99 μM for amastigotes, while also showing cytotoxicity at these concentrations [1].
价 格:¥电议型 号:T78962产 地:中国大陆
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T78912Antitumor agent-113;化合物 Antitumor agent-113Antitumor agent-113
Antitumor Agent-113 exhibits cytotoxicity in A549 cells, with an IC50 of 46.60 μM, and induces apoptosis, making it applicable for research in non-small cell lung cancer [1].
价 格:¥电议型 号:T78912产 地:中国大陆